The document discusses the pathogenesis of bacterial infection, including the steps involved from initial exposure and penetration of the pathogen, multiplication and spread within the host, evasion of host defenses, and damage caused to the host tissues. Key aspects covered are virulence factors that enable bacterial survival and disease progression, different mechanisms of tissue injury caused by exotoxins and endotoxins, and the immune response damage.

1. PATHOGENESIS OF BACTERIAL INFECTION Dr Kamran Afzal Asst Prof Microbiology

8. Duration of Infectious Disease Few days (common cold) Weeks (hepatitis A) Months (rabies) Clearing (Strep throat, Strep pyogenes ) Latency (Chicken pox, tuberculosis) Transmission: Infectious dose from 10-10 6 organisms Weeks to months Months to years

11. Virulence Factors

34. Exotoxins vs. Endotoxins

36. Molecular Determinants of Pathogenicity Production and delivery of various factors Attachment to host tissues Replication and evasion of immunity Damage to host tissues