Respiration is regulated by both nervous and chemical mechanisms. The nervous mechanism involves respiratory centers in the medulla oblongata and pons that collect sensory information and control respiratory muscles. There are four respiratory centers - the inspiratory and expiratory centers in the medulla, and the pneumotaxic and apneustic centers in the pons. The chemical mechanism involves central and peripheral chemoreceptors that detect changes in blood oxygen, carbon dioxide, and hydrogen ion levels and stimulate the respiratory centers.
Regulation of respiration (the guyton and hall physiology)Maryam Fida
Normal respiration is spontaneous and unconscious.
There are 4 groups of neurons on each side in the Pons and medulla oblongata which are involved in regulation of respiration. These include
1. Medullary centers
Dorsal respiratory group of neurons
Ventral respiratory group of neurons
2. Pontine centers
Pneumotaxic centre
Apneustic centre.
It contains “I”neurons which are inspiratory neurons.
It’s located in dorsal portion of medulla oblongata.
It also includes the nucleus of tractus solitarius which is the sensory termination of afferent fibers in 9th ( GLOSSOPHARYNGEAL NERVE) and 10th (VAGUS NERVE) cranial nerves.
They receive impulses from peripheral chemoreceptors, carotid and aortic baroreceptors and also other receptors in the lungs.
In this group inspiratory ramp signals are produced spontaneously.
If we cut the medulla oblongata from other parts of brain and also the afferent nerves which enter the medulla, still inspiratory ramp signals are produced which indicate it’s the inherent property of medulla.
Initially the signal is weak and then it progressively increases and then fades away.
Each ramp signal’s duration is 2 sec and then for 3 seconds there is no ramp signal.
So each cycle lasts for 5 seconds and there are 12 cycles /minute which is the respiratory rate.
Significance of the signal in the form of ramp is that it causes progressive expansion of the lungs. After production, these ramp signals are transmitted to the contra lateral motor neurons supplying the inspiratory muscles.
Rate and duration of inspiratory ramp signals is controlled by impulses from the Pneumotaxic centre and impulses from the lungs via vagi.
Regulation of respiration (the guyton and hall physiology)Maryam Fida
Normal respiration is spontaneous and unconscious.
There are 4 groups of neurons on each side in the Pons and medulla oblongata which are involved in regulation of respiration. These include
1. Medullary centers
Dorsal respiratory group of neurons
Ventral respiratory group of neurons
2. Pontine centers
Pneumotaxic centre
Apneustic centre.
It contains “I”neurons which are inspiratory neurons.
It’s located in dorsal portion of medulla oblongata.
It also includes the nucleus of tractus solitarius which is the sensory termination of afferent fibers in 9th ( GLOSSOPHARYNGEAL NERVE) and 10th (VAGUS NERVE) cranial nerves.
They receive impulses from peripheral chemoreceptors, carotid and aortic baroreceptors and also other receptors in the lungs.
In this group inspiratory ramp signals are produced spontaneously.
If we cut the medulla oblongata from other parts of brain and also the afferent nerves which enter the medulla, still inspiratory ramp signals are produced which indicate it’s the inherent property of medulla.
Initially the signal is weak and then it progressively increases and then fades away.
Each ramp signal’s duration is 2 sec and then for 3 seconds there is no ramp signal.
So each cycle lasts for 5 seconds and there are 12 cycles /minute which is the respiratory rate.
Significance of the signal in the form of ramp is that it causes progressive expansion of the lungs. After production, these ramp signals are transmitted to the contra lateral motor neurons supplying the inspiratory muscles.
Rate and duration of inspiratory ramp signals is controlled by impulses from the Pneumotaxic centre and impulses from the lungs via vagi.
Like heartbeat, breathing must occur in a continuous, cyclic pattern to sustain life processes.
Inspiratory muscles must rhythmically contract and relax to alternately fill the lungs with air and empty them.
The rhythmic pattern of breathing is established by cyclic neural activity to the respiratory muscles
Receptor by Pandian M, Tutor, Dept of Physiology, DYPMCKOP, MH. This PPT for ...Pandian M
Introduction
SENSORY RECEPTORS
Structurally 3 types of receptors
Transducers
CLASSIFICATION OF RECEPTORS
A. Depending on the source of stimulus(Sherrington’s classification)
B. Depending upon type of stimulus
C. Clinical or anatomical classification of receptors
Production of receptor potential
Properties of receptors
Properties of receptor potential
6) transport of oxygen and carbon dioxdideAyub Abdi
lecture 6: transportaion of both gases need a hemoglobin and part of them are transported by plasma. if Hb is low the saturation of oxygen also low and leads a hypoxia, fatigue, dyspnea, etc. in other hand acidosis can occur.
Like heartbeat, breathing must occur in a continuous, cyclic pattern to sustain life processes.
Inspiratory muscles must rhythmically contract and relax to alternately fill the lungs with air and empty them.
The rhythmic pattern of breathing is established by cyclic neural activity to the respiratory muscles
Receptor by Pandian M, Tutor, Dept of Physiology, DYPMCKOP, MH. This PPT for ...Pandian M
Introduction
SENSORY RECEPTORS
Structurally 3 types of receptors
Transducers
CLASSIFICATION OF RECEPTORS
A. Depending on the source of stimulus(Sherrington’s classification)
B. Depending upon type of stimulus
C. Clinical or anatomical classification of receptors
Production of receptor potential
Properties of receptors
Properties of receptor potential
6) transport of oxygen and carbon dioxdideAyub Abdi
lecture 6: transportaion of both gases need a hemoglobin and part of them are transported by plasma. if Hb is low the saturation of oxygen also low and leads a hypoxia, fatigue, dyspnea, etc. in other hand acidosis can occur.
This a presentation on regulation of respiration, control of the rate of increase of the the ramp signal, control of the limiting point at which ramp suddenly ceases
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This document contain detailed study about The Regulation of Respiration and it covers all of the aspects of terms and topics related to regulation of respiration.
IT INCLUDES ALL THE RESPIRATORY CENTER IDENTIFIED TILL NOW AND THEIR MODULATION VIA DIFFERENT FACTORS. OVERALL IT EMPHASIS ON HOW CNS CAN ALTER THE FREQUENCY OF RESPIRATION
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http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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2. Respiration is regulated by two
mechanisms:
• Nervous or neural mechanism
• Chemical mechanism
Nervous Mechanism:
• It involves respiratory centers, afferent and efferent nerves.
• Respiratory centers: The centres in the medulla oblongata and
pons that collects sensory information about the level of oxygen
and carbon dioxide in the blood and determines the signals to be
sent to the respiratory muscles.
• Stimulation of these respiratory muscles provide respiratory
movements which leads to alveolar ventilation.
• Respiratory centers are situated in the reticular formation of the
brainstem and depending upon the situation in brainstem, the
respiratory centers are classified into two groups:
1. Medullary centers
2. Pontine centers
3. There are two centers in each group:
• Medullary Centers:
A. Inspiratory center
B. Expiratory center
• Pontine Centers:
A. Pneumotaxic center
B. Apneustic center
4. Inspiratory center:
• Inspiratory center is situated in upper part of medulla
oblongata
• This center is also called dorsal group of respiratory neurons
• It is formed by nucleus of tractus solitarius
• Function: it is concerned with inspiration.
Expiratory center:
• It is situated in medulla oblongata anterior and lateral to the
inspiratory center
• It is also called ventral group of respiratory neurons
• It is formed by neurons of nucleus ambiguous and nucleus
retro ambiguous
• Function: this center is inactive during quiet breathing and
inspiratory center is the active center, but during forced
breathing or when the inspiratory center is inhibited it
becomes active.
5. Pneumotaxic center:
• It is situated in upper Pons.
• It is formed by nucleus parabrachialis.
• Function: it controls medullary respiratory centers,
particularly the inspiratory center through
apneustic center. It always controls the activity of
inspiratory center so that duration of inspiration is
controlled.
Apnuestic center:
• It is situated in lower Pons.
• Function: this center increases depth of inspiration
by acting directly on the inspiratory center.
6. Nervous connections of respiratory
centers:Afferent pathway:
• Respiratory center receive afferent impulses
from different parts of the body according to
movements of thoracic cage and lungs.
• From peripheral chemoreceptor and
baroreceptor impulses are carried by
glossopharyngeal and vagus nerves to
respiratory center.
Efferent pathway:
• Nerve fiber from respiratory center leaves the
brain and descend in anterior part of lateral
column of spinal cord.
• These nerve fibers terminate in the motor
neurons in the anterior horn cells of the cervical
and thoracic segments of spinal cord.
• From motor neurons two sets of nerve fiber
arise which supplies particular muscle:
1. Phrenic nerve fibers: supplies diaphragm
2. The intercostal nerve fibers: supplies
intercostal muscles.
7. Factors affecting respiratory centers:
1) Impulses from higher centers: impulses from
higher center can stimulate or inhibit respiratory
centers directly.
2) Impulses from stretch receptors of lung:
8. 3) Impulses from ‘J’ receptors of lungs:
• ‘J’ receptors are juxtacapillary receptors which are present in wall
of the alveoli and have close contact with the pulmonary
capillaries.
• These receptors get stimulated during conditions like pulmonary
edema, pulmonary congestion, pneumonia as well as due to
exposure of exogenous and endogenous chemicals like histamine,
serotonin.
• Stimulation of ‘J’ receptor produces a reflex response called apnea.
4) Impulses from irritant receptors of lungs:
• Irritant receptors are situated on the wall of bronchi and
bronchioles of lungs.
• They got stimulated by harmful chemicals like ammonia and sulfur
dioxide.
• Stimulation of irritant receptors produces reflex hyperventilation
along with bronchospasm which prevents entry of harmful
chemicals into the alveoli.
9. 5) Impulses from Proprioceptors:
• Proprioceptors are the receptors which give response to the
change in the position of different parts of the body.
• This receptors are situated in joints, muscles and tendons.
They get stimulated during exercise and sends impulses to the
cerebral cortex.
• Cerebral cortex in turn by activating medullary respiratory
centres causes hyperventilation.
6) Impulses from Thermoreceptors:
• Thermoreceptors give response to change in the body
temperature.
• They are cutaneous receptors namely cold and warmth
• When this receptors get stimulated they send signals to
cerebral cortex
• Cerebral cortex in turn stimulates respiratory centres and
causes hyperventilation.
10. 7) Impulses from pain receptors:
• Pain receptors give response to pain stimulus.
• Like other receptors this receptors also send impulses to the
cerebral cortex.
• Cerebral cortex in turn stimulates the respiratory centers ad
causes hyperventilation.
8) Cough reflex:
• This is a protective reflex caused by irritation of parts of the
respiratory tract beyond nose like larynx, trachea and bronchi.
• Irritation of any of this part causes stimulation of vagus nerve
and cough occurs.
• Cough begins with deep inspiration followed by forceful
expiration with closed glottis.
• So the intrapleural pressure rises above 100 mm Hg.
• Then, glottis is suddenly opened with explosive outflow of air
at a higher velocity. So the irritants may be expelled out of
the respiratory tract.
11. 9) Sneezing reflex:
• It is also a protective reflex which occurs due to the irritation
of nasal mucus membrane.
• During irritation of nasal mucus membrane, the olfactory
receptors and trigeminal nerve endings present in the nasal
mucosa are stimulated leading to sneezing.
• Sneezing starts with deep inspiration, followed by forceful
expiratory effort with opened glottis and the irritants are
expelled out of the respiratory tract.
10) Deglutition reflex:
• During swallowing of the food, the respiration is arrested for
a while.
• Temporary arrest of the respiration is called apnea and apnea
which occurs during swallowing called swallowing apnea or
deglutition apnea.
• This prevents entry of the food particles into the respiratory
tract.
12. Chemical Mechanism:
• The chemical mechanism of the respiration is operated
through the chemoreceptors.
Chemoreceptors:
• They are the receptors which give response to change
in the chemical constituents of blood like..
A. Hypoxia
B. Hypercapnea
C. Increased hydrogen ions concentration (decreased
blood pH)
• Chemoreceptors are classified into two groups:
1. Central chemoreceptors
2. Peripheral chemoreceptors
13. Central chemoreceptors
Situation:
• They are situated in deeper part
of medulla oblongata, close to
the dorsal group of neurons.
• This area is known as
chemosensitive area and neurons
are called as chemoreceptors.
• They are in close contact with
blood and CSF.
Action:
• They are very sensitive to increase in
hydrogen ion concentration.
• Hydrogen ion cannot cross the blood
brain barrier and blood cerebrospinal
fluid barrier.
• On the other hand if carbon dioxide
increases in the blood as it is a gas it
can cross both the barrier easily and
after entering the brain it combines
with water to form carbonic acid.
• As carbonic acid is unstable, it
immediately dissociates into hydrogen
and bicarbonate ions.
• The hydrogen ion now stimulates the
central cemoreceptors which
stimulates dorsal group of respiratory
center (inspiratory group) and
increase rate and force of breathing.
The chemoreceptors present in the brain are called central
chemoreceptors.
14. Peripheral chemoreceptors:
Situation: Action:
• They are very sensitive to
reduction in partial pressure
of oxygen.
• Whenever, the partial
pressure of oxygen decreases
these chemoreceptors
become activated and send
impulses to inspiratory
center and stimulate them.
• Thereby increases rate and
force of respiration and
rectifies the lack of oxygen.
The receptors are present in peripheral portions of the body
that’s why called as peripheral chemoreceptors.