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REACTIONS OF
CARBOHYDRATES
BY EKHLAQUE BIOTECH
ekhlaquebiotech@gmail.com
REACTION OF GLYCOSIDIC OH GROUP
Reaction with alcohol
The glycosidic OH group of mutarotating
sugars react with alcohols to form α- and β-
glycosides or acetals.
Thus, glucose forms glucosides and fructose
forms fructosides.
The glucosides, or glycosides in general, do
not exhibit mutarotation as the aldehyde group
in them is converted to the acetal group.
Phlorhizin (Glucose + Phloretin) in rose bark
Digitonin (4 Galactose + Xylose + Digitogenin) in foxglove leaves
Amygdalin (2Glucose + 2 Mandelonitril) from bitter almonds
Saponin (Sugar + Sapogenin) from soapwort.
They are useful as medicaments.
REACTION OF GLYCOSIDIC AND
ALCOHOLIC OH GROUPS
Reaction with acetic anhydride
(Esterification)
The glycosidic and alcoholic OH groups of
monosaccharides and disaccharides react with
acetylating agents to form acetate derivatives
called esters.
REACTION OF ALCOHOLIC
OH GROUP
Reaction with methyl iodide (Etherification)
•The alcoholic OH groups of monosaccharides and
disaccharides are converted to ether groups upon
treatment with methylating agents.
This reaction has been extensively used to ascertain
which OH groups in a sugar are free and available
for reaction.
α-methyl glucoside is methylated at carbon 2, 3, 4 and 6 but not at
carbon 5 which is involved in hemiacetal link.
REACTION OF BOTH ALCOHOLIC
OH AND CHO/CO GROUPS
Oxidation with acids
The alcoholic OH group and CHO group (or CO group) are oxidized to
carboxyl groups by certain oxidizing agents.
The oxidation may be brought about under mild or vigorous oxidizing
conditions.
With mild oxidants (like HOBr)
Only the aldehyde group is oxidized to produce monocarboxylic acids.
Ketoses, however, do not respond to this reaction. Hence, this reaction
is used to distinguish aldoses from ketoses.
With strong oxidants (like conc. HNO3)
Both the aldehyde group (or ketone group) and the primary alcohol are
oxidized to yield dicarboxylic acids.
With aldoses, acids with same number of carbon atoms are obtained
whereas ketoses react to produce acids with fewer number of carbon
atoms.
REACTIONS OF CHO/CO GROUP
Oxidation with metal hydroxides.
Cu(OH)2, AgOH and Bi (OH)3 oxidize the free aldehyde (or
ketone) group of mutarotating mono- and di-saccharides and
reduced to the lower oxides or to the free metals.
Cu(OH)2 is reduced to Cu2O and AgOH
Bi(OH)3 are reduced to the free metal, Ag and Bi
Reducing sugar + 2 Cu++ → Oxidized sugar + 2 Cu+
Reactions Of Carbohydrates
Reactions Of Carbohydrates

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Reactions Of Carbohydrates

  • 1. REACTIONS OF CARBOHYDRATES BY EKHLAQUE BIOTECH ekhlaquebiotech@gmail.com
  • 2. REACTION OF GLYCOSIDIC OH GROUP Reaction with alcohol The glycosidic OH group of mutarotating sugars react with alcohols to form α- and β- glycosides or acetals. Thus, glucose forms glucosides and fructose forms fructosides. The glucosides, or glycosides in general, do not exhibit mutarotation as the aldehyde group in them is converted to the acetal group.
  • 3. Phlorhizin (Glucose + Phloretin) in rose bark Digitonin (4 Galactose + Xylose + Digitogenin) in foxglove leaves Amygdalin (2Glucose + 2 Mandelonitril) from bitter almonds Saponin (Sugar + Sapogenin) from soapwort. They are useful as medicaments.
  • 4. REACTION OF GLYCOSIDIC AND ALCOHOLIC OH GROUPS Reaction with acetic anhydride (Esterification) The glycosidic and alcoholic OH groups of monosaccharides and disaccharides react with acetylating agents to form acetate derivatives called esters.
  • 5.
  • 6. REACTION OF ALCOHOLIC OH GROUP Reaction with methyl iodide (Etherification) •The alcoholic OH groups of monosaccharides and disaccharides are converted to ether groups upon treatment with methylating agents. This reaction has been extensively used to ascertain which OH groups in a sugar are free and available for reaction.
  • 7. α-methyl glucoside is methylated at carbon 2, 3, 4 and 6 but not at carbon 5 which is involved in hemiacetal link.
  • 8. REACTION OF BOTH ALCOHOLIC OH AND CHO/CO GROUPS Oxidation with acids The alcoholic OH group and CHO group (or CO group) are oxidized to carboxyl groups by certain oxidizing agents. The oxidation may be brought about under mild or vigorous oxidizing conditions. With mild oxidants (like HOBr) Only the aldehyde group is oxidized to produce monocarboxylic acids. Ketoses, however, do not respond to this reaction. Hence, this reaction is used to distinguish aldoses from ketoses.
  • 9. With strong oxidants (like conc. HNO3) Both the aldehyde group (or ketone group) and the primary alcohol are oxidized to yield dicarboxylic acids. With aldoses, acids with same number of carbon atoms are obtained whereas ketoses react to produce acids with fewer number of carbon atoms.
  • 10. REACTIONS OF CHO/CO GROUP Oxidation with metal hydroxides. Cu(OH)2, AgOH and Bi (OH)3 oxidize the free aldehyde (or ketone) group of mutarotating mono- and di-saccharides and reduced to the lower oxides or to the free metals. Cu(OH)2 is reduced to Cu2O and AgOH Bi(OH)3 are reduced to the free metal, Ag and Bi Reducing sugar + 2 Cu++ → Oxidized sugar + 2 Cu+