3D echocardiography provides several advantages over 2D echocardiography including showing the real-time 3D structure of the heart, easier demonstration of anatomy, and more accurate volumetric measurements without relying on geometric assumptions. Modern 3D transducers contain thousands of piezoelectric elements. Different acquisition modes such as live 3D, full volume, and 3D color Doppler allow visualization of cardiac structures from different angles in real-time or through offline analysis. While 3D echocardiography provides valuable clinical information, limitations include artifacts from arrhythmias and breathing, lower spatial and temporal resolution compared to 2D, and more complex data analysis.
Diagnostic catheters for coronary angiography Aswin Rm
Overview of diagnostic catheters used in coronary angiography
Guide catheters not included
History of coronary catheters
Radial techniques and catheters
There are many interventional cardiac procedure those need a trans septal puncture of the interatrial septum. This presentation clearly elaborates everything you need to know about the TSP.
Diagnostic catheters for coronary angiography Aswin Rm
Overview of diagnostic catheters used in coronary angiography
Guide catheters not included
History of coronary catheters
Radial techniques and catheters
There are many interventional cardiac procedure those need a trans septal puncture of the interatrial septum. This presentation clearly elaborates everything you need to know about the TSP.
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
Percutaneous Balloon Mitral Valvuloplasty (PBMV) is a procedure to dilated the mitral valve in the setting of rheumatic mitral valve stenosis. A catheter is inserted into the femoral vein, advanced to the right atrium and across the interatrial septum. Then the mitral valve is crossed with a balloon and it is inflated to relieve the fusion of the mitral valve commissures effectively acting to increase the mitral valve area and reduce the degree of mitral stenosis. Mitral regurgitation is a potential complication and thus PBMV is contraindicated if moderate or severe regurgitation is present. The Wilkins score examines mitral valve morphology and is determined via echocardiography to assess the likelihood of using PBMV based on certain echocardiographic criteria.
Automatic meas in clinical daily practice bcu event Harry Ridwan
This guideline recommends, when practicable, use of longitudinal strain imaging (GLS) and three-dimensional (3D) evaluation of ventricular size and function as part of the standard TTE examination – JASE December 2018
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
Percutaneous Balloon Mitral Valvuloplasty (PBMV) is a procedure to dilated the mitral valve in the setting of rheumatic mitral valve stenosis. A catheter is inserted into the femoral vein, advanced to the right atrium and across the interatrial septum. Then the mitral valve is crossed with a balloon and it is inflated to relieve the fusion of the mitral valve commissures effectively acting to increase the mitral valve area and reduce the degree of mitral stenosis. Mitral regurgitation is a potential complication and thus PBMV is contraindicated if moderate or severe regurgitation is present. The Wilkins score examines mitral valve morphology and is determined via echocardiography to assess the likelihood of using PBMV based on certain echocardiographic criteria.
Automatic meas in clinical daily practice bcu event Harry Ridwan
This guideline recommends, when practicable, use of longitudinal strain imaging (GLS) and three-dimensional (3D) evaluation of ventricular size and function as part of the standard TTE examination – JASE December 2018
Speckle tracking echocardiography (STE) is an echocardiographic imaging technique that analyzes the motion of tissues in the heart by using the naturally occurring speckle pattern in the myocardium or blood when imaged by ultrasound.
Future of Echocardiography: Unlocking the Power of Volume ImagingTrimed Media Group
Join Dr. Dinesh Thavendiranathan of the University of Toronto for a discussion on 3D volume echocardiography in the left heart. Hear how volume echocardiography enables the acquisition of an entire volume of the heart in a single full cardiac cycle and facilitates faster and more accurate analysis via full automation of endocardial contours. Also learn about workflow improvements, more reproducible echo exams and ways to save costs
Improving patient care along with quality service and at the same time cutting costs might seem totally opposite goals, but that is exactly the promise of telemedicine. The term telemedicine covers an ever increasing number of techniques that put patients in touch with medical expertise over great distances. Techlead Software Engineering Pvt. Ltd. India is coming up with one stop solution for ophthalmologist, the Digitech Ophthalmologist.
Digitech Ophthalmologist
Digital ophthalmologist is a software tool developed by Techlead software Engineering. It has been developed with understanding of the ophthalmologist’s concerns. This smart assistant to doctors will perform many of their routine and time consuming tasks in a much efficient way.
Panorama ConstructionCDR AnalysisGlaucoma DetectionBlood Vessel Analysis3D Retina ReconstructionRetinopathy
Digital Tomosynthesis: Theory of OperationCarestream
Digital Tomosynthesis (DT) is a new radiographic imaging technique that is revived from the nearly century-old traditional film-screen tomography. This rejuvenation is all made possible by the recent advances in high frame-rate, high-sensitivity flat-panel digital radiographic detector, rapid pulsed-exposure sequence-capable high-frequency x-ray generator, the widely available and low-cost computer GPU processing power, and the precision motion controls built in the digital radiography system hardware. Read the white paper.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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4. Why 3D Echocardiography?
▪ 3D structure of the heart and relation of various structures
▪ Easier to demonstrate to those who are echo-challenged
▪ No need to rely on geometric assumptions when
quantifying volumes, mass, function
▪ Potentially faster image acquisition
• Presentation of realistic views of heart valves
• Volumetric evaluation of regurgitant lesions and shunts
with 3DE color Doppler imaging
• 3DE stress imaging
5.
6.
7.
8.
9. Fully Sampled Matrix-Array Transducers
▪ Development of fully sampled matrix-array
transducers in 2000.
▪ Currently, 3DE matrix-array transducers are
composed of nearly 3,000 piezoelectric
elements
Frequencies
▪ TTE 2-4 MHZ
▪ TEE 5-7 MHz
▪ Single transducer to acquire both 2D and 3DE
studies.
10.
11. 2D Image Optimization
Mode Selection
Adjustments
Final display
Online/Offline analysis
Real-time or live
3DE imaging
Live 3D
(Narrow)
Live 3D
zoomed
Live 3D
(full volume)
Live 3D color
Doppler
Multiple-beat
3DE imaging
.
Modes
13. Single Beat
•Advantage
–Overcomes limitations from rhythm disturbances and
respiratory motion
•Disadvantage
–Limited by poor temporal resolution
Multi-beat
•Advantage
–Images with higher temporal resolution
•Disadvantage
–Gated images are susceptible to artifacts from respiratory
motion or cardiac arrhythmias
Single or Multi-beat?
14. Multiplane Mode (X-Plane)
Not true 3D modality
Dual screen to simultaneously display two real-time images.
– Rreference plane
– Lateral plane
▪ 30 to 150 degrees from the reference plane.
▪ Multiplane imaging in the elevation plane is also available.
▪ Color flow Doppler imaging can also be superimposed onto
the 2D images.
15.
16.
17.
18.
19.
20.
21. Real-Time 3D Mode—Narrow Sector
▪ Real-time display of a 30 x 60 degrees pyramidal volume.
▪ Narrow sector --- insufficient to visualize the entirety of a
single structure in any one imaging plane
▪ Superior spatial and temporal resolution
▪ Easy to use
▪ Better for valves and small structures
22.
23.
24.
25.
26. 3D ZOOM (Focused,Wide Sector)
▪ Focused to area of interest
▪ Wide sector view of cardiac structures
▪ Better for valves and IAS
▪ Decreased spatial and temporal resolution relative to real-time 3DE
▪ Used to cardiac interventions
▪ Best to visualize valves
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42. Full Volume—Gated Acquisition
▪ Largest acquisition sector possible
▪ (up to 100° x 100°)
▪ Optimal spatial resolution
▪ High temporal resolution (30 Hz).
Similar to the real-time 3D and the
focused wide sector—“ZOOM”
modalities
▪ Cropping and off-line analysis. (Top) Example of electrocardiographically triggered multiple-beat 3DE data acquisition from a transthoracic apical window. Narrow
pyramidal volumes from four cardiac cycles (top left) are stitched together to form a single volumetric data set (top right). (Bottom)
Real-time or live 3DE single-beat acquisition of the whole heart (bottom left) and the left ventricle (bottom right) from the
transthoracic apical window.
43. Full Volume—Gated Acquisition
▪ Multiple-beat 3D echocardiography
– Higher temporal resolution
– Multiple acquisitions of narrow volumes
of data over several heartbeats that are
subsequently stitched together to
create a single volumetric data set
– Prone to imaging artifacts created by
patient or respiratory motion or
irregular cardiac rhythms.
44.
45. Full Volume with Color Flow Doppler
▪ 3D plus Color
▪ Initially only for Full volume mode with 7-14 beats volume
stitched together.
▪ Currently 3D color full volume can be acquired with as low as
single beats but at the cost of temporal resolution.
▪ Used for quantification of regurgitant jets
46.
47.
48. Limitations
▪ Poor spatial and temporal resolution
▪ Currently, live 3DE color Doppler acquisition is limited to small
color Doppler volumes, usually with limited temporal resolution of
10 to 15 voxels/sec.
▪ Alternatively, multiple-beam full-volume acquisition of color
Doppler providing larger color Doppler volumes and volume rates
(up to 40 voxels/sec) are limited by stitching artifacts.
49.
50.
51.
52. Challenges with 3DE Acquisition
TemporalVersus Spatial Resolution
▪ The main trade-off in 3DE imaging is between
volume rate (i.e., temporal resolution) and
spatial resolution.
▪ Fortunately, imaging volumes can be adjusted in
size (i.e., made smaller) to increase volume rate
while maintaining spatial resolution.
53. ▪ Gated data sets are most challenging in
patients with arrhythmias and/or
respiratory difficulties.
▪ ECG tracing needs to be optimized to
obtain a distinct R wave
▪ Stitching artifacts
Challenges with 3DE Acquisition
ECG Gating and Breath Hold
57. 3DE Image Display: Cropping
▪ Cropping is inherent to 3D echocardiography.
▪ Different fromTomography
▪ From difficult cross sectional views to surgical
views
▪ Cropping can be performed either during
procedure or later
▪ Advantages of cropping during procedure
58. Multiplanar reconstruction of a rheumatic, stenotic mitral valve imaged with zoomed, transesophageal 3D echocardiography (bottom
right). Orthogonal cut planes through the narrowest mitral valve orifice in mid-diastole (top left and right) with a perpendicular plane
providing an en face image for mitral valve area (MVA) measurement (bottom left).
59. Post-Acquisition Display
Once a 3DE data set is acquired, it can be viewed interactively using a
number of 3D visualization and rendering software packages.
Display of 3DE images can be divided into three broad categories:
(1) volume rendering
(2) surface rendering (including wireframe display
(3) 2D tomo- graphic slices
The choice of the display technique is generally determined by the
clinical application.
60. Volume Rendering
▪ Volume rendering is a technique that uses different types of
algorithms to preserve all 3DE information and project it, after
processing, onto a 2D plane for viewing.
▪ Volume-rendered 3DE data sets can be electronically segmented and
sectioned.
▪ To obtain ideal cut planes, the 3D data set can be manipulated,
cropped, and rotated.
▪ Volume rendering provides complex spatial relationships in a 3D
display that is particu- larly useful for evaluating valves and adjacent
anatomic structures.
61. From a transthoracic 3DE data set of the left ventricle (left), the LV endocardium can be traced (middle, top) to obtain the LV
volume throughout the cardiac cycle (right, top). As well, the LV endocardium can be divided according to the 17-segment
model (middle, top), and the time each segment requires to attain minimal volume in the cardiac cycle can be identified (right,
bottom).
62.
63. Surface Rendering
▪ Visualization technique that shows the surfaces of
structures or organs in a solid appearance.
▪ Select structure (LV, RV, Atria)
▪ Trace Manually or automated
▪ Construction and display (Wire frame or 3D)
▪ Mostly volume and surface rendering are combined to get
full details
64.
65.
66. The RV volume can be determined from 3D echocardiographic data sets by the method of disks (left). Other methods include
dynamic endocardial tracking with end-diastolic volumes presented by the mesh shell and end-systolic volumes presented by the
solid shell (middle). The RV endocardial shell can be segmented for regional analysis (right).
67. 2D Tomographic Slices
▪ The volumetric data set is sliced or cropped to
obtain multiple simultaneous 2D
▪ Multiple levels and unique cuts
▪ Different planes like orthogonal or parallel planes
▪ Uniformly spaced cuts
▪ Accurate assessment of dimensions of chambers,
valves or defect
▪ Simultaneous orthogonal slides in ONE cardiac
cycle
81. LimitationsAlthough RT3DTEE represents an important step in perioperative
imaging, significant imitations remain. First, while 3D zoom and live 3D are indeed real-
time modes, the acquisition of a 3D full volume as well as a 3D color full volumes are
based on automatic reconstruction from subvolumes and are therefore prone to
artifacts from arrhythmias, and ventilation – the socalled stitch artifacts. Second, as 3D
echo obeys the same physical laws as 2D, poor 2D image quality will likely translate in
similarly poor 3D image quality. Unlike the mitral valve, other structures in the far field
like the aortic and tricuspid valves are more difficult to visualize using current
technology.Third, direct measurements (e.g. caliper, trace) cannot be performed
directly in 3D images and require the use of time-consuming software. Fourth,
although the built-in software features quantitative assessment of the mitral valve and
left ventricle, it would benefit from a more user-friendly interface. Finally, as with most
new technology, RT3DTEE will prolong a comprehensiveTEE examination, especially
when quantitative techniques are employed. However, in the future and with further
improvements in technology, RT3DTEE may help to Fig 4: 3DTEE en-face view of a
mechanical bileaflet prosthesis in the mitral position with an Amplatzer occluding
device positioned to seal a paravalvular leak (arrow). Page 6 of 6 even expedite a
comprehensiveTEE examination by using a single 3D view of the mitral valve rather
than the five conventional 2D views.
82. • Live 3D: displays a pyramidal dataset with dimensions of approximately 50° x 30° that can be used to
display cardiac structures located in the near field. •.
83.
84. • FullVolume: that allows the inclusion of a larger cardiac volume.The wide angle data set
is compiled by merging four to seven narrower RT-3D pyramidal wedges obtained over
four to seven heartbeats. Imaging artifacts may be avoided in the anesthetized patient by
suspending ventilation and avoiding electrocautery use during acquisition of the full
volume sequence.Therefore, it is desirable to acquire full volume loops at the beginning of
the comprehensiveTEE-exam in the operating room prior to the start of surgery.A full
volume loop of the left ventricle is based on the 2D midesophageal four chamber view.
When selected, the full volume mode displays a biplane image with the four chamber view
and the (perpendicular plane) corresponding orthogonal image.The 3D-volume is
displayed as a 50% cropped volume mirroring the four chamber view.This is necessary
since the full volume image at the outset will not display intraventricular structures like
valves, papillary muscles etc. Resetting the crop plane however, allows the whole
pyramidal dataset to be displayed.The full volume can be further processed offline by
rotating and cropping to visualize specific intracardiac structures. Cropping can be
performed by either using one of six available cropping planes selected from a 3D cropping
box or by using a freely adjustable plane. Acquired full volumes can also be used for
volumetric quantification of the LV using available built-in software (QLAB, Philips Medical
Systems,Andover, MA).
85. • 3D Color FullVolume: Similar to the acquisition of a full
volume the wide angle data set is compiled by merging 7 to 14
narrower RT-3D pyramidal wedges and is similarly prone to
artifacts introduced by arrhythmias, movement, or
electrocautery. For this mode it is essential to place the area of
interest, for example, the regurgitant jet, in the center of the
sector.The remainder of the acquisition is identical to that
used for full volume acquisition. In the newer software release,
the color full volume may be acquired using 1, 2, 4 or 6
separate slices.Once again, one must balance the need for
optimal frame rates (more slices) with the tendency for stitch
artifacts.