The document summarizes the Lossen rearrangement reaction. It begins with a brief history of the reaction's discovery in 1872 by W. Lossen. It then provides a general introduction and outlines the reaction mechanism. Specifically, it describes how a beta-hydroxamic acid is converted to an isocyanate intermediate via formation of an O-acyl derivative, which spontaneously rearranges to form the isocyanate. The isocyanate can then react with water to form an amine and carbon dioxide. Finally, it lists four references for additional information.