Wet granulation is a process that uses a granulating liquid like ethanol or water to mix powder particles. It involves mixing powders and a binder solution, sieving the wet mixture, drying the granules, and sieving the dry granules. Common methods are shear granulation, fluid bed granulation, and spheronization which forms spheres or pellets. Wet granulation produces granules that compress well and result in tablets with consistent properties, though it uses more energy than dry granulation and powders must be stable with water.

1. Wet
Granulation:

2. Wet Granulation:
• Method in which the powder
particles mix can be done by
the use of granulating liquid.
• Volatile solvent is used as a
granulating liquid.
GRANULATING LIQUIDS:
• Ethanol.
• Isopropanol & water (used
individually or in the
combination).

3. Steps involve in Wet granulation
1. Mingling of Excipients &
Drugs.
2. Mixing of powder with
binder solution.
3. Granular sieving of wet
mixture.
4. Drying of soggy
granules.
5. Sifting of dry granules.

4. Methods involve in Wet granulation:
1) Shear Granulator:
dry powder mixing has to be
accomplished in a single
primary process using diverse
mixing equipment’s for
powders.
replaced by high speed
granulators.
2) Fluid bed granulation:
particles of powder are fluidized
in an air stream.
the granulating liquid is added
into the powder bed.

5. Methods involve in Wet granulation:
3) Spheronization (Extrusion):
yield multi particulates by the
application of measured release of
drug.
produces spheres or pellets loaded
with drug
4) High Speed granulator:
is used widely for medicinal
granulation.
established from old-style
environmental mixers to accelerate
the procedure
to decrease the quantity of
equipment’s.

6. Advantages of wet granulation:
 Production of granules
 Shows high compression of particles.
 Hardness, disintegration, dissolution, and
moisture, correlation in compacted
tablets is prepared by this Process
Disadvantages of wet granulation:
 High energy utilization
 Less stable with water