The document summarizes the pinacol-pinacolone rearrangement reaction, which converts an alcohol with two adjacent hydroxyl groups (a pinacol) into a ketone (a pinacolone) using an acid. It involves the following steps:
1) Protonation of one of the hydroxyl groups.
2) Loss of a water molecule.
3) Migration of an alkyl group to the carbocation formed.
4) Deprotonation to form the pinacolone product.
The reaction favors migration of groups that stabilize the carbocation intermediate best through resonance or inductive effects. For asymmetrical glycols, the group on the opposite side of
Pinacol pinacolone rearrangement involves conversion of 1,2 - diols to carbonyl compounds in presence of acid catalyst with change in carbon skeleton. It is an example of whitmore shift.
Pinacol pinacolone rearrangement involves conversion of 1,2 - diols to carbonyl compounds in presence of acid catalyst with change in carbon skeleton. It is an example of whitmore shift.
The presentation is prepared for lecture for the M. Sc Chemistry students studying under University of Madras (MER3A: Unit III). It is dealing with Aromaticity and Organic Photochemistry
Name: - Thall ium(I I I ) Nit rate t rihydrate
• Abbreviat ion: - TTN
• Melt ing point : - 102-105 °C.
• Solubi lity: - water, organic solvents.
• General informat ion:-
o Oxidizing agent ; Lewis acid.
o All thall ium compounds are ext remely toxic to
inhalat ion, skin contact , and ingest ion. Toxicity is
cumulat ive. Ext reme caut ion should be used when
handling these materials. Use in a fume hood.
Thallium nitrate is a select ive and versat i le oxidizing agent ,
general ly accompanied by reduct ion of Tl(I I I ) to Tl(I ). Thallium
nitrate is elect rophil ic in character, so it reacts wi th alkenes &
alkynes to give addit ion products.
I t is very ef fect ive oxidizing agent because: -
(i ) Reduct ion potent ial of this half cell react ion is posit ive and
high.
(i i) Carbon-TI(I I I ) bond is very weak, so it undergo heterolyt ic
cleavage very readily and form carbocat ion easi ly.
(i ii ) Nit rate-ion is not a very good nucleophile, so the solvent
may part icipate select ively as nucleophile in the react ion.
The Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually a aldehyde, ketone, or carboxylic acid, under acidic conditions to give an amine or amide, with expulsion of nitrogen
Molecular Rearrangements of Organic Reactions ppsOMPRAKASH1973
This PPT is usefull for aspirants of JEE-IIT, CSIR-NET and UPSC exams in CHEMISTRY section. It is also usefull for grduates and Post graduates students of Indian Universities.
The presentation is prepared for lecture for the M. Sc Chemistry students studying under University of Madras (MER3A: Unit III). It is dealing with Aromaticity and Organic Photochemistry
Name: - Thall ium(I I I ) Nit rate t rihydrate
• Abbreviat ion: - TTN
• Melt ing point : - 102-105 °C.
• Solubi lity: - water, organic solvents.
• General informat ion:-
o Oxidizing agent ; Lewis acid.
o All thall ium compounds are ext remely toxic to
inhalat ion, skin contact , and ingest ion. Toxicity is
cumulat ive. Ext reme caut ion should be used when
handling these materials. Use in a fume hood.
Thallium nitrate is a select ive and versat i le oxidizing agent ,
general ly accompanied by reduct ion of Tl(I I I ) to Tl(I ). Thallium
nitrate is elect rophil ic in character, so it reacts wi th alkenes &
alkynes to give addit ion products.
I t is very ef fect ive oxidizing agent because: -
(i ) Reduct ion potent ial of this half cell react ion is posit ive and
high.
(i i) Carbon-TI(I I I ) bond is very weak, so it undergo heterolyt ic
cleavage very readily and form carbocat ion easi ly.
(i ii ) Nit rate-ion is not a very good nucleophile, so the solvent
may part icipate select ively as nucleophile in the react ion.
The Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually a aldehyde, ketone, or carboxylic acid, under acidic conditions to give an amine or amide, with expulsion of nitrogen
Molecular Rearrangements of Organic Reactions ppsOMPRAKASH1973
This PPT is usefull for aspirants of JEE-IIT, CSIR-NET and UPSC exams in CHEMISTRY section. It is also usefull for grduates and Post graduates students of Indian Universities.
Favorskii rearrangement is one the important reactions in organic chemistry. Let us have some prior understanding of its mechanism and its applications.
Quick introduction on how to use Datascript with Reagent to build web applications.
Given to the Cambridge NonDysFunctional Programmers Meetup on November 13th 2014.
Use of stoichiometric amounts of a chiral source. The usual suspects will be discussed, including borane reagents (mostly pinene derivatives) and the Brown allylation.
A tale of scale & speed: How the US Navy is enabling software delivery from l...sonjaschweigert1
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
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Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
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The Metaverse and AI: how can decision-makers harness the Metaverse for their...Jen Stirrup
The Metaverse is popularized in science fiction, and now it is becoming closer to being a part of our daily lives through the use of social media and shopping companies. How can businesses survive in a world where Artificial Intelligence is becoming the present as well as the future of technology, and how does the Metaverse fit into business strategy when futurist ideas are developing into reality at accelerated rates? How do we do this when our data isn't up to scratch? How can we move towards success with our data so we are set up for the Metaverse when it arrives?
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Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
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💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Welcome to the first live UiPath Community Day Dubai! Join us for this unique occasion to meet our local and global UiPath Community and leaders. You will get a full view of the MEA region's automation landscape and the AI Powered automation technology capabilities of UiPath. Also, hosted by our local partners Marc Ellis, you will enjoy a half-day packed with industry insights and automation peers networking.
📕 Curious on our agenda? Wait no more!
10:00 Welcome note - UiPath Community in Dubai
Lovely Sinha, UiPath Community Chapter Leader, UiPath MVPx3, Hyper-automation Consultant, First Abu Dhabi Bank
10:20 A UiPath cross-region MEA overview
Ashraf El Zarka, VP and Managing Director MEA, UiPath
10:35: Customer Success Journey
Deepthi Deepak, Head of Intelligent Automation CoE, First Abu Dhabi Bank
11:15 The UiPath approach to GenAI with our three principles: improve accuracy, supercharge productivity, and automate more
Boris Krumrey, Global VP, Automation Innovation, UiPath
12:15 To discover how Marc Ellis leverages tech-driven solutions in recruitment and managed services.
Brendan Lingam, Director of Sales and Business Development, Marc Ellis
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
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Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
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This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
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The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
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Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
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After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
3. Mechanism
♦ Mechanism of the pinacol rearrangement of a
symmetrical glycol
CH3 CH3 CH3 CH3 _ OH CH3 CH
H2SO4 2 3
H3C CH3 H3C CH3 H3C +
OH OH OH OH2 OH CH3
+
1. Protonation of 2. Loss of water
pinacol a hydroxyl group
3. Methyl migration
4. Deprotonation
H3C CH3 H3C CH3 H3C CH3
+ CH3
CH3 _ + CH3 ..
O H H O+ H O
CH3 CH3 CH3
pinacolone Resonance-stablized carbocation
4. Facts
♦ 1, 2 shift takes place in carbonium ion
which is already a tertiary carbonium ion
♦ It is probably due to stabilization of
rearranged ion that can be affected by
delocalization involving the electron pair on
the oxygen atom, and ready loss of proton
from the oxygen to produce a stable end
product
5. The stable cation formed superior for
stabilization
Ph2C CH2 H+ Ph C CH2
+
2+ Ph2CH CH
OH OH OH
OH
Ph2CH CH +Ph2CH CH
+OH H
O
8. Facts
♦ It seems that migration of alkyl group is
extremely fast on the loss of leaving group,
taking place simultaneously
♦ That migrating group is from the opposite
side of the leaving group
– Because rearrangement is much more easy in
compounds having trans configuration than that
having cis configuration
9. Pinacol rearrangement of an asymmetrical
glycol
Me Ph Me
Ph O Me
H2SO4
HO OH HO + Ph
Me Ph Me Ph Me Ph
A B C
Me Ph
+ OH
Me Ph
D
Et Ph Et Ph O Et
H2SO4
HO OH HO + _ + Ph
Ph H
Et Ph Et Et Ph
E F
10. Which group migrates?
H+ PhHC CHPh
PhHC CHPh
+
OH OH OH
+
Ph2CH CH Ph2CH CH + Ph2CH CH
+OH H
OH O
Phenyl group move first because of
greater chances of stabilization due to
delocalization
12. ♦ The steric chemistry of Pinacol
Rearrangements
It is found that o-MeOPh migrate
more than a 1000 time less readily
that p-substituent and even much
less than phenyl. This is due to
interference in the transition state
with non-migrating group
13. Solved problem
Explain the following experimental facts :
R R R
R
R
C R +
H2SO4 O O
OH OH
(A) (B) (C)
When R=CH3, ( B ) and ( C ) are formed ;
When R=Ph, only ( C ) is formed.
14. When R=Me R R
+ C R
C R
+O H 2 OH OH
(1) (2)
R R
+ +
-H C R
R C R
+H+ :O H O
C R (3) (B)
OH OH
R R
(A)
+
C R C R
+ OH2
OH
(4) OH (5)
R + R
-H
+ R R
:O H
(6) O (C)