Digital subtraction pulmonary angiography (DSPA) is the definitive test for evaluating diseases of the pulmonary vasculature like pulmonary embolism. It allows visualization of all pulmonary arterial branches and therapeutic interventions. DSPA involves percutaneous venous catheterization and injection of iodinated contrast agents to produce images of the pulmonary arteries and veins. While it remains the criterion standard, DSPA has risks like acute cor pulmonale in patients with pulmonary hypertension and operator dependency remains a concern due to potential 10-15% interobserver variability in examining small vessels.