Steps of Glycolysis in a brief
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Here i made a presentation on the topic GLYCOLYSIS. I Demonstrated the ten steps of Glycolysis in a few word and flow chart so that you can easily learn about it.
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Steps of Glycolysis in a brief
- 2. What is Glycolysis Glycolysis (from the Greek glykos, meaning sweet, and lysis, meaning splitting) involves the breakdown of glucose, a simple sugar. This process can occur in the presence or absence of oxygen, that is, under aerobic or anaerobic conditions.
- 3. History of Glycolysis During the 1930s, the efforts of several German biochemists, including Gustav Embden, Otto Meyerhof, and Jacob Parnas, determined that glycolysis involves 10 steps, each one catalyzed by a different enzyme.
- 5. Step 1 Glucose is phosphorylated by ATP. Glucose-6-phosphate is more easily trapped in the cell compared to glucose. ATP ADP Hexokinase Glucose Glucose-6-Phosphate
- 6. Step 2 The structure of glucose-6-phosphate is rearranged to fructose-6-phosphate. Phosphogluco isomerase Glucose-6-Phosphate Fructose-6-phosphate
- 7. Step 3 Fructose-6-phosphate is phosphorylated to make fructose-1,6-bisphosphate. ATP ADP Phosphofructo kinase Fructose-6-phosphate Fructose-1,6-bisphosphate
- 8. 4. Fructose-1,6-bisphosphate is cleaved into dihydroxyacetone phosphate and Dihydroxyacetone phosphate glyceraldehyde-3-phosphate. 5. Di-hydroxyl-acetone phosphate is somerized to glyceraldehyde-3-phosphate. 4. 5. Isomerase Aldolase Fructose-1,6-bisphosphate Glyceraldehyde-3phosphate (x2)
- 9. 6. Glyceraldehyde-3-phosphate is oxidized to 1,3bisphosphoglycerate. NADH is produced. In 1,3-bisphospho-glycerate,the phosphate group in the upper left is destabilized, meaning that the bond will break in a highly exergonic reaction. Unstable Phosphate Bond 2NADH 2 NAD+ Glyceraldehyde-3phosphate (x2) +2H+ Glyceraldehyde-3phosphate dehydrogenase 1,3-bisphosphoglycerate (x2)
- 10. 7. A phosphate is removed from 1,3-bis-phospho-glycerate to form 3-phosphor-glycerate. The removed phosphate is transferred to ADP to make ATP via substrate-level phosphorylation. Unstable Phosphate Bond 2ATP 2ADP Phosphoglycero– kinase 1,3-bisphosphoglycerate (x2) 3-phosphoglycerate(x2)
- 11. 8. The phosphate group in 3 phosphoglycerate is moved to a new location, creating 2phosphoglycerate Phosphoglycero– mutase 3-phosphoglycerate(x2) 2-phosphoglycerate(x2)
- 12. 9. A water molecule is removed from 2-phosphor-glycerate to form phosphor-enol-pyruvate. In phosphor-enol-pyruvate, the phosphate group is destabilized, meaning that the bond will break in a highly exergonic reaction. Unstable phosphate bond Enolase 2-phosphoglycerate(x2) Phosphoenolpyruvate(x2)
- 13. 10. A phosphate is removed from phosphor-enol-pyruvate to form pyruvate. The removed phosphate is transferred to ADP to make ATP via substrate-level phosphorylation. Unstable phosphate bond 2ADP 2ATP Pyruvate Kinase Phosphoenolpyruvate(x2) pyruvate(x2)
- 14. :p Thanks God! It’s over at last!!