Alanine is a non-essentia, aliphatic amino acid. This presentation is made for MBBS, MD and BDS students.

1. Dr. V.P.Acharya, Professor,
Biochemistry

2. AliphaticAA
Non-essential
Glucogenic

3.  In presence of ALT from Pyruvate and
Glutamate
 Transamination

4.  Reversal of the same reaction
 No metabolic disorder

5.  Major glucogenicAA
 Role in regulation of blood glucose

6.  -NH2 gr. attached to β carbon atom
 Mammals- produced during catabolism of
Pyrimidine synthesis

7.  Substrate for Coenzyme-A
Pantothenic acid = Pantoic acid + β-alanine
 Carnosine- a dipeptide
Histidine + β-alanine
 Carnosine methylated→ Anserine → in birds

8. Buffer the pH of anaerobically contracting
skeletal mm.
Activate Myosin ATPase
Chelate Copper
↑copper uptake- Role inWilson’s disease

9.  Hyperbeta-alaninemia – rare congenital disorder
 Homocarnosinosis - Accumulation of
Homocarnosine - rare
Characterized by- Mental Retardation, spastic
paraplegia

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