- Methionine and cysteine are sulfur-containing amino acids. Methionine is an essential amino acid while cysteine can be synthesized from methionine and serine. - There are three major metabolic routes for methionine and cysteine: 1) methionine is used for transmethylation, 2) methionine is used for cysteine synthesis, and 3) cysteine is broken down to make specialized products. - Deficiencies in enzymes involved in methionine and cysteine metabolism can cause inborn errors such as homocystinuria, cystathioninuria, and cystinosis.