about tablet equipment

1. MD.MOHSIN

3. Rapid Mixer Granulator (RMG)
The Rapid Mixer Granulator is a
multi-purpose processor equally
suitable for high speed dispersion
of dry powders, aqueous or
solvent granulations and mixing
purposes.
Working principle:
Mixing and Wet Granulation
Process is performed in one
sequence.
The fast moving mixer blades
enforce the powder material in to

4. Working principle contd.
This vortex effect in the material provides faster and
uniform (even) distribution of the ingredients.
This intensive mixing action distributes "active"
substances homogeneously within few minutes
By adding binder through charging hole at the top cover,
particles are uniformly moistened and aggregated to
large granules.
The vertically rotating, specially designed chopper
blades shears the circulating powder and breaks down
lumps and aggregates.
Thus granules attain higher density and uniformity in
shape, thereby achieving a uniform particle size
distribution.

6. Why used?
Excellent mixing and
consistent granules at lower
operating cost
Higher productivity.
Closed control of granule
size
Faster tableting speeds with
improved quality
Least rejections.

7. Fluidized bed dryer
The fluid bed principle is used to advantage in heating,
cooling, carrying out chemical reactions, homogenising,
and drying, but the success of these applications can
only be realised when the solid sample is thoroughly
mixed during the process.
Working principle:
 Wet granules are placed at the detachable bowl and is
pushed into the dryer
 Fresh air passed through the pre filter and the gas are
heated while passing through the heat exchanger
 Hot air flows through the bottom of the bowl
 Air velocity is gradually increased
 Granules rise from the container then fall back,this

8. Working principle contd.
 Gas will surround the
granules for complete
drying
 Air leaves the dryer by
passing through the bag
filter
 Periodically bags are
shaken to remove the
entrained particle
 Bowl is taken out for
discharging and the end
product is free flowing
 Residence time for drying:

10. Why used?
 Mostly used for drying of
granules
 3 major functions: drying,
granulation & mixing
 Also used for coating
purposes

11. Tablet Compression Machine
Compression is an important stage in tablet
manufacturing. There are mainly two ways to
compress tablet.
 1.single punch
 2.multiple punch/rotary press
Tablet Compression Machine is consist of
1. Hopper
2. Dies
3. Punches
4. Cam tracks
5. A feeding mechanism

12. Working principle

14. Why used?
 To get the final product.
 To get tablets in different
sizes and shapes.
Caplet Shape
Dies
Oval Shapes
Dies
Round Shapes Dies Star Shapes
Dies

15. Coating machine
 Tablet coating is the
application of coating
composition to moving
bed of tablets with
concurrent use of heated
air to facilitate
evaporation of solvent.
 Substances used for
coating are usually
applied as solution or
suspension under
conditions where vehicle

16.  Tablets are loaded into the machine at the beginning of
each batch.
 They tumble on a rotating drum while a coating liquid
(solution, dispersion, or melt) sprays through nozzles
onto their surface.
 Meanwhile, fans direct heated air through the tablets
and the perforated drum.
 This air either evaporates the solvent or cools the melt.
 The integrated plenum pans operate effectively at lower
airflows, which make them better suited for solvent
coating applications.
 This process continues until the tablets are sufficiently

18.  To mask unpleasant taste, odor
or color
 To protect products from
environment, e.g. light, moisture,
oxygen
 To reduce incompatibility
 -To control drug release
- enteric coating
- sustained release coating
 To promote aesthetic property
 Avoid irritation of stomach
 Reduce influence of moisture