This document summarizes key aspects of the respiratory system and the effects of smoking. It describes the major parts of the respiratory system including the nose, larynx, trachea, lungs, bronchi, and alveoli. It explains how gas exchange occurs in the alveoli and the composition of inhaled and exhaled air. It also details the mucus elevator defense system and effects of smoking such as increased risk of various diseases, cancer, and overall shortened lifespan.