This document defines and describes transmission-based precautions, including contact, droplet, and airborne precautions. Contact precautions are used for pathogens spread by direct or indirect contact and aim to contain them. Droplet precautions are for diseases transmitted through respiratory droplets within 3-6 feet and include masking healthcare workers. Airborne precautions, the most stringent, are for pathogens that transmit through airborne particles like tuberculosis, and involve airborne isolation rooms, respirators, and waiting at least an hour before cleaning.