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Management of Increased intracranial pressure in cerebellar strokeNeurology Residency
Brief presentation of medical and surgical treatment options for massive cerebellar stroke. Discussion between placement of an extraventricular drain or suboccipital decompressive craniectomy.
R. Loch Macdonald, M.D., Ph.D.
Community Neurosciences Institute
Fresno, California, USA
Angiographic vasospasm and more accurately, delayed cerebral ischemia, continue to contribute to morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). It is known that angiographic vasospasm is common after SAH, occurring in two-thirds of patients. Cerebral infarctions that developed days after the SAH have been attributed to angiographic vasospasm, occuring in about a third of patients, although this has always been controversial. Angiographic vasospasm theoretically can only damage the brain by restricting blood flow but there is no easy, accurate, widely available method to measure cerebral blood flow and this is not the measurement we need. Blood flow depends on metabolic demand so what we need to know to determine if angiographic vasospasm is causing ischemia is oxygen extraction fraction in the brain tissue supplied the the spastic artery. Without this measurement, the attribution of ischemia to vasospasm is subjective. Since angiographic vasospasm is essentially the only detectable delayed phenomenon after SAH, we focus on it and apply tremendous resources to preventing or reversing the vasospasm. Undoubtedly angiographic vasospasm can cause cerebral infarctions, but it has to be severe and flow limiting. But SAH is a complex disease. There are many other causes for cerebral infarctions after SAH, the most common being due to the aneurysm repair procedure. And a given degree of vasospasm may cause infarction in a volume-depleted patient with poor collateral blood supply but not in a patient without these things. There also are hypodense brain lesions after SAH that are due to intracerebral hemorrhages. There can be hypodensities in the brain directly under usually thick SAH where the brain dies. This observation in particular supports a role for cortical spreading depolarizations/ischemia as a cause of infarction after SAH. Other macromolecular processes that are hypothesized to cause brain damage after SAH include microthromboembolism, changes in the microcirculation, delayed brain cell apoptosis and capillary transit time heterogeneity. Determining the importance of these things is hindered by the lack of an easy way to detect them in patients. It is also known that poor grade patients, who presumably have more early brain injury and ischemia than good grade patients, are more prone to delayed cerebral ischemia, suggesting increased sensitivity to secondary insults of the already injured brain. We also assume delayed neurological deterioration when attributed to vasospasm or delayed cerebral ischemia, is purely due to ischemia. While knowledge about what happens pathophysiologically after SAH is increasing, management of delayed cerebral ischemia still focuses on detecting angiographic vasospasm and then augmenting the blood pressure to improve cerebral blood flow or dilating the spastic arteries with balloons or drugs.
In this talk , we discuss the assessment and evaluation for patients presenting for cosmetic upper and lower lid blepharoplasty along with surgical technique.
Optic Neuritis and OCT in Multiple Sclerosis neurophq8
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This was a presentation given in the Kuwait Oculoplastic and Orbit meeting and will discuss the clinical approach and the diagnostic challenges associated with orbital IgG-4 RD and the recent diagnostic criteria with therapeutic options.
Transient loss of vision is common clinical problem that ophthalmologists and neurologists can face. This presentation will highlight clinical approach and important causes with management.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
4. Initial Presentation
19 y/o AAF
Pressure in retro-orbital and frontal regions
bilaterally
Blurry vision
Lightheadedness
Symptoms worsen with any change in posture
5. Initial Presentation
PMH: Seizure disorder
POH: None
Medications: Topamax 50mg BID
Allergies: NKDA
SH: ½ ppd tobacco, No EtOH, or drug use
FH: NC
ROS: negative
6. Initial Presentation
VA sc: 20/20 OD 20/25 OS
Pupils: No RAPD
EOM: Full OU
TA: 12 OD 12 OS
SLE: WNL
11. Lumbar Puncture
Opening pressure of 45 cm H2O
Glucose WNL
WBC WNL
Protein WNL
12. Modified Dandy Criteria
(Smith et al. J Clin Neuro-ophthalmol 1985)
1. Signs and symptoms of increased ICP.
2. No localizing neurological signs (except uni/
bilateral VI nerve palsy)
3. No evidence of an intracranial mass lesion
( by CT )
4. Normal CSF composition
13. Criteria for Idiopathic Intracranial
Hypertension
Friedman et al. Neurology 2002
1) If symptoms and signs are present, they
should reflect only increased ICP.
2) Documented increased ICP in the lateral
decubitus position (> 250 cm/H2O).
3) Normal CSF composition.
4) No evidence of hydrocephalus, mass, structural
or vascular lesion on CT with contrast for
typical patients, and MRI/MRV for all others.
5) No other cause of increased ICP found.
15. Spinal Tap
Keep the patient’s head neutral and legs
passively extended after needle in place.
If the patient’s head is flexed and knees
drawn up Increased cephalic venous
pressure (Valsalva) compression of
Jugular vein and hpoventilation (CO2
retention) Increased CSF pressure.
An IIH patient needs only one spinal tap !
16. Is CT adequate ?
Can detect hydrocephalus and most intra-
cranial lesions.
Misses venous sinus thrombosis,
radiographic signs of meningeal
infiltration, and isodense tumors.
If only alternative (weight, availability),
order contrast enhanced CT.
17. MRI and MRV
Ideally for all patients.
For atypical patients : (children with
recent sinus/ear infection, fulminant
course, non-responders to treatment).
19. Papilledema ?
Blood vessels
not obscured
by NFL
Anamolous
trifurcation
Drusen
Drusen
http://library.med.utah.edu/NOVEL/Hoyt
20. Papilledema ?
Drusen
Vessels not
obscured by
NFL
http://library.med.utah.edu/NOVEL/Hoyt
21. Features of Anamolous discs
(Peseuopapilledema)
Psudopapilledema True Papilledema
Disc vessels obscured Disc margin vessels clear
Elevation of peripapillary Elevation confined to the
NFL disc
Small cupless disc Loss of cup late
Anamolous disc vessels Normal vessels
(tri-, quadrifurcation)
No hemorrhage or NFL hemorrhage, cotton
exudates wool spots, exudate
23. IIH Treatment
“ There is insufficient information to
generate evidence-based management
strategy for IIH. Of the Various treatments
available, there is inadequate information
regarding which are truly beneficial and
which are potentially harmful”.
Cochrane Review 2002
24. Idiopathic Intracranial Hypertension
Treatment Trial
Randomized clinical trial.
In patients with mild visual loss ( MD -2 to -5
db), is Diamox better than placebo ?
In patients with moderate visual loss (-5 to -14
db), is ONSF with Diamox better than Diamox
alone ?
All patients will be on low salt, fluid-restricted
diet.
25. Venous Sinus Stenting
Focal stenotic lesions in the lateral
sinuses.
Higgins et al.
Journal of Neurology
Neurosurgery and
Psychiatry 2004;75:621-625
26. Venous Stenting
Four patients underwent stenting had improved
headache (Owler et al. J Neurosurg 2003).
Direct retrograde cerebral venography (DRCV)
is more sensitive than MRV in detecting venous
thrombosis.
Manometry showed a pressure gradient with
raised proximal venous pressure.
27. Does venous stenting really work ?
King et al. showed that in IIH patients, a
pressure gradient across a venous stenotic
lesion can be eliminated by removal of
CSF through a cervical puncture .
More longitudinal data are needed to
evaluate the efficacy of venous stenting.
28. Which shunt is better ?
115 patients with IIH: 79 had LP and 36 had ventriculo-
atrial (VAT) or ventriculoperitoneal (VP) shunts.
Headache only and no visual deficit.
LP shunts had higher revision rate (RR=2.5) and
obstruction (RR=3.0).
LP shunt 86% vs VAT/VP 44% revision rate after 24
months.
Ventricular shunts can placed by stereo-tactic, MR-
guided system.
(McGirt et al. J Neurosug 101:627-632, 2004).
29. Case-Follow Up
Improvement on Diamox
Resolution of symptoms
Papilledema improved
Diamox tapered
Nine months later
Recurrence of symptoms
No imaging done
Diamox restarted
Two therapeutic lumbar punctures
30. Four Months Later
Altered Mental Status
Combative
Complaining of severe headache
Screaming, “I can’t see”
EMS called
Sedated and intubated in ED
Unable to attain VA
39. Treatment of VST
Treatment of underlying cause
Anticoagulation
Systemic Heparin
Coumadin (INR 2.0-3.0)
Direct endovascular thrombolysis
Urokinase
tPA
Rheolytic
Endovascular recanalization
40. Follow Up
Thirty day admission
Treated for APS
Anticoagulation (Heparin Coumadin)
High dose steroids
Plasmaphoresis
Discharged
Coumadin (INR 2.0-3.0)
Prednisone
No recurrence
Bare LP OU
41. Case
Two separate presentations of
Pseudotumor cerebri syndrome in one
patient.
Idiopathic Intracranial Hypertension
Venous Sinus Thrombosis
42. Summary
IIH should be diagnosed using specific criteria.
Pseudopapilledema should be ruled out.
MRI/MRV is the neuro-imaging of choice.
The treatment of IIH is medical and surgery is
reserved for progressive visual loss and/or
persistent headache.
Consider repeat imaging in atypical cases
( fulminant course, poor response to treatment,
focal neurologic signs).
Editor's Notes
The patient is a 19 y/o AAF who presented with pressure in retro-orbital and frontal regions bilaterally. She also reported blurry vision, wavy vertical lines in both eyes, and lightheadedness. All of her symptoms seemed to worsen with any change in posture.
Her PMH is significant for a seizure disorder for which she takes Topamax. Dr. Myers, could Topamax cause any of these symptoms?
On examination her Va was 20/20 and 20/25. She had no RAPD, her pressures were normal as was the rest of her anterior segment exam.
Her dilated exam was significant for bilateral swollen discs.
Here are her visual fields. Dr. Myers could you comment on these fields? Dr. Bilyk what further studies would you perform on this patient?
Here is her MRI. Dr. Flanders could you comment on these images?
Here is her MRV, Dr Flanders could you comment on these images?
Lumbar puncture was done. The opening pressure was elevated but CSF was otherwise normal. Dr. Savino what would your diagnosis be at this point? Dr. Savino, do you typically differentiate PTC from IIH?
The first line therapy for patients with IIH is weight loss. Greater that 6% weight loss is associated with resolution of papilledema. Dr. Savino, how long do you usually wait until starting medical therapy for patients? A recent study showed that 8/8 pts with IIH who had gastric bypass surgery had resolution of symptoms. Dr. Savino would you ever recommended this procedure for any of your patients? Diuretics, such as diamox are usually added next. Steroids are also used typically in the urgent setting prior to a procedure and in the PTC associated with SLE. Finally there are some interventional procedures. Dr. Savino, what dictates which procedure is recommended for these patients?
This patient was started on Diamox. She had a resolution of her symptoms and improvement of her papilledema. (Click) Nine months later she began having similar symptoms with headaches and visual disturbances. Dr. Savino, in patients with IIH and recurrent or persistent headache do you ever get further work up? (Click) The patient had no further work-up and was restarted on Diamox. (Click) She had minimal relief of symptoms on diamox and over the course of the next four months had two therapeutic lumbar punctures.
Four months later her mother returned home to find the patient hysterical. Pt was complaining of severe headache and said that she could not see. EMS was called and pt taken to ED at Cooper. She was sedated and intubated in the ED.
On hospital day #4 a MRI/MRV was done. Dr. Flanders could you comment on these images?
Here are the original images for comparison.
Here is the MRV. Dr. Flanders?
Again, the original images. Venous sinus thrombosis was diagnosed. Dr. Savino, to your knowledge have there been other cases of IIH progressing to VST? Dr. Bilyk, what further work up would you do on this patient?
The patient had a complicated hospital course. While her hypercoagulability work up was pending she developed renal failure, respiratory failure, liver failure, thrombocytopenia and anemia. (Click) She ultimately tested positive for Lupus Anticoagulant but did not fulfill criteria for SLE. Rest of hypercoagulability work-up was negative.
Pt was diagnosed with Venous Sinus Thrombosis secondary to Catastrophic Antiphospholipid Syndrome. Antiphospholipid syndrome is characterized by arterial and venous thrombosis, pregnancy loss, and thrombocytopenia in the presence of Antiphospholipid antibodies. One percent of patients with this syndrome have a fulminant course with high morbidity and mortality call Catastrophic Antiphospholipid Syndrome. This variant is characterized by involvement of 3 or more organs in less than one week.
Venous sinus thrombosis is the occlusion of one of the major dural venous sinuses. It causes increased intracranial pressure from venous hypertension leading to impaired CSF drainage. Many patients present with only symptoms of increased intracranial pressure. These patients present with PTC syndrome and are difficult to differentiate from IIH patients. Pts also can present with seizures and focal neurological deficits. These are usually the result of thrombosis extending to cortical veins and resulting in hemorrhagic venous infarcts.
Here I have compiled a list of conditions that have been reported to cause VST. The highlighted entities share an association with IIH. In one study of 38 IIH patients, 32% had coagulopathies, with antiphospholipid antibodies being the most common. Authors postulated that occult VST may be involved in the pathogenesis of IIH. Dr. Savino, given this information do you think that hypercoagulability work up should be done in all IIH patients? Lupus and oral contraceptive use is also more common in both. Interestingly 7% of pts with VST had recent lumbar puncture. Since IIH pts frequently have multiple LPs this may put them at increased risk for VST. IIH pts may have dehydration because of diuretics, and this may predispose them to VST as well.
Mainstay in treatment of VST is anticoagulation. Heparin followed by Coumadin is the typical regimen. Pts with severe symptoms in need of rapid intervention are treated with direct endovascular thrombolytics. There is also one case report of success with angioplasty and stenting. It is of course important to treat underlying cause if possible.
The patient was ultimately discharged after thirty days. Her main therapy consisted of treatment for CAPS with anticoagulation, high dose steroids and plasmaphoresis. The patient was discharged on Coumadin and prednisone. She has had no recurrences since discharge, however she remains bare LP in both eyes.
In summary this is a patient who presented on two separate occasions with PTC syndrome from two different causes. She demonstrates that it is difficult to distinguish the two entities clinically. This is a rare case but brings up the question, when do IIH patients require further work up?