Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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37. 1- AP radiograph of the ankle shows a tremendous amount of swelling of the lateral malleolus with the apex of the swelling
centered on the distal fibular physis. There is a small bony fragment near the physis as well thought to be from an avulsion
injury. Salter-Harris I Fracture.
2-A 20-year-old non-BME (bone marrow edema) osteitis condensans ilii (OCI) patient with intermittent lower back pain for 4
years. (a) Pelvis radiograph demonstrates classic bilateral triangle bone sclerosis beneath the auricular surface of iliac bone
without sacroiliac joint (SIJ) space or surface changes. Same slice of SIJ oblique axial T1-weighted image (b) and short tau
inversion recovery magnetic resonance image (c) show symmetric sclerosis of iliac subchondral bone as very dark signal
intensity in both sequences without BME. Note bilateral SIJ spaces and surfaces are normal.
3-There is lateral displacement of the lesser metatarsals with respect to the first metatarsal with widening of the space between
the 1st and 2nd metatarsal baHomolateral Lisfranc fracture dislocation. se, with an intra-articular fracture from the medial
margin of the base of the 2nd metatarsal.
4- Sagittal (Left, Middle) and coronal (Right) reformatted computed tomography (CT) images of the spinal column revealed
osteopenia, calcifications, and height loss of intervertebral discs associated with kyphoscoliosis. Alkaptonuria and ochronotic
spondyloarthropathy.
5- Axial T2 Flair WI MR. Several in corticosubcortical junction intra-axial hyperintense lesions (tubers sclerosis) are observed.
6- Chiari Malformation Type I: (Left) T2-weighted sagittal MRI; (Right) T2-weighted axial MRI. Note that in Chiari malformation
type I the brainstem and cerebellar tonsils descend below the foramen magnum. In this case, the cerebellar tonsils and caudal
brainstem descended 17 mm below the foramen magnum.
7- Inverted papilloma with secondary sinusitis. Enhancing mass in the left side nasal cavity with destruction of the bony nasal
septum, left lateral nasal wall, erosion of lamina papyracea and the base of skull along the anterior cranial fossa with
secondary sinusitis in the maxillary sinus, left frontal and the sphenoid sinus.
8-Paget disease.
9-Madlung deformity.
10- Membranous right choanal atresia
38. 11- Axial CT without contrast of the temporal bones shows the left internal auditory canal (right) is smoothly
expanded and much larger than the right internal auditory canal (left). This enlargement of the left internal auditory
canal corresponded to the location of an enhancing mass within it on an MRI of the brain performed with contrast
from an outside institution. The diagnosis was left acoustic neuroma.
12- Sagittal T1 MRI without contrast of the brain (above left) shows a large mass expanding the entire brainstem.
Axial T2 (above right) and axial FLAIR (below left) MRI show the mass to be somewhat heterogenous and the mass has
multiple foci of enhancement on the axial T1 MRI with contrast (below right). The diagnosis was brainstem glioma.
13- CXR AP and lateral (above) show a large right sided chest mass whose obtuse angles with the chest wall suggest it
is extrapleural in origin. Axial CT without contrast of the chest (below) shows the mass to be arising from a rib and to
be causing periosteal reaction. The diagnosis was Ewing sarcoma of the rib (Askin tumor).
14- CXR (above left) shows a mass in the left hemithorax. Coronal (above right), axial (below left) and sagittal (below
right) CT with contrast of the chest show a large mass of soft tissue and fat density in the anterior mediastinum that
compresses the left lung posteriorly and causes mediastinal shift to the right.
The diagnosis was mediastinal teratoma.
15- Coronal (above) and axial (below) CT with contrast of the abdomen shows multiple peripheral wedge-shaped
areas of low density in the upper and middle left kidney. The right kidney is noted to be significantly smaller in size
than the left kidney. The diagnosis was acute pyelonephritis of the left kidney and chronic pyelonephritis of the right
kidney.
16- Sagittal US of the pelvis (above left) shows an enlarged right ovary with multiple peripheral follicles. Axial CT with
contrast of the abdomen (above right) shows the right ovary to be enlarged with multiple peripheral follicles and to be
malpositioned in the midline of the pelvis while the coronal CT (below) shows the right ovary to be in a position in the
midline above the bladder. The diagnosis was ovarian torsion.
39. 17- Coronal (left) and axial (above right) CT with contrast of the abdomen show a large low density
faintly calcified mass arising from the right adrenal gland. Axial image of the pelvis in bone windows
(below) shows multiple lytic bone lesions throughout the iliac wings and sacrum. The diagnosis was
neuroblastoma with diffuse bone metastases.
18- AXR (above) shows an extremely distended stomach with peristaltic waves (caterpillar sign).
Sagittal (below left) and transverse (below right) US of the pylorus shows the pylorus muscle to be
thickened and elongated in length, measuring 3.9 mm thick and 20 mm in length. The diagnosis was
hypertrophic pyloric stenosis.
19- Axial CT with contrast of the abdomen (above left) shows a large, inhomogenous multifocal
mass on the right side of the abdomen that enhances less than the liver and that did not appear to
arise from the right adrenal gland or right kidney. Axial T2 (above right) and axial (below left) and
coronal (below right) T1 MRI with contrast of the abdomen show the mass arising from and
involving nearly the entire liver and encasing the portal veins. The diagnosis was hepatoblastoma.
20- Coronal (left) and axial (right) CT with contrast of the abdomen shows wall thickening and
mucosal hyperenhancement of the terminal ileum with separation of the bowel loops due to
mesenteric infiltration of fat and prominent vasa recta (comb sign). The diagnosis was Chron
disease.
40. 21- Radiograph of the lower extremities shows an absent right femur and a deformity
of the left femur. The diagnosis was bilateral proximal focal femoral deficiency.
22- Radiograph of the feet shows varus angulation of the left forefoot. There is a dysplastic
appearing medial cuneiform bone with associated widening at the first tarsal-metatarsal joint.
The diagnosis was club foot.
23- Axial (above), coronal (below left) and sagittal (below right) CT with contrast of the
abdomen show a round, avidly enhancing soft tissue mass arising from the subcutaneous
tissues to the left of midline. The diagnosis was fibromatosis.
24- AP radiograph of the pelvis shows delayed ossification of the femoral heads, with multiple
femoral head ossification centers present along with delayed ossification of the pubic bones.
The diagnosis was spondyloepiphyseal dysplasia.
25- AP radiograph of the spine (left) shows thoracic scoliosis convex left (levoscoliosis) with a
compensatory lumbar scoliosis convex right, thus this is an atypical scoliosis curve for
adolescent idiopathic scoliosis. Sagittal T1 MRI without contrast of the cervical spine (above
right) shows the tip of the cerebellar tonsils over 10 mm beneath the foramen magnum. Sagittal
and axial T2 MRI of the thoracic spine (below right) show a large syrinx in the center of the
thoracic spinal cord. The diagnosis was abnormal adolescent idiopathic scoliosis due to a Chiari
I malformation causing a syrinx of the spinal cord.
41. 26- There is complete osseous fusion of the lunate and triquetrum.
27- Hemangiolipoma - ischioanal fossa,
28- Pott puffy tumor with the formation of an epidural abscess. The
initial concern for a superior sagittal sinus thrombosis on the CTV
was thought to be secondary to compression/mass effect from
the adjacent epidural abscess.
29-Barium swallow reveals fixed narrowing of the esophagus at
the level of the aortic arch without mucosal abnormality. The
narrowing runs obliquely from the inferior left to the superior
right and involves the posterior aspect of the esophagus. This
is consistent with extrinsic compression by a retro-esophageal
aberrant right subclavian artery resulting in dysphagia lusoria.
42. 30- MRI features most consistent wit quadrigeminal cistern lipoma (incidental finding).
31- There is an aberrant left pulmonary artery arising from the right pulmonary artery
and coursing behind the trachea at the level of the carina and anterior to the thoracic
esophagus.
32- Robert's uterus is a rare form of Müllerian duct anomaly and a subtype of the
asymmetric septated uterus that has a blind hemicavity with unilateral hematometra
due to obstruction by the septum and contralateral uterine cavity connecting to the
cervix with normal external uterine fundus contour and may be associated with
ipsilateral hematosalpinx and or endometrioma.
33- CT features of a duodenal diverticulum arising from the medial aspect of second
part of duodenum compressing the distal CBD most consistent with Lemmel syndrome.
Lemmel syndrome is defined as obstructive jaundice caused by a periampullary duodenal
diverticulum compressing the intrapancreatic common bile duct with resultant bile duct
dilatation.
34- MRI features of a well-defined cortical lesion with a "bubbly appearance" on the T2
sequence, most consistent with dysembryoplastic neuroepithelial tumor (DNET).