Description about Wet Granulation:

1. Wet
Granulation:

2. Wet Granulation:
• Method in which the powder
particles mix can be done by
the use of granulating liquid.
• Volatile solvent is used as a
granulating liquid.
GRANULATING LIQUIDS:
• Ethanol.
• Isopropanol & water (used
individually or in the
combination).

3. Steps involve in Wet granulation
1. Mingling of Excipients &
Drugs.
2. Mixing of powder with
binder solution.
3. Granular sieving of wet
mixture.
4. Drying of soggy
granules.
5. Sifting of dry granules.

4. Methods involve in Wet granulation:
1) Shear Granulator:
dry powder mixing has to be
accomplished in a single
primary process using diverse
mixing equipment’s for
powders.
replaced by high speed
granulators.
2) Fluid bed granulation:
particles of powder are fluidized
in an air stream.
the granulating liquid is added
into the powder bed.

5. Methods involve in Wet granulation:
3) Spheronization (Extrusion):
yield multi particulates by the
application of measured release of
drug.
produces spheres or pellets loaded
with drug
4) High Speed granulator:
is used widely for medicinal
granulation.
established from old-style
environmental mixers to accelerate
the procedure
to decrease the quantity of
equipment’s.

6. Advantages of wet granulation:
 Production of granules
 Shows high compression of particles.
 Hardness, disintegration, dissolution, and
moisture, correlation in compacted
tablets is prepared by this Process
Disadvantages of wet granulation:
 High energy utilization
 Less stable with water