Its important to recognise the myelination pattern in neonates and infants. This presentation talks about the myelination pattern and imaging of white matter diseases in children.
Its important to recognise the myelination pattern in neonates and infants. This presentation talks about the myelination pattern and imaging of white matter diseases in children.
Radiology Spotters collection by Dr Pradeep. Nice collection Radiology spotters mixed collection ppt made by or collected by Dr. Pradeep, this is a collection of confusing spotter and very important spotter commonly asked in exams, our references is radiopaedia, learning radiology and Aunt Minnie.. Thanks
MRI in evaluation of white matter diseases like multiple sclerosis, leukodystrophies, demyelination, dysmyelination, ADEM, leukoencephalopathies, van der knaap disease, ALD, MLD, Krabbes disease, Leighs disease, Vanishing white matter disease, Canavan disease, Alexander disease
Radiology Spotters collection by Dr Pradeep. Nice collection Radiology spotters mixed collection ppt made by or collected by Dr. Pradeep, this is a collection of confusing spotter and very important spotter commonly asked in exams, our references is radiopaedia, learning radiology and Aunt Minnie.. Thanks
MRI in evaluation of white matter diseases like multiple sclerosis, leukodystrophies, demyelination, dysmyelination, ADEM, leukoencephalopathies, van der knaap disease, ALD, MLD, Krabbes disease, Leighs disease, Vanishing white matter disease, Canavan disease, Alexander disease
This is a chapter from Grainger and Allison. I have Coolected all images from chapter 19 with caption in this presentation.
In my opinion it will be very benificial to have this in your android. ,
Dr. Anjana Thadhani's presentation at Tata Learning Disability Forum (TDLF), 2013.
The Forum for Learning Disabilities centred on the theme ‘Learning Disabilities – a more inclusive perspective’. The forum this year included in its purview three additional Learning Disabilities (LD), namely Specific Learning Disability (SpLD), Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD).
In line with the TATA Group’s corporate sustainability endeavors, TIS initiated the Tata Learning Disability Forum (TLDF) in 2006 to ensure that students with special education needs receive the required attention as well as to spread awareness about LD which had been receiving scant attention in India. Since then, via the TLDF platform, TIS has been successful in generating an increased level of awareness and enabling progress in remediation activities for students with LD.
هذا العرض هو عبارة عن ملخص لبحث عن انواع الصعوبات التعلمية , حيث فيه القيت الضوء انا ومجموعة من زملائي على صعوبة الديسليكسيا من كل النواحي,وذلك في احدى مقررات ماجستير التربية المختصة ,في كلية التربية الفصل الاول ,اضعه بين ايديكم على امل ان يقدم لكل من يهتم بالاطفال وبموضوع الصعوبات التعلمية الفائدة
This is a chapter from Grainger and Allison. I have Coolected all images from chapter 20 with caption in this presentation.
In my opinion it will be very benificial to have this in your android. ,
Enfermedad de Creutzfeldt Jakob - Actualización clínica. Dr. Ignacio Rueda Medina. Unidad de Demencias HGMC. Sesión del Servicio de Neurología del Hospital Mancha Centro del 12-12-2017.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Pediatric white matter disorders can be distinguished
into well-defined leukoencephalopathies, and undefined
leukoencephalopathies. The first category may be subdivided into:
(a) hypomyelinating disorders; (b) dysmyelinating disorders; (c)
leukodystrophies; (d) disorders related to cystic degeneration of
myelin; and (e) disorders secondary to axonal damage. The second
category, representing up to 50% of leukoencephalopathies in
childhood, requires a multidisciplinar approach in order to define
novel homogeneous subgroups of patients, possibly representing
‘‘new genetic disorders’’ (such as megalencephalic
leukoencepahlopathy with subcortical cysts and vanishing white
matter disease that have recently been identified). In the majority of
cases, pediatric white matter disorders are inherited diseases. An
integrated description of the clinical, neuroimaging and
pathophysiological features is crucial for categorizing myelin
disorders and better understanding their genetic basis. A review of
the genetic disorders affecting white matter in the pediatric age,
including some novel entities, is provided.
13. The disease has 3 Presentations
Late infantile (18-24 months)
Gait disturbance, hypotonia to hypertonia, regression,
involuntary movements, neuropathy, cherry red spot
Juvenile (4-10 years)
Bradykinesia, poor school performance, ataxia, movement
disorder, neuropathy, slower progression
Adult.
After puberty get personality and mental changes, cortical
and cerebellar regression to frank dementia in third to
fourth decade
14. Metachromatic leukodystrophy. (a) T2-weighted MR image demonstrates bilateral
confluent areas of high signal intensity in the periventricular white matter. Note
the classic sparing of the sub-cortical U fibers (arrowheads). (b) Contrast material–
enhanced MR image shows lack of enhancement in the demyelinated white
matter, a finding that is characteristic of metachromatic leukodystrophy.
15. Metachromatic leukodystrophy. (a) T2-weighted MR image shows numerous linear tubular
structures with low signal intensity in a radiating (“tigroid”) pattern within the demyelinated
deep white matter. (b) T2-weighted MR image shows a punctate (leopard skin) pat-tern in
the demyelinated centrum semiovale, a finding that suggests sparing of the white matter. (c)
On a contrast-enhanced T1-weighted MR image, the tigroid pattern seen in a appears as
numerous punctate foci of enhancement (arrows) within the demyelinated white matter,
which is unenhanced and has low signal intensity (leopard skin pattern).
16.
17.
18.
19.
20. Krabbe disease with abnormal signal within the thalami and capsular regions.
21.
22.
23.
24.
25.
26. Niemann–Pick disease.
Niemann–Pick disease : refers to a group of inherited severe metabolic disorders that allow
sphingomyelin to accumulate in lysosomes, which are organelles in animal cells. The severe
form is fatal in toddlerhood; people with milder forms may live into their teens or young
adulthood. This disease involves dysfunctional metabolism of sphingolipids, which are fats
found in cell membranes, so it is a kind of sphingolipidosis. Sphingolipidoses, in turn, are
included in the larger family of lysosomal storage diseases (LSDs).
Niemann-Pick disease adult onset with psychosis.
28. GM1 gangliosidoses.
The GM1 gangliosidoses are caused by a deficiency of beta-
galactosidase, with resulting abnormal storage of acidic lipid
materials in cells of the central and peripheral nervous systems,
but particularly in the nerve cells.
GM2 gangliosidoses.
The GM2 gangliosidoses are a group of related genetic
disorders that result from a deficiency of the enzyme
beta-hexosaminidase. This enzyme catalyzes the
biodegradation of fatty acid derivatives known as
gangliosides. The diseases are better known by their
individual names.
34. ALD in a 5-year-old boy. (a) T2-weighted MR image shows symmetric confluent demyelination
in the peritrigonal white matter and the corpus callosum. (b) On a T1-weighted MR image, the
peritrigonal lesions appear hypointense. (c) Gadolinium-enhanced T1-weighted MR image
reveals a characteristic enhancement pattern in the intermediate zone (arrows) representing
active demyelination and inflammation. (8) ALD involving the corpus callosum splenium. T2-
weighted MR image shows the corpus callosum splenium with diffuse high signal intensity
(arrows). No abnormality of the periventricular white matter is seen.
55. Canavan disease in a 6-month-old boy with macrocephaly. (a) T2-weighted MR image shows
extensive high-signal-intensity areas throughout the white matter, resulting in gyral
expansion and cortical thinning. Striking demyelination of the subcortical U fibers is also
noted. (b) T1-weighted MR image shows demyelinated white matter with low signal intensity.
(c) Photomicrograph (original magnification, 200; hematoxylin-eosin stain) shows ballooning
of the myelin sheaths of oligodendrocytes due to massive intramyelinic edema.
63. Pelizaeus-Merzbacher disease.
Xq22 mutation in proteolipid protein 1 (PLP1)
Onset in first few months of life with rotary
head movements, rotary nystagmus, & motor
delay Then ataxia, tremor, choreoathetosis,
spasticity.
Seizures.
Optic atrophy and ocular impairments
MRI: Reversal of gray-white signal due to
diffuse demyelination
66. PMD in a 7-month-old boy. T2-weighted MR image reveals almost no
myelination of the cerebral white matter. The sub-cortical white matter
is also involved, as are the internal and external capsules (arrow-heads).
69. Vanishing White Matter Disease.
Vanishing White Matter Disease (VWM) is inherited in an
autosomal recessive manner, meaning that it is a disease
that can run in the family. Symptoms generally appear in
young children who may have been appearing to develop
fairly normally. However, it has been shown recently that
it can begin at or shortly after birth, as well, or even in
adulthood. A striking feature of the disease is that the
symptoms get worse slowly for the most part, but there
are episodes of rapid deterioration that follow an
infection or head trauma. The patient may have a partial
recovery following these episodes, or the episode may
lead to coma and death.
78. A rare syndrome characterized mainly by childhood ataxia and reduced myelination
of the cerebral nerves. Motor and mental development in the first few years of life is
normal with progressive neurodegeneration occurring between 2 and 5 years of age.
Fever and trauma to the head can speed up disease progression.
Cerebellar hypomyelination syndrome.