This document provides an outline for a lecture on the genetic basis of evolution. It begins with introducing key terms like gene, locus, allele, genotype, and phenotype. It then discusses genetic drift and how drift is influenced by population size. Selection is also introduced and defined as a process where individuals with different genotypes have different fitnesses. The document emphasizes that both genetic drift and selection influence evolution, and neither process should be overemphasized. It aims to move people away from only considering selection (pan-selectionism) and highlights the importance of genetic drift.
its deals with the general basic ideas of gene and evolutions.different types of examples are used to explain the gene and evolutions.the origin of basic genetics and their ideas are also formulated in this presentation
It states that the present day complex plants and animals have evolved from earlier simpler forms of life by gradual changes. SEQUENTIAL EVOLUTION ,DIVERGENT EVOLUTION, Theories of evolution.
Hi all! I used different references for this. The link for pros and cons is here.
Reference for pros and cons : https://vittana.org/11-biotechnology-pros-and-cons
its deals with the general basic ideas of gene and evolutions.different types of examples are used to explain the gene and evolutions.the origin of basic genetics and their ideas are also formulated in this presentation
It states that the present day complex plants and animals have evolved from earlier simpler forms of life by gradual changes. SEQUENTIAL EVOLUTION ,DIVERGENT EVOLUTION, Theories of evolution.
Hi all! I used different references for this. The link for pros and cons is here.
Reference for pros and cons : https://vittana.org/11-biotechnology-pros-and-cons
This presentation covers the basic terminology and key parameters of Population Genetics. Presentation is helpful for the students of Life Sciences and Evolutionary biology.
Evolution on how Charles Darwin the father of evolution explained the different types of mechanisms of evolution these are by natural selection, genetic drift, gene flow and many more
This is PPT on Evolution. This is just and introductory PPT. Soon There will be a PPT with much more on Evolution. Hope That you all like it. please like and share. each like Counts.
Epigenetics, Pedigree Analysis, Twins studies, Genetic Counseling, Prenatal testing, Linked genes, Chemical Nature of the Gene, History of Genetics, DNA Structure, RNA Structure and DNA Analysis.
During DNA replication, the two parental strands separate and each acts as a template to direct the enzyme catalysed synthesis of a new com-plementary daughter strand following the base pairing rule. Three basic steps involved in DNA repli-cation are Initiation, elongation and termination.
Keynote talk given at Fairdom User meeting http://fair-dom.org/communities/users/barcelona-2016-first-user-meeting/ .
I begin by summarising how we apply molecular approaches to understand social behaviour in ants. Subsequently, I give an overview of the data-handling challenges the genomic bioinformatics community faces. Finally, I give an overview of some of the tools and approaches my lab have developed to help us get things done better, faster, more reliably and more reproducibly.
2015 12-18- Avoid having to retract your genomics analysis - Popgroup Reprodu...Yannick Wurm
Brief (15min) talk I gave at #PopGroup49 in Edinburgh providing a few simple methods to reduce risk in genomics analyses.
Please cite: Avoid having to retract your genomics analysis (2015) Y Wurm. The Winnower 2, e143696.68941 https://thewinnower.com/papers/avoid-having-to-retract-your-genomics-analysis
Introduction to oSwitch - a docker-based manner of easily switching between host operating systems. Ideal for biologists who want to improve reproducibility and avoid pulling their hair out overcoming dependency issues.
This talk was given at the BioInDocker symposium organised at the Wellcome Collection in London on 10th & 11th November 2015 by Stephen Newhouse and Amos Folarin.
See also
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
4. Away from pan-selectionism
• Most people don’t really
understand evolution
• A very common mistake is
to take a pan-selectionist
view.“Everything can be
explained by selection.”
• This is an oversimplified
‘storybook’ view of evolution
5. Away from pan-selectionism
“Then the elephant sat back on his little haunches, and pulled,
and pulled, and pulled, and his nose began to stretch”
Pan-selectionist would
try to come up with a
story for why the trunk
confers a selective
advantage
!
This is not much better
than a ‘just so’ story
7. Away from pan-selectionism
• First and foremost is genetic drift which goes on in all
populations and accounts for much of the genetic
differentiation between individuals, between populations of the
same species and between different species.
• Second we must understand the action of the basic modes of
selection. It’s not a case of choosing between selection or
drift; selection occurs against a background of drift.
DRIFTSELECTION
9. Defining ourTerms, Part I
We need to understand the following vocabulary, so that we
can use the words accurately and confidently:
1. Gene
2. Locus
3. Allele
4. Genotype
5. Phenotype
Write down your best definition of
each of these terms
10. Definition: Gene
Gene
• Segregating and heritable determinant of the phenotype.
• The fundamental physical and functional unit of heredity, which
carries information from one generation to the next.
• A segment of DNA, composed of a transcribed region and
regulatory sequences that make possible transcription.
• Human Genome Nomenclature Organization:“a DNA
segment that contributes to phenotype/function”
• Long distance regulation? Alternative splicing?
Our definition of the gene is getting
fuzzier all the time
11. Definition: Locus
Locus (pl. loci)
• The position on a chromosome of a gene or other chromosome
marker
• Can also refer to the DNA at that position
• The use of locus is sometimes restricted to mean regions of DNA
that are expressed
[Source: DOE Primer on Molecular Genetics]
12. Definition: Locus
We can find specific DNA sequences in the genome by going
FISHing. (FISH = flourescence in situ hybridisation)
N-myc locus on 2p24 (normally)
13. Definition: Locus
Multiple copies of n-myc rearranged in a homogeneously
staining region (HSR) on a different chromosome - one of the
classic ways in which n-myc amplicons are formed.
14. Definition:Allele
Allele
• Variant of a gene. Different alleles can lead to different
phenotypes
• Diploids have two copies of each gene.
A homozygote possesses two copies of the same allele, while a
heterozygote possesses two different alleles
Allele Frequency (proportion)
Frequency of A allele:
p = 11/16 = 0.6875
(i.e. 2×Homozygotes + Heterozygotes)
15. Definition: Genotype
Genotype
• The genetic makeup of an individual
• A description of the alleles possessed by an individual
Genotype frequency
Under random mating we expect to see
Hardy-Weinberg genotype frequencies:
p2 2p(1-p) (1-p)2
0.5 0.375 0.125
16. Definition: Genotype
When alleles are rare they are more commonly found in
heterozygote genotypes
Remember this graph – it will come in very handy when
we come to think about drift and selection later on!
17. Definition: Phenotype
Phenotype
• The physical characteristics of an individual
• Composed of ‘traits’
• Interaction of genes and environment. Genetic component of the
phenotype is heritable, environmentally acquired component of
phenotype is not.
• What about the ‘extended’
phenotype?
• Does this cased Caddisfly’s
shell constitute a phenotype?
18. Defining ourTerms, Part II
We need to understand the following vocabulary, so that we
can use the words accurately and confidently:
6. Gamete
7. Zygote
8. Dominant
9. Recessive
Write down your best definition of
each of these terms
19. Definition: Gamete & Zygote
Gamete
• Germline cell that is able to unite with another of the opposite sex
during sexual reproduction
• Produced by meiosis
• Contains half the chromosomes of the parents
Zygote
• The earliest developmental stage
of the embryo
• Produced by the fusion of
two gametes
20. Definition: Dominant & Recessive
Which of these statements areTrue and which are False…
• The terms ‘dominant’ and ‘recessive’ apply to genes
• The terms ‘dominant’ and ‘recessive’ apply to alleles
• The dominant allele is the one that is selected for
• If the alleles are A and a then A is the dominant allele
• The dominant allele is the most common in the
population
• The dominant allele expresses its phenotype even when
present in a heterozygote
• If A is dominant over a then individuals who are AA and
Aa have the same phenotype (but…)
(Convention,
not a rule)
21. Bringing it all together
• Two alleles of the same gene, called
A and a.
• A homozygous AA individual mates
with a heterozygote.We can list the
gametes that can be produced by
each parent.
• These gametes fuse to form zygotes,
and hence offspring individuals of
the next generation.
22. Bringing it all together
• What genotype proportions would we
expect to see in the zygotes?
• We know that A is dominant over a, and
codes for red feathers.What proportion
of individuals in the offspring generation
would we expect to have red feathers?
• There are two processes that could
cause an offspring not to have red
feathers – one that I’ve mentioned and
what that I haven’t yet.What are they?
Environment
Mutation
25. Genetic Drift
• Genetic drift describes the process by which allele frequencies
change over time due to the effects of random sampling.
• Drift takes place as a consequence of finite population size.
• It is not a case of choosing between selection or drift. Genetic
drift takes place in all populations, and any selection must
occur against this background of drift.
• Genetic drift can help us to understand differences between
individuals, between populations of the same species and
between different species.
26. Genetic Drift
How does it work?...
• Imagine a finite population of individuals.
Let us assume that every individual in the
population is as fit as every other.
Assume complete random mating.
• Take a particular individual of the
offspring generation. It is equally likely
that any member of the previous
generation is the parent.
• We can go even further – any gene copy
in the offspring generation has an equal
chance of coming from any gene copy in
the parental generation.
27. Genetic Drift
We can simplify the process…
• Just focus on the gametes of each
generation.
• We can say that the next generation of
gametes is produced by sampling with
replacement from the previous generation.
• By pure chance we might sample a
particular allele more or less often than
expected, causing the allele frequencies to
change from one generation to the next.
• This occurs generation after generation,
causing allele frequencies to drift over time.
28. Genetic Drift: Example
Two alleles called A and a. Starting allele frequency of A is p=0.6,
meaning the starting allele frequency of a must be (1-p)=0.4
Generate next generation by sampling with replacement from
previous generation
!
Same process again. Notice that the allele frequency drifted from
one generation to the next.
29.
30. Simulation starting with 100
heterozygous individuals
(p=0.5)
Genetic Drift
Graph of a particular allele frequency as it changes over time
Notice that eventually the allele frequency gets stuck at p=1.
• It gets stuck here because there is only one allele left to sample!
• This is called fixation.The allele has become fixed in the population.
• The other possibility is that the allele gets lost, in which case the other
allele must have become fixed (assuming two alleles)
(population size
= 100 diploids)
31. Genetic Drift
Look at many replicates of the process of evolution
• Equal chance of drifting up or down
• If we leave enough time we can be certain that one or other
allele will become fixed, and the other will become lost.
• Which of these events is more likely depends only on the
starting allele frequency. There is no selection in this model!
32. Think about it….
!
Would genetic drift be stronger in a
smaller population or a larger
population?
33. Genetic Drift
Genetic drift is stronger in a small population than in a large
population
The effect of random sampling is greater in a small
population than in a large population
34. Genetic Drift
One place that drift can be particularly strong is when a
population undergoes a bottleneck
The human population has almost certainly gone through
several such bottlenecks on way out of Africa
35. Genetic Drift
At the moment our model of how a population evolves is an
extremely simplified cartoon of real life.We could make it more
realistic by…
These modifications make very little difference to the process of
drift!The key fact is always true:
• Allowing for two separate sexes
• Allowing the population size to change over time
• Using a more realistic model for how many offspring
an individual might have
• Etc.
37. Defining Fitness
We know that selection occurs because different individuals
have different fitness, but what exactly do we mean by this
word fitness?
Write down an evolutionary definition of the word fitness.
Consider the following questions…
1) What is fitness?
2) Is fitness a property of alleles, genes,
genotypes or phenotypes?
!
38. Defining Fitness
The word fitness in an evolutionary context can be defined
as…
“The expectation of the number of descendant lineages at the
same stage of the life cycle in the next generation.”
Low
fitness?
High
fitness?
I will use ‘fitness’ to mean a property of genotypes - not alleles
or even phenotypes.
39. Example: a population of 4 individuals mate and produce offspring
The absolute fitness is the number of
lineages (i.e. successful gametes) from
individuals from a specific genotype,
divided by the number of individuals from
the parental generation.
Calculating/Estimating Fitness
Absolute fitness AA = 10/2 = 5
Absolute fitness aa = 4/2 = 2
Fitness has many components – for
example AA and aa differ here in both
viability and reproductive success
40. Absolute and Relative Fitness
Relative fitness is calculated by dividing all
fitness values by the largest value (thus the
fittest genotype always has a relative fitness=1).
Relative fitness AA = 5/5 = 1
Relative fitness aa = 2/5 = 0.4
Notice that aa actually left as many descendent
genes as it had in the first generation, and yet its
relative fitness is still less than 1
Absolute fitness :
Absolute fitness AA = 10/2 = 5
Absolute fitness aa = 4/2 = 2
Example: a population of 4 individuals mate and produce offspring
41. Fitness and selection
Fitness is a property of a particular genotype. Selection is a process
(not really a ‘force’) leading to different expectations of transmitting
genes to the next generation.
• If different individuals of a population have different fitness then
we say that selection is operating.
• If they have the same fitness then we say that there is no
selection, or equivalently, that the population is evolving neutrally.
What kind of evolution might we expect to see if there was no
selection operating?...
Genetic Drift!
42. Fitness and selection
The fitness of different genotypes is often represented by the
symbol ω (omega).
• For example, the fitness of the AB genotype is often
represented by the symbol ω AB
The strength of selection is often represented by the symbol s.
• For example, if AB is not the fittest genotype then the strength
of selection against heterozygotes can be thought of as the
deficit from a relative fitness of 1, so that
ω AB = 1 – s
43. Selection and Drift Combined
• Previously we imagined that all individuals
had the same fitness
• Taking a particular individual of the offspring
generation, it was equally likely that any
member of the previous generation was the
parent.
• The effect of high fitness is to make an
individual more likely to be the parent of
offspring in the next generation
• It is still possible that a fit individual will get
unlucky and end up having no kids
44. Genetic Drift
Look at many replicates of the process of evolution
• Equal chance of drifting up or down
• If we leave enough time we can be certain that one or other
allele will become fixed, and the other will become lost.
• Which of these events is more likely depends only on the
starting allele frequency. There is no selection in this model!
No Selection
Happening
45. Selection and Drift Combined
A model in which A is dominant and has high fitness.Allele frequencies
still drift around as before, but now there is a systematic change in an
upward direction.
Notice that there is still one case in which, despite the high fitness of
individuals with the A allele, the A allele gets lost due to pure chance.
47. Away from pan-selectionism
• Genetic drift is one of the most important
processes in evolution.
• It is not a case of choosing between selection or
drift. Selection occurs against a background of
drift.
DRIFTSELECTION
48. Announcements
• There will be a workshop in week 8 on drift.The assessment
completed during the workshop will count for 20% of your
score in this course.
• In this workshop we will use the program PopG. When
you arrive, you will be tested on your ability to use PopG.
Full details of how to access the program and what you
will be tested on will be on the course website.
• Make sure you have submitted 1 question per week of
course material on Peerwise.