1) Oxygen therapy equipment can be classified as either low-flow/variable-performance equipment or high-flow/fixed-performance equipment. Low-flow equipment includes nasal cannulas and masks, while high-flow includes anesthesia bags and venturi masks.
2) Key oxygen therapy devices include nasal cannulas, nasal masks, simple face masks, reservoir masks, venturi masks, nebulizers, oxygen hoods, and hyperbaric oxygen chambers. Each device has advantages and disadvantages for delivering different concentrations of oxygen under varying conditions.
3) Proper use and settings of oxygen therapy equipment, including sufficient gas flow, addressing leaks, and patient fit are important to ensure patients receive the targeted concentration of oxygen
oxygen is a medication. oxygen therapy must be known to all health professionals for optimum management of patient and optimum use of resourses. even more oxygen can cause oxygen toxicity and can harm the patient in many ways. There are various methods for giving oxygen,varieties of face masks, cylinders. also there is criteria when to give oxygen ,how to give oxygen,what are the benefits and mechanism of oxygen therapy.
Humidifiers in anaesthesia and critical careTuhin Mistry
Humidification of inhaled gases has been standard of care during mechanical ventilation in anaesthesia and intensive care. Active & Passive humidification devices have rapidly evolved. basic knowledge of the mechanisms of action of each of these devices, as well as their advantages and disadvantages, becomes a necessity for anaesthesiologists and intensivists.
oxygen is a medication. oxygen therapy must be known to all health professionals for optimum management of patient and optimum use of resourses. even more oxygen can cause oxygen toxicity and can harm the patient in many ways. There are various methods for giving oxygen,varieties of face masks, cylinders. also there is criteria when to give oxygen ,how to give oxygen,what are the benefits and mechanism of oxygen therapy.
Humidifiers in anaesthesia and critical careTuhin Mistry
Humidification of inhaled gases has been standard of care during mechanical ventilation in anaesthesia and intensive care. Active & Passive humidification devices have rapidly evolved. basic knowledge of the mechanisms of action of each of these devices, as well as their advantages and disadvantages, becomes a necessity for anaesthesiologists and intensivists.
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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2. Classifying Oxygen Therapy Equipment
Oxygen is given either:
1- Alone or
2-In a gas (mixed with air, helium, or nitric oxide)
Oxygen can be administered:
1- As a partial supplement to patients' tidal or
minute volume.
2- As the only source of the inspired volume.
3. Classification of oxygen therapy equipment
1- LOW-FLOW OR VARIABLE-PERFORMANCE EQUIPMENT
a) Oxygen (usually 100%) is supplied at a fixed
flow that is only a portion of inspired gas.
b) Such devices are usually intended for
patients with stable breathing patterns.
c) As ventilatory demands change, variable
amounts of room air will dilute the oxygen
flow.
4. 2- HIGH-FLOW OR FIXED-PERFORMANCE EQUIPMENT
a) Inspired gas at a preset FIO2 is supplied
continuously at high flow or by providing a
sufficiently large reservoir of premixed gas.
b) Ideally, the delivered FIO2 is not affected by
variations in ventilatory level or breathing
pattern.
5. 1-Variable-Performance Equipment
1-Nasal Cannulas
A) The nasal cannula is available as either:
a) a blind-ended soft plastic tube with an over-the-
ear head-elastic
b) or dual-flow with under-the-chin lariat
adjustment.
B) Sizing is available for adults, children, and infants.
C) Cannulas are connected to flowmeters with
small-bore tubing and may be used with a bubble
humidifier.
6. D) Advantages:
1- The nasal cannula can be rapidly and comfortably
placed on most patients.
2- Patients on long-term oxygen therapy most
commonly use a nasal cannula.
3- The appliance is usually well tolerated.
4- It allows speech and eating/drinking
7. Factors affecting the actual FIO2 delivered to
adults by nasal cannula:
E) The actual FIO2 delivered to adults with nasal
cannulas is determined by:
1- Oxygen flow
2- Nasopharyngeal volume
3- The patient's inspiratory flow (which depends
both on VT and inspiratory time).
8. Nasal cannula flow and FIO2
F) Nasal cannulas can be expected to provide
FIO2 up to 30–35% with normal breathing and
oxygen flows of 3–4 L/min.
G) FIO2 levels of 40–50% can be attained with
oxygen flows of greater than 10 L/min for short
periods.
9. Why nasal cannula flow > 5L/min is
poorly tolerated?
H) Usually flows greater than 5 L/min are poorly
tolerated because of:
1- The discomfort of gas jetting into the nasal
cavity.
2- Drying and crusting of the nasal mucosa.
14. 2- Nasal Mask
A) The nasal mask is a hybrid of the nasal
cannula and a face mask.
B) Nasal masks have been shown to provide
supplemental oxygen equivalent to the nasal
cannula under low-flow conditions for adult
patients.
15. Advantage
1- Patient comfort and compliance
2- Home use for obstructive sleep apnea (C-PAP and
Bi-PAP).
Disadvantages
2- Sores can develop around the external nares of
long-term nasal cannula use
17. 3- Nonreservoir Oxygen Mask
The "simple," or nonreservoir mask is a disposable
lightweight plastic device that covers both nose
and mouth.
The face seal is rarely free of "inboard" leaking;
therefore, patients receive a mixture of pure
oxygen and secondarily entrained room air.
18. Factors affecting oxygen/entrained air ratio during
face mask ventilation
This ratio varies depending on:
1- Size of leak
2- Oxygen flow
3- Breathing pattern
19. A minimum oxygen flow of approximately 5 L/min
is applied to the mask to avoid rebreathing and
excessive respiratory work.
Disadvantages:
1- Wearing the mask for long periods of time is
uncomfortable.
2- Speech is muffled.
3- Drinking and eating are difficult.
20. FIO2 and flow of non rebreathing
simple face masks
It is difficult to predict delivered FIO2 at specific
flows.
During normal breathing, it is reasonable to expect:
1- FIO2 of 0.3 with flows of 5 L/min
2- FIO2 of 0.6 with flows of 10 L/min
21. Indications
1- The non-reservoir mask is used for patients who
require higher levels of oxygen than nasal cannulas
but need oxygen therapy for short periods of time.
Examples include
1- Therapy in the post anesthesia care unit(PACU).
2- Emergency department.
22. Contraindications
It is not the device of choice for patients with
severe respiratory disease who are;
1- Profoundly hypoxemic.
2- Profoundly tachypneic.
3- Unable to protect their airway from aspiration.
25. 4- Reservoir Masks
Incorporating a gas reservoir is a logical
development to the simple mask.
Two types of reservoir mask are commonly used:
A) The partial rebreathing mask.
B) The nonrebreathing mask.
Mask reservoirs commonly hold approximately 600
mL or less.
26. The partial rebreathing mask
The term "partial rebreather" refers to "part" of
the patient's expired VT refilling the bag.
Usually that gas is largely dead space that should
not result in significant rebreathing of carbon
dioxide.
27. The nonrebreathing mask.
The nonrebreather uses the same basic system as
the partial rebreather but incorporates flap-type
valves between the bag and mask and on at least
one of the mask's exhalation ports.
Inboard leaking is common, and room air will enter
during brisk(high) inspiratory flows, even when the
bag contains gas.
28. Disadvantages of reservoir masks:
1- The lack of a good facial seal system.
2- A relatively small reservoir.
Which can affect (decrease)delivered oxygen
concentration.
The key factor to successful application of the
masks is to use sufficient flow of oxygen, so the
reservoir bag is at least partially full during
inspiration.
29. Partial rebreathing masks FIO2 and flow
Typical minimum flows of oxygen are 10–15 L/min.
Well-fitting partial rebreathing masks provide:
1- FIO2 from 0.35 to 0.60 with oxygen flows up to
10 L/min
2- FIO2 may approach 1.0 with inlet flows of 15
L/min or more and ideal breathing conditions.
30. Indications of reservoir masks:
Patients suspected of significant hypoxemia, with
relatively normal spontaneous minute ventilation.
Such as patients with;
1- Trauma.
2- Myocardial infarction.
3- Carbon monoxide poisoning.
35. 2- Fixed-Performance (High-Flow)
Equipment
1- Anesthesia Bag or Bag-Mask-Valve Systems
The basic design follows that of the nonrebreathing
reservoir mask.
A- Self-inflating bags (AMBU) consist of a football-
sized bladder, usually with an oxygen inlet reservoir.
B- Anesthesia bags are 1, 2, or 3L non–self-inflating
reservoirs with a tailpiece gas inlet.
36. • Masks are designed to provide a comfortable
leak-free seal for manual ventilation.
• The inspiratory/expiratory valve systems may
vary.
• The flow to the reservoir should be kept high so
that the bags do not deflate substantially.
37. • When using an anesthesia bag, operators may
frequently have to adjust the oxygen flow and
exhaust valve spring tension to respond to
changing breathing patterns or demands
38. • The most common system for disposable and
permanent self-inflating resuscitation bags
(AMBU bags) uses a unidirectional gas flow.
• There are limits to the ability of each system to
maintain its fixed-performance characteristics.
• Delivered FIO2 can equal or approach 1.0 with
either anesthesia or self-inflating bags.
39. • Spontaneously breathing patients are allowed
to breathe only the contents of the system if
the mask seal is tight and the reservoir is
adequately maintained.
• Operators must adjust gas flow to the bag to
accommodate for any changes in ventilation
demand; observation of patient and reservoir
provides that information.
40. • A primary concern for clinicians using mask-
bag systems is aspiration.
• Failure to maintain an adequate oxygen supply
in the reservoir and inlet flow is another
concern.
• The spring-loaded valve of anesthesia bags
must be adjusted properly to prevent
overdistention of the bag.
41. • Self-inflating bags do not look different when
oxygen flow to the unit is inadequate, and
they will entrain room air into the bag, thus
lowering the delivered FIO2.
46. 2- Air-Entrainment Venturi Masks
• The gas delivery system with air-entrainment masks
is somewhat different than with an oxygen reservoir.
The goal in venturi mask design is to:
1- Create an open system.
2- With high flow about the nose and mouth.
3- With a fixed FIO2.
• Oxygen is directed by small-bore tubing to a mixing
jet; the final oxygen concentration depends on the
ratio of air drawn in through entrainment ports.
47. • Despite the high-flow concept, FIO2 can vary up
to 6% per setting.
Indications of venturi mask:
1- Patients whose hypoxemia cannot be controlled
on lower FIO2 devices such as the nasal cannula.
48. Causes of increased FIO2 than expected during use
of venturi masks:
FIO2 can increase if the entrainment ports are
obstructed by:
1- The patient's hands.
2- Bed sheets.
3- Water condensate.
56. 3- Air-Entrainment Nebulizers
• Large-volume, high-output or "all-purpose"
nebulizers have been used in respiratory care for
many years to provide bland mist therapy with
some control of the FIO2.
• These units are commonly placed on patients
following extubation for their aerosol-producing
properties.
57. • Like the entrainment masks, nebulizers use a
pneumatic jet and an adjustable orifice to vary
entrained air for various FIO2 levels at fixed
setting points or are continuously adjustable
from 0.24 to 1.0.
58. • Nebulizer systems can be applied to the patient
with many different devices, including
tracheostomy, face tent, and T-piece adapter.
These appliances can all be attached via large-
bore tubing to the nebulizer.
62. 4- Oxygen Hoods
• Oxygen hoods cover only the head, allowing
access to the infant's lower body while still
permitting use of a standard incubator or
radiant warmer.
Indications
The hood is ideal for relatively short-term oxygen
therapy for newborns and inactive infants.
63. • Normally, oxygen and air are premixed by an
air–oxygen blending device and passed
through a heated humidifier.
• There is no attempt to completely seal the
system, as a constant flow of gas is needed to
remove carbon dioxide (minimum flow > 7
L/min).
• Hood inlet flows of 10–15 L/min are adequate
for a majority of patients.
65. Helium–Oxygen Therapy
• Helium–oxygen (Heliox) mixtures have a
number of medical applications.
• Helium is premixed with oxygen in several
standard blends.
66. The most popular mixtures of Helium–Oxygen are:
1- 80%/20%
2- 70%/30%
• They are available in large-sized compressed gas
cylinders.
• The colour code for Heliox cylinder is white and
brown.
• In anesthetic practice, pressures needed to
ventilate patients with small-diameter tracheal
tubes (TTs) can be substantially reduced (Halved)
when the (Heliox) 80%/20% mixture is used.
67. Indications of Helium–Oxygen Therapy
Temporary relief in patients with acute distress from
upper airway–obstructing lesions such as:
1- Subglottic edema.
2- Foreign bodies.
3- Tracheal tumors.
69. • Patients' WOB(work of breathing) can be
reduced when Heliox is delivered via the
mechanical ventilator (noninvasive or via an
artificial airway).
• Non-intubated patients commonly receive
heliox therapy via mask with reservoir bag.
70. Hyperbaric Oxygen
• Hyperbaric oxygen therapy uses a pressurized
chamber to expose the patient to oxygen
tensions exceeding ambient barometric
pressure (usually > 760 mm Hg).
• Around 3 bars hyperbaric oxygen is commonly
used.
71. indications of hyperbaric oxygen include:
1- Decompression sickness.
2- Gas embolism.
3- Gas gangrene.
4- Carbon monoxide poisoning.
5- Treatment of certain wounds e.g diabetic foot.