Diagnostic catheters for coronary angiography Aswin Rm
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Overview of diagnostic catheters used in coronary angiography
Guide catheters not included
History of coronary catheters
Radial techniques and catheters
Foreign body removal during cardiac catheterizationRamachandra Barik
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The removal of foreign bodies from the heart and vasculature has shifted from the domain of the radiologist and even the thoracic or vascular surgeon to the terventional cardiologist and, in turn, from the radiographic suite or operating room to the cardiac catheterization Laboratory.
Diagnostic catheters for coronary angiography Aswin Rm
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Overview of diagnostic catheters used in coronary angiography
Guide catheters not included
History of coronary catheters
Radial techniques and catheters
Foreign body removal during cardiac catheterizationRamachandra Barik
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The removal of foreign bodies from the heart and vasculature has shifted from the domain of the radiologist and even the thoracic or vascular surgeon to the terventional cardiologist and, in turn, from the radiographic suite or operating room to the cardiac catheterization Laboratory.
rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Coronary CTO is characterized by heavy atherosclerotic plaque burden within the artery, resulting in complete (or nearly complete) occlusion of the vessel. Although the duration of the occlusion is difficult to determine on clinical grounds, a total occlusion must be present for at least 3 months to be considered a true CTO. Patients with CTO typically have collateralization of the distal vessel on coronary angiography, but these collaterals may not provide sufficient blood flow to the myocardial bed, resulting in ischemia and anginal symptoms. CTO is clinically distinct from acute coronary occlusion, which occurs in the setting of ST-segmentâelevation myocardial infarction, or subacute coronary occlusion, discovered with delayed presentation after ST-segmentâelevation myocardial infarction. Clinical features and treatment considerations of these entities differ considerably from CTO.
Among patients who have a clinical indication for coronary angiography, the incidence of CTO has been reported to be as high as 15% to 30%. Patients with CTO are referred for angiography because of anginal symptoms or significant ischemia on noninvasive ischemia testing. Patients who are symptomatic will have stable exertional angina resulting from a limitation of collateral vessel flow to meet myocardial oxygen demand with stress. Of patients referred for PCI in clinical trials of CTO PCI, only 10% to 15% of patients are asymptomatic. It is likewise uncommon for patients with CTO to present with an acute coronary syndrome caused by the CTO itself.
rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Coronary CTO is characterized by heavy atherosclerotic plaque burden within the artery, resulting in complete (or nearly complete) occlusion of the vessel. Although the duration of the occlusion is difficult to determine on clinical grounds, a total occlusion must be present for at least 3 months to be considered a true CTO. Patients with CTO typically have collateralization of the distal vessel on coronary angiography, but these collaterals may not provide sufficient blood flow to the myocardial bed, resulting in ischemia and anginal symptoms. CTO is clinically distinct from acute coronary occlusion, which occurs in the setting of ST-segmentâelevation myocardial infarction, or subacute coronary occlusion, discovered with delayed presentation after ST-segmentâelevation myocardial infarction. Clinical features and treatment considerations of these entities differ considerably from CTO.
Among patients who have a clinical indication for coronary angiography, the incidence of CTO has been reported to be as high as 15% to 30%. Patients with CTO are referred for angiography because of anginal symptoms or significant ischemia on noninvasive ischemia testing. Patients who are symptomatic will have stable exertional angina resulting from a limitation of collateral vessel flow to meet myocardial oxygen demand with stress. Of patients referred for PCI in clinical trials of CTO PCI, only 10% to 15% of patients are asymptomatic. It is likewise uncommon for patients with CTO to present with an acute coronary syndrome caused by the CTO itself.
Initial experience with the Glidesheath Slender for transradial coronary angiography and intervention: a feasibility study with prospective radial ultrasound follow-up
QA Paediatric dentistry department, Hospital Melaka 2020Azreen Aj
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QA study - To improve the 6th monthly recall rate post-comprehensive dental treatment under general anaesthesia in paediatric dentistry department, Hospital Melaka
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
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Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
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This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
Welcome to Secret Tantric, Londonâs finest VIP Massage agency. Since we first opened our doors, we have provided the ultimate erotic massage experience to innumerable clients, each one searching for the very best sensual massage in London. We come by this reputation honestly with a dynamic team of the cityâs most beautiful masseuses.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
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Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
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M Capital Group (âMCGâ) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, âDespite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.â
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (âMTIâ) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, weâll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
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Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.Â
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctorsâ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
 Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratoryÂ
 to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
2. INTRODUCTION
⢠The idea of atherectomy is to reduce the plaque burden
without affecting the rest of the vessel wall.
⢠Atherectomy technique debulks & remove
atherosclerotic plaque by cutting, pulverizing, vaporizing
or shaving with catheter deliverable devices.
⢠They offer theoretical advantages of eliminating stretch
injury, limiting acute dissection (& the need for
adjunctive stenting) & reducing elastic recoil, thereby
potentially reducing the rate of restenosis.
3. Differential Cutting DIFFERENTIAL CUTTING
The ability to cut one material
while sparing another based on
differences in composition.
ELASTIC TISSUE
Normal vascular tissue has elastic
properties that allow it to deflect
away from the advancing
diamonds on the rotating burr.
INELASTIC TISSUE
Selectively ablates inelastic tissue
(i.e. plaque) whether composed of
calcium, fibrotic tissue, neointima
or lipid-rich material.
Elastic Tissue
Inelastic Tissue
Results in preferential cutting of inelastic substrate
are functional at low and high speeds
PRINCIPLE
5. âHistorically, neither rotational nor
directional atherectomy has shown any
significant long term benefit over PTA alone
in the coronary or peripheral arteriesâ
- ARTIST Trial; Jueren et al.
Results of the Angioplasty versus rotational atherectomy for treatment of
diffuse in-stent re-stenosis trial (ARTIST Trial) Circulation. 2002; 105:583-588
6. Directional atherectomy systems
⢠SilverHawk & TurboHawk
⢠US Food and Drug Administration-approved.
⢠Approved for peripheral vasculature & not for
coronary, carotid, iliac, or renal arteries.
⢠Minimally invasive treatment that removes plaque
7. SilverHawk plaque excision system
⢠Forward cutting directional atherectomy device.
⢠Used with or without concurrent percutaneous
balloon angioplasty and stenting.
⢠Consists of a rotating blade inside a tubular housing
with a collection area (nosecone).
⢠This catheter is connected to a battery-driven motor
which spins the cutter.
11. TurboHawk system
⢠Similar except in the no. of inner blades (four
contoured blades)
⢠Favors use in highly calcified lesions and more plaque
removal per pass.
12. Directional atherectomy systems
⢠Both devices come in various sizes to enable
atherectomy in vessels with diameters of 1.5â7
mm.
⢠SilverHawk has advantage of directional control
for eccentric lesions.
⢠As the device is advanced, plaque is excised &
packed in the nosecone.
⢠Distal embolization remains a major problem.
15. CLINICAL DATA
⢠TALON (Treating PeripherAls with SiLverHawk: Outcomes
CollectioN) registry
⢠601 patients with over 1,258 infrainguinal lesions
⢠Patients with both claudication and critical limb ischemia.
⢠Both above- & below-knee lesions were treated.
⢠Achieved 50% or less diameter stenosis in 94.7% lesions.
⢠The procedural success rate was 97.6%.
⢠Stent placement was required in only 6.3% lesions
⢠6- & 12-mo. survival free of TLR rates were 90% & 80%,
respectively.
16. CLINICAL DATA
⢠DEFINITIVE LE (Determination of Effectiveness of
SilverHawk Peripheral Plaque Excision [SilverHawk
Device] for the Treatment of Infrainguinal
Vessels/Lower Extremities) registry â largest ever
conducted across 50 sites US & Europe
⢠Enrolled 799 patients with both claudication and CLI.
⢠Lesions up to 20 cm in length and multilevel lesions
⢠Success was reported at 89%, with a post-atherectomy
BA rate of 33% & bail-out stenting rate of 3%.
17. ⢠Rates of distal embolization, dissection &
perforation were 3.8%, 2.3% & 5.3%
⢠All-complication rate needing treatment was 7.6%.
⢠At 12 months, SFA patency was 83% & IFA patency
was 78%.
⢠Limb salvage rate in CLI patients was 95%.
⢠Diabetics performed equally well as compared to
nondiabetics.
18. Rotational atherectomy
⢠Consists of an elliptical, nickel-plated, brass burr
⢠Coated with 2,000â3,000 microscopic diamond
crystals on the leading edge
⢠Available burr sizes are; 1.25, 1.5, 1.75, 2.0, 2.15,
2.25, 2.38, and 2.5 mm
⢠Burr rotates at 140,000â190,000 rpm
⢠Burr is advanced over the RotaWire
20. ⢠Wire clip torquer should be placed to prevent the
guide wire from spinning
⢠A cocktail of RotaglideŽ lubricant (nitroglycerine,
verapamil, and heparin) infuses through the Teflon
sheath which minimizes vasospasm, cools the
turbine, lubricates the driveshaft, and flushes the
particulate
⢠DIFFERENTIAL CUTTING
⢠Debris generated is < 10 Οm, which traverses the
coronary microvasculature & is cleared by RES
21.
22.
23. Clinical data
⢠Single center Excimer Laser, Rotational Atherectomy, and
Balloon Angioplasty Comparison (ERBAC) study,
⢠685 patients randomized to various atherectomy methods
⢠RA had the greatest initial success â 89% (RA) versus 77%
(excimer laser) versus 80% (BA)
⢠No difference in major in-hospital complications & at 6-mo.
follow-up.
⢠TLR was more frequent in the RA (42.4%) & the excimer
laser group (46.0%) than angioplasty group (31.9%,
P=0.013)
24. ⢠Multicenter, prospective, comparison of balloon
angioplasty vs rotational atherectomy in complex
coronary lesions (COBRA) trial
⢠502 patients were enrolled
⢠Similar results were found
25. Currently, due to lack of benefit in preventing
restenosis in native & restenotic lesions,
âRA is used to prepare the calcified lesions for
stenting (drug eluting stents) when the stent is not
deliverable/expandable or the lesion is not dilatable
with conventional BAâ
26. Absolute contraindications to RA are:
â Saphenous vein graft lesions;
â Presence of thrombus;
â Dissection; and
â Inability to cross the lesion with the guide wire.
Relative contraindications include:
â Lesion length > 25 mm;
â Lesion angulation > 45°;
â Severe LV dysfunction;
â Severe TVD or unprotected LM disease; and
â No candidacy to CABG, either because of patient
ineligibility or lack of onsite surgical backup
27. ⢠Some of the reported complications of RA are:
â Q wave myocardial infarction (MI) (0.8%),
â Urgent CABG(2.0%),
â Non-Q MI (8.9%),
â Acute closures (1.1%),
â Slow flow (2%),
â Perforation (1.0%),
â Side-branch closure (5%),
â Dissection (4%), and
â Spasm (5%).
⢠Peripheral rotablator atherectomy has also recently
started being used for calcified below-knee arteries
28. Pathway Jetstream PV
Atherectomy System
⢠Pathway Jetstream PV Atherectomy System
(Pathway Medical Technologies)
⢠Consists of a single-use catheter with control pod
and a reusable, compact console
⢠The system is indicated for both thrombectomy and
RA by the same catheter
29. ⢠The catheter is advanced maximum rate of 1
mm/second to avoid significant drops in rotational
speeds
⢠It has a front-cutting tip that makes it go through
tight lesions without predilation
⢠The electric motor spins for every 40 sec f/b a 10 sec.
pause.
30. ⢠During treatment, saline solution is delivered to the
proximal end of the catheter using two lines:
â To flush the motor assembly to maintain airtight seal for
embolic protection;
â To infuse in the treatment area at the distal body of the
catheter to facilitate the catheterâs debulking and
aspiration capabilities
⢠Its differentially cutting catheter
31. ⢠Above-knee catheters
â 2.1 mm/3.0 mm and 2.4 mm/3.4 mm have a catheter tip
that remains at a defined nominal diameter (2.1mm orâ2.4
mm) when spinning clockwise, but
â expands to a defined maximum diameter (3.0 mm or 3.4
mm, respectively) when rotating counterclockwise
⢠For the below-knee use, there are fixed cutters
(single cutter) with sizes of 1.6 mm and 1.85 mm
32.
33.
34.
35. ⢠Pathway Jetstream is the only atherectomy device to
offer continuous active aspiration, and actively
removes atherosclerotic debris and thrombus from
the treatment site and delivers it to a collection bag
located on the console.
36. CLINICAL DATA
⢠Zeller et al21
⢠Treatment of 172 patients â 210 lesions
(femoropopliteal and infrapopliteal vessels) â
⢠99% device success at 6-month and 12-month
⢠TLR rates of 15% and 26%, respectively.
⢠The 1-year restenosis rate was 38.2%
37. ⢠In a review of 2,137 lesions treated in 1,029 patients,
⢠Jetstream devices had a combined embolization rate
of 22% (eight of 36), four of 18 (22%) in each group,
which was significantly higher than with BA alone
(five of 570, 0.9%),
⢠The use of embolization protection may be beneficial
when using this device.
39. EXCIMER LASER ATHERECTOMY
⢠Uses high energy, monochromatic light beam to alter or
dissolve (vaporize) the plaque without damaging the
surrounding tissue.
⢠Fiber-optic catheters are used to deliver this light beam.
⢠For endovascular applications, xenon chloride excimer
laser is used and its fiber-optic catheter has multiple
small fibers, in order to be flexible enough to navigate in
the arterial tree
⢠Laser can be used in both coronary and peripheral
applications
40. ⢠It uses ultraviolet (UV) B region with a shorter
wavelength (300 nm), the absorption depth is less
⢠Another advantage is, it uses direct photochemical
lytic affect to break molecular bonds rather than
thermal affect
⢠UV B photons absorbed by the proteins and lipids in
cells actually break chemical bonds which facilitates
lyses of cellular structures
41. ⢠When laser is used, two factors are controlled by the
operators:
â number of pulses per second (frequency) given and
â energy amount (fluence)
⢠the high energy is delivered with short interaction
time (pulsed).
⢠In this way, chemical bonds are broken only in the
tissue that the laser is touching without damaging
surrounding material or increasing the heat
42. ⢠The excimer laser catheter removes tissue with a
thickness of 10 Îźm with each pulse of energy.
⢠Pulsed-wave xenon chloride laser is commonly used
in clinical practice;
⢠it operates within a wavelength of 308 nm, with
relatively long pulses (pulse duration of 135
nanoseconds),
⢠produces an output of 165 mJ per pulse.
43. ⢠The long pulse length is required for successful delivery of
the UV light by silica fibers at the fluences necessary for
therapy â typically between 30 and 80 mJ/mm2.
⢠After this pulse of 135 nanoseconds, laser energy is not
emitted.
⢠Typically, pulse repetition rates of 25â40 pulses/second
are used.
⢠By doing this, the total power emitted from the catheter
tip is less than 3 W for the largest catheters and this
minimizes thermal effects during the tissue-ablation
process
44. ⢠The size of the laser catheters used are chosen based
on reference coronary/peripheral vessel diameter,
and available sizes are 0.9 mm, 1.4 mm, 1.7 mm, 2.0
mm, 2.3 mm, and 2.5 mm.
⢠While using excimer laser, advancement of the
catheter should be slow (0.5 mm/second and no
faster than 1 mm/second) for effective plaque
removal due to shallow penetration energy depth
(35â50 Îźm).
45. ⢠iodinated dye absorbs the excimer laser energy nearly
completely and will cause cavitation bubbles, vapor
bubbles, and percussive waves which will lead to
dissections/perforations,
⢠laser catheter should never be activated in contrast
media
⢠blood (hemoglobin) strongly absorbs excimer laser light
at 308 nm.
⢠saline flushes need to be given in order to remove blood
and contrast
46. ⢠The excimer laser has been also used to facilitate
crossing of the wire through chronic total occlusions
by using the âstep-by-stepâ technique
⢠There are newer designs for ablating larger lumen,
such as the TURBO-Booster catheter (Spectranetics)
which uses a custom guide catheter that allows the
laser to move in different directions and ablate more
tissue.
47.
48. CLINICAL DATA
⢠CARMEL multicenter study, excimer laser angioplasty
was successfully used in more than 90% of the
enrolled 151 acute myocardial infarction (AMI)
patients with a large thrombus burden with a
relatively low rate (8.6%) of major cardiac adverse
events (MACE).
⢠For in-stent restenosis: in the Laser Angioplasty for
Restenotic Stents multicenter registry (LARS), laser
angioplasty reduced 30-day repeat-target-site
coronary intervention, but it did not decrease in 1
year
49. ⢠CORAL study, excimer laser atherectomy was used in
diseased vein grafts with comparable 30-day MACE
(18.4%) to that of the control population (19.4%) from
the SAFER trial.
⢠It is important to notice that use of a distal embolic
protection device in the SAFER trial, where the filter wire
was used, showed a reduction of MACE (42% relative
reduction) compared to the control group, which further
supports the use of the protection device
⢠The device was studied in the multicenter clinical trial
ClirPath Excimer Laser to Enlarge Lumen Openings
(CELLO) with high procedural success rate,
50. ⢠It can also be used to assist endovascular treatment
of peripheral arterial disease.
⢠In the Laser Angioplasty for Critical Limb Ischemia
(LACI) trial, 155 critically ischemic limbs with above-
or below-knee disease that were poor candidates for
surgical revascularization were treated.
⢠Despite the fact that mean treatment length was .16
cm and most of the patients had multiple
stenosis/occlusions, a limb-salvage rate of 93% was
achieved at 6 months.
51. ORBITAL ATHERECTOMY
⢠Diamondback 360° OAS is very similar to RA devices,
as it uses a crown that is equivalent to the RA burr
⢠The crown is eccentrically mounted, diamond coated,
and rotates at speeds varying from 60,000 to 200,000
rpm
⢠OAS uses its unique orbiting action to remove plaque,
and it has the ability to increase lumen diameter by
increasing the orbital speed
52. ⢠A crown is eccentric in shape, in contrast to an RA
burr
⢠Theoretically, the less diseased, more elastic arterial
wall flexes away from the crown and minimizes the
risk of vessel trauma
⢠Perhaps the most-unique feature of OA is the ability
to create variable lumen size with the same catheter
by only changing the speed of rotation
⢠used in diseased peripheral, coronary arteries and in
diseased artificial arteriovenous dialysis fistulae
53. ⢠Some other advantages of the orbital motion of the
crown is
â its being in contact with only one part of the vessel wall at
any given moment, and
â not obstructing flow in a diseased vessel (100% occluded
vessel which does not have flow anyway),
â which will minimize heat generation and also lead to the
â continuous clearance of the sanded microscopic particulate
matter rather than having it build up into a large load of
matter
⢠Crowns come in sizes of 1.25, 1.5, 2.0, and 2.25 mm.
The crowns need to be advanced over the wire. As a
guide wire, ViperWire is used
54.
55.
56. Clinical data
⢠CONFIRM registry series (I, II, and III) to evaluate the use
of OA in peripheral lesions of the lower extremities.
⢠3,135 patients undergoing OA by more than 350
physicians at over 200 US institutions on an âall-comersâ
basis.
⢠OA reduced preprocedural stenosis from 88%¹12% s to
an average of 10% with adjunctive treatments, typically
low-pressure BA.
⢠Plaque removal was most effective for severely calcified
lesions and least effective for soft plaque
57. ⢠dissection (11.3%),
⢠spasm (6.3%),
⢠slow flow (4.4%),
⢠embolism (2.2%),
⢠vessel closure (1.5%),
⢠thrombus (1.2%), and
⢠perforation (0.7%).52
⢠Other complications reported with OA use are
hemolysis and hemolysis-induced pancreatitis
58. âAtherrectomy devices are a good
alternative when the traditional measures
of angioplasty fails but should not not be
used as a first hand measure to treat a
lesionâ
Circulation 2002 âAtherectomy devices and their futureâ