Metabolism of glycine
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Biochemistry from Dr. Dhiraj J Trivedi SDM College of Medical Sciences and Hospital, Dharwad, India
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Metabolism of glycine
- 1. METABOLISM OF GLYCINE C COOHH2 N H H Dr. Dhiraj J. Trivedi
- 2. GLY CINE • Simplest, optically inactive , Non essential amino acid • Glycogenic amino acid , • Inhibitory Neurotransmitter. • Actively involved in synthesis of specialized products • Participate in one carbon metabolism • Excessive consumption leads to renal stone.
- 3. GLYCINE Serine Collagen Glyoxylate Ox a lic a c id Co2+NH4 Methylene THF Creatine Heme Glutathione Purine Detoxification Hippuric acid , Bile salt Glycogenic Threonine
- 4. SYNTHESIS OF GLYCINE 1. From Carbon dioxide and ammonia 2. From Glyoxylate 3. From Serine 4. From Threonine 5. From Choline
- 5. CO2 Methylene -THF THF Glycine synthetase Glycine NH3 Glycine from CO2 and NH3 NADH NAD + In Liver mitochondria PLP 1 1
- 6. Glycine from Glyoxylate Glyoxylate Glycine Alanine / Glutamate Pyruvic acid / α -KG Alanine Glyoxylate TransaminasePLP H O C COOH Keto acid H2O H2O2 Glycine Oxidase 2
- 7. Glycine from Serine Glycine Serine OH-methyl transferase Serine Methylene -THF THF PLP H2N CH2OH CH COOH Serine 3
- 8. Threonine aldolase Threonine Glycine from Threonine Glycine PLP C COO NH3 H C CH3 OH H C CH3 O H Acetaldehyde 4
- 9. OXIDATION OF GLYCINE 1. To CO2 and NH4 2. To Glyoxylate
- 10. CO2 Methylene -THF THF Glycine NH3 Glycine to CO2 and NH3 Glycine Cleavage complex Glycine cleavage complex , Present in Neonatal Liver Deficiency of which leads to hyper glycinemia Glycine is inhibitory NT , cause neurological disorder NADH NAD +
- 11. Glycine Imino acid FP FPH2 Glycine oxidase H2O2 O2 Glyoxylate H2O NH3 Oxalic acid ½ O2 oxidation If accumulate leads to kidney stone GLYCINE to Glyoxylate
- 12. Oxalic acid ½ O2 oxidation GlycinePyruvic acid Alanine Glyoxylate Transaminase Glyoxylate Alanine Primary Oxaluria type I Mental retardation Kidney stone TRANSAMINATION OF GLYCINE
- 13. Glyoxylate CO2 Decarboxylase Formate N5 N10 formyl THF Glycine to formate THF
- 14. Glycine Arginine+ Guanidinoacetate methyl transferase Creatine AD PATP Creatine- phosphate C PK In Kidney In Liver In Muscle Synthesis of Creatine Transamidase Ornithine SAM SAHC
- 15. Glutamate Cysteine γ-Glutamyl cysteine Glutathione ADP + Pi ATP Synthesis of Glutathione Glycine ADP + Pi ATP γ Glutamyl cystein synthetase + Glutamyl cystenyl glycine Glutathione synthetase 2 G SH G SSG N AD P NAD PH + H Glutathione r educ tas e
- 16. Glycine Succinyl COA+ δ Amino levulinic acid Porphobilinogen Heme Mitochondria 2 molecules δ-Amino levulinate synthaseCO-A + CO2 SYNTHESIS OF HEME δ Am ino levulinic acid
- 17. Synthesis of Hippuric acid and Bile salts Benzoic acid Benzoyl CO A Benzoyl glycine / Hippuric acid Cholic acid Cholyl CO A Glyco-cholic acid CO A SH ATP ADP + Pi
- 18. C6 C2 C8 C5 C4 N 3 N 1 N7 N 9 Aspartate GlycineCO2 Glutamine N-formyl H4F N-formyl H4F Glycine for Purine ring synthesis