The document summarizes the key respiratory centers and mechanisms that control breathing. It discusses:
1) The dorsal respiratory group that controls inspiration and the ventral respiratory group involved in forced expiration. The pneumotaxic center influences inspiration to shut off and the apneustic center prolongs inspiration.
2) Sensory input that influences breathing including stretch receptors in the lungs, chemoreceptors sensitive to oxygen and carbon dioxide levels, and other sensations from the limbic system.
3) Central chemoreceptors in the brainstem that are stimulated by increased carbon dioxide and acidity in the cerebrospinal fluid, while peripheral chemoreceptors in the carotid bodies are stimulated by decreased oxygen and increased carbon
This a presentation on regulation of respiration, control of the rate of increase of the the ramp signal, control of the limiting point at which ramp suddenly ceases
Like heartbeat, breathing must occur in a continuous, cyclic pattern to sustain life processes.
Inspiratory muscles must rhythmically contract and relax to alternately fill the lungs with air and empty them.
The rhythmic pattern of breathing is established by cyclic neural activity to the respiratory muscles
Regulation of Respiration - Animal PhysiologyMuhammad Yousaf
This document contain detailed study about The Regulation of Respiration and it covers all of the aspects of terms and topics related to regulation of respiration.
Regulation of respiration (the guyton and hall physiology)Maryam Fida
Normal respiration is spontaneous and unconscious.
There are 4 groups of neurons on each side in the Pons and medulla oblongata which are involved in regulation of respiration. These include
1. Medullary centers
Dorsal respiratory group of neurons
Ventral respiratory group of neurons
2. Pontine centers
Pneumotaxic centre
Apneustic centre.
It contains “I”neurons which are inspiratory neurons.
It’s located in dorsal portion of medulla oblongata.
It also includes the nucleus of tractus solitarius which is the sensory termination of afferent fibers in 9th ( GLOSSOPHARYNGEAL NERVE) and 10th (VAGUS NERVE) cranial nerves.
They receive impulses from peripheral chemoreceptors, carotid and aortic baroreceptors and also other receptors in the lungs.
In this group inspiratory ramp signals are produced spontaneously.
If we cut the medulla oblongata from other parts of brain and also the afferent nerves which enter the medulla, still inspiratory ramp signals are produced which indicate it’s the inherent property of medulla.
Initially the signal is weak and then it progressively increases and then fades away.
Each ramp signal’s duration is 2 sec and then for 3 seconds there is no ramp signal.
So each cycle lasts for 5 seconds and there are 12 cycles /minute which is the respiratory rate.
Significance of the signal in the form of ramp is that it causes progressive expansion of the lungs. After production, these ramp signals are transmitted to the contra lateral motor neurons supplying the inspiratory muscles.
Rate and duration of inspiratory ramp signals is controlled by impulses from the Pneumotaxic centre and impulses from the lungs via vagi.
Hyperventilation
Respiration
Muscles of respiration
control of respiration
central and peripheral chemoreceptors
effect of exercise on respiration
Effect of respiration on heart rate
Regulation of temperature,respiration and cardiac output andKarishma Sirimulla
This PPT includes reguation of temperature,respiration and gross pictorial description of cardiac cycle and and cardiac output withits pedodontic implications
This a presentation on regulation of respiration, control of the rate of increase of the the ramp signal, control of the limiting point at which ramp suddenly ceases
Like heartbeat, breathing must occur in a continuous, cyclic pattern to sustain life processes.
Inspiratory muscles must rhythmically contract and relax to alternately fill the lungs with air and empty them.
The rhythmic pattern of breathing is established by cyclic neural activity to the respiratory muscles
Regulation of Respiration - Animal PhysiologyMuhammad Yousaf
This document contain detailed study about The Regulation of Respiration and it covers all of the aspects of terms and topics related to regulation of respiration.
Regulation of respiration (the guyton and hall physiology)Maryam Fida
Normal respiration is spontaneous and unconscious.
There are 4 groups of neurons on each side in the Pons and medulla oblongata which are involved in regulation of respiration. These include
1. Medullary centers
Dorsal respiratory group of neurons
Ventral respiratory group of neurons
2. Pontine centers
Pneumotaxic centre
Apneustic centre.
It contains “I”neurons which are inspiratory neurons.
It’s located in dorsal portion of medulla oblongata.
It also includes the nucleus of tractus solitarius which is the sensory termination of afferent fibers in 9th ( GLOSSOPHARYNGEAL NERVE) and 10th (VAGUS NERVE) cranial nerves.
They receive impulses from peripheral chemoreceptors, carotid and aortic baroreceptors and also other receptors in the lungs.
In this group inspiratory ramp signals are produced spontaneously.
If we cut the medulla oblongata from other parts of brain and also the afferent nerves which enter the medulla, still inspiratory ramp signals are produced which indicate it’s the inherent property of medulla.
Initially the signal is weak and then it progressively increases and then fades away.
Each ramp signal’s duration is 2 sec and then for 3 seconds there is no ramp signal.
So each cycle lasts for 5 seconds and there are 12 cycles /minute which is the respiratory rate.
Significance of the signal in the form of ramp is that it causes progressive expansion of the lungs. After production, these ramp signals are transmitted to the contra lateral motor neurons supplying the inspiratory muscles.
Rate and duration of inspiratory ramp signals is controlled by impulses from the Pneumotaxic centre and impulses from the lungs via vagi.
Hyperventilation
Respiration
Muscles of respiration
control of respiration
central and peripheral chemoreceptors
effect of exercise on respiration
Effect of respiration on heart rate
Regulation of temperature,respiration and cardiac output andKarishma Sirimulla
This PPT includes reguation of temperature,respiration and gross pictorial description of cardiac cycle and and cardiac output withits pedodontic implications
Similar to Regulation_of_respiration_physiology_6-12-2018.pptx (20)
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5. 4
Inspiratory center (dorsal respiratory group, DRG)
•more frequently they fire, more deeply you
inhale
•longer duration they fire, breath is prolonged,
slow rate
Expiratory center (ventral
respiratory group, VRG)
•involved in forced
expiration
6. 5
Pneumotaxic center (upper pons)
•Sends continual inhibitory impulses to inspiratory
center of the medulla oblongata,
•As impulse frequency rises, breathe faster and
shallower
Apneustic center (lower pons)
•Stimulation causes apneusis
• Integrates inspiratory cutoff
information
9. 8
2. Rhythmic Ventilation (Inspiratory Off Switch)
• Starting inspiration
– Medullary respiratory center neurons are
continuously active (spontaneous)
– Center receives stimulation from receptors and
brain concerned with voluntary respiratory
movements and emotion
– Combined input from all sources causes action
potentials to stimulate respiratory muscles
10. 9
•Increasing inspiration
–More and more neurons are activated
•Stopping inspiration
–Neurons receive input from pontine group and
stretch receptors in lungs.
–Inhibitory neurons activated and relaxation of
respiratory muscles results in expiration.
–Inspiratory off switch.
13. • Dorsal Respiratory Group—
Quiet inspiration
• Ventral Respiratory Group—Forceful
inspiration and active expiration
• Pneumotaxic Center—Influences
inspiration to shut off
• Apneustic Center—Prolongs
inspiration
14. A. Sensory Input
(1) Lung via the vagus nerve:
stretch receptors (smooth muscle)
Volume
irritant receptors (airway)
Cough and Sneeze reflex
J receptors (“juxtacapillary receptors”)
Emboli
(2) Muscles—muscle spindles
B. Chemoreceptors
C.Other sensations (pain, emotions)- limbic system
and hypothalamus
D. Voluntary control of breathing-Cerebral cortex
17. • Central Chemoreceptors
– Responsive to increased arterial PCO2
– Act by way of CSF [H+] .
• Peripheral Chemoreceptors
– Responsive to decreased arterial PO2
– Responsive to increased arterial PCO2
– Responsive to increased H+ ion concentration.
16
21. 20
• Carotid bodies
– Sensitive to: PaO2, PaCO2, and pH
– Afferents in glossopharyngeal nerve.
• Aortic bodies
– Sensitive to: PaO2, PaCO2, but not pH
– Afferents in vagus
23. • High flow per unit weight:
(2 L/min/100 g)
• High carotid body VO2 consumption:
(8 ml O2/min/100g)
• Tiny a-v O2 difference
• Responsiveness begins at PaO2 (not the oxygen
content) below about 60 mmHg.
22
27. 26
• Peripheral chemoreceptors sensitive to PO2,
PCO2 and pH
• Receptors are activated by increase in
PCO2 or decrease in PO2 and pH
• SendAPs through sensory neurons to the brain
• Sensory info is integrated within the medulla
• Respiratory centers respond by sending
efferent signals through somatic motor
neurons to the skeletal muscles
• Ventilation is increased
28. 27
pH of CSF (most powerful respiratory stimulus)
Respiratory acidosis (pH < 7.35) caused by failure
of pulmonary ventilation
– hypercapnia (PCO ) > 43 mmHg
2
– CO2 easily crosses blood-brain barrier, in CSF the CO2
reacts with water and releases H+, central
chemoreceptors strongly stimulate inspiratory center
– corrected by hyperventilation, pushes reaction to the
left by “blowing off ” CO2
CO2 (expired) + H2O H2CO3 HCO3 + H
- +
29. 28
• Indirect effects
– through pH (central chemoreceptor)
• Direct effects
– CO2 may directly stimulate peripheral
chemoreceptors and trigger ventilation more quickly
than central chemoreceptors
• If the PCO2 is too high, the respiratory center will
be inhibited.
30. 29
• Direct inhibitory effect of hypoxemia on the
respiratory center
• Chronic hypoxemia, PO2 < 60 mmHg, can
significantly stimulate ventilation
– Emphysema , pneumonia
– high altitudes after several days
35. • Normal adults. Receptors are not activated at end
normal tidal volumes.
– Become Important during exercise when tidal volume is
increased.
– Become Important in Chronic obstructive lung diseases
when lungs are more distended.
• Infants. Probably help terminate normal inspira3
ti
4on.