Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. It is defined as a progressive decrease in bone mass, resulting in fragile bones that are prone to breaking. Common fracture sites are the hips, spine, and wrists. Osteoporotic fractures can lead to severe pain, disability, and increased risk of mortality. Preventive measures include exercise, avoiding smoking and excessive alcohol, and considering hormone therapy.
Definition of Osteoporosis - Prevalence - Risk factors for Osteoporosis - Diagnosis of Osteoporosis - Clinical manifestations- Laboratory investigations - DEXA - T and Z score - Management of Osteoporosis - Prevention
Osteoporosis is a skeletal disorder in association with compromised bone strength predisposing individuals to an increased fracture risk.
Osteoporosis occurs when there is imbalance between resorption and formation of bone, if resorption is often quicker and formation is slower, or for both reasons. This presentation includes definition, classification, diagnosis, treatment prevention and complications associated with osteoporosis.Osteoporosis can be prevented by properly awarening people about the facts of it. If etiological factors are minimized then the condition can be well regulated. Lifestyle changes like advising physical activities, prohibiting addictions like tobacco, smoking, alcohol, proper diet which in rich in calcium, phosphorus, salt restriction, getting exposure to sunlight. Intrinsic factors including poor vision, musculoskeletal and neurological disease and medications, whereas extrinsic or environmental factors including trailing wires, loose carpets, and ill fitting footwear assessment should be done for reducing fall complication risks.if dietary intake of calcium cannot be achieved then calcium supplementation should be provided. Caffeine intake should be properly regulated since it plays role in calcium excretion. Weight-bearing aerobic and strengthening exercises can decrease the risk of falls and fractures by improving muscle strength, coordination, balance, and mobility.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
Definition of Osteoporosis - Prevalence - Risk factors for Osteoporosis - Diagnosis of Osteoporosis - Clinical manifestations- Laboratory investigations - DEXA - T and Z score - Management of Osteoporosis - Prevention
Osteoporosis is a skeletal disorder in association with compromised bone strength predisposing individuals to an increased fracture risk.
Osteoporosis occurs when there is imbalance between resorption and formation of bone, if resorption is often quicker and formation is slower, or for both reasons. This presentation includes definition, classification, diagnosis, treatment prevention and complications associated with osteoporosis.Osteoporosis can be prevented by properly awarening people about the facts of it. If etiological factors are minimized then the condition can be well regulated. Lifestyle changes like advising physical activities, prohibiting addictions like tobacco, smoking, alcohol, proper diet which in rich in calcium, phosphorus, salt restriction, getting exposure to sunlight. Intrinsic factors including poor vision, musculoskeletal and neurological disease and medications, whereas extrinsic or environmental factors including trailing wires, loose carpets, and ill fitting footwear assessment should be done for reducing fall complication risks.if dietary intake of calcium cannot be achieved then calcium supplementation should be provided. Caffeine intake should be properly regulated since it plays role in calcium excretion. Weight-bearing aerobic and strengthening exercises can decrease the risk of falls and fractures by improving muscle strength, coordination, balance, and mobility.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
Know everything about Osteoporosis- prevention and management.
Did You Know?
The incidence of hip fracture is 1 woman to 1 man in India
Know more such facts and useful information on prevention of Osteoporosis.
Osteoporosis: Classification, Causes, Symptoms, Treatment & Prevention
In this article, we’ll discuss what osteoporosis is, osteoporosis definition, osteoporosis types, osteoporosis causes, osteoporosis symptoms, osteoporosis medicine, osteoporosis treatment and osteoporosis prevention.
Osteoporosis:
Osteoporosis is a condition of low bone mass and decay of bone tissue prompting bone delicacy and conceivably breaking with numerous preventable and intrinsic danger factors. Osteoporosis influences bones and makes them more defenseless against sudden and unanticipated breaks and breakage. The term osteoporosis is derived from the Greek words osteon (bone) and poros (pore). For complete article, click on the given link, https://diseases8804.blogspot.com/2021/08/all-you-need-to-learn-about-osteoporosis.html
Oss pro (Asma Saleem product Manager Neutro Pharma)Asma Saleem
A bone mineral density (BMD) test measures the density of minerals (such as calcium) in your bones using a special X-ray or scan. Bone (BMD) is related to bone strength
Multiple atraumatic osteoporotic vertebral fractures: Unusual cause of pain i...Apollo Hospitals
Secondary osteoporosis may not be detected early, and thus the condition remains clinically silent until the patient presents with multiple atraumatic compression fractures. It is devastating for a young patient to develop multiple vertebral fractures in view of the associated morbidity and mortality. To decrease the risk of additional fractures and preserve the quality of life in these patients, interventions should be initiated early. Hence, it is important to consider multiple osteoporotic vertebral fractures as a complication in any patient on prolonged steroid therapy.
Everything you should know about Osteoporosis?
What is Osteoporosis?
Osteoporosis is a disorder of bones characterized by low bone density and a deterioration of bone micro- architecture that enhances bone fragility and increases the risk of fracture
Osteoporosis becomes a serious health threat for aging men & postmenopausal women by predisposing them to an increased risk of fracture
Do you know that?
Osteoporosis is responsible for >1.5 million vertebral and non-vertebral fractures per year
Spine, hip, and wrist fractures are most common.
Infertility is defined as the inability of a couple to conceive after at least one year of regular unprotected intercourse.
Male infertility refers to a male's inability to cause pregnancy in a fertile female.
IDD situation in our country has improved
A good number of thyroid disorder patients are either undiagnosed and or untreated
Thyroid disorder in pregnancy- Rate high
As a sound thyroid functioning status is crucial for growth, development in children; reproduction, psychological and general wellbeing in adults, we must be proactive in screening, diagnosing and treating our patients.
Over the past several years it has been proved that maternal thyroid disorder influence the outcome of mother and fetus, during and also after pregnancy. The most frequent thyroid disorder in pregnancy is maternal hypothyroidism. It is associated with fetal loss, placental abruptions, pre-eclampsia, preterm delivery and reduced intellectual function in the offspring.1 In pregnancy, overt hypothyroidism is seen in 0.2% cases2 and sub clinical hypothyroidism in 2.3% cases3. Fetal loss, fetal growth restriction, pre-eclampsia and preterm delivery are the usual complications of overt hyperthyroidism (low TSH and high T3, T4) seen in 2 of 1000 pregnancies whereas mild or sub clinical hyperthyroidism (suppressed TSH alone) is seen in
1.7% of pregnancies and not associated with adverse outcomes4. Autoimmune positive euthyroid pregnancy shows doubling of incidence of miscarriage and preterm delivery. Worldwide more than 20 million people develop neurological sequel due to intra uterine, iodine deprivation5. Other problems of thyroid disorders in pregnancy are post partum thyroiditis, thyroid nodules and cancer, hyper emesis gravidarum etc. Debates and disputes persist regarding several protocol and management plan in this specific spectrum of diseases.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. Burden of Osteoporosis
Dr Shahjada Selim
Assistant Professor
Department of Endocrinology
Bangabandhu Sheikh Mujib Medical University, Dhaka
Email: selimshahjada@gmail.com, info@shahjadaselim.com
2. Definition of Osteoporosis
World Health Organization (WHO), 1994
Osteoporosis is a
skeletal disorder
characterized by
compromised bone
strength predisposing
to an increased risk
of fracture.
4/30/2017 Burden Osteoporosis by Dr Selim 2
4. Normal bone vs. Osteoporotic bone
• The normal bone shows a pattern of
strong interconnected plates of bone.
• Much of this bone is lost in
Osteoporosis and the remaining bone
has a weaker rod-like structure &
some of the rods are completely
disconnected.
• These bits of disconnected bone may
be measured as bone mass but
contribute nothing to bone strength.
5. Normal has appearance of a honeycomb matrix
(left) .Under a microscope , osteoporotic bone
looks more porous.
6. • Osteoporosis is characterized by
progressive decrease in bony mass that
results in increased bone fragility and
higher fracture risk, which can be primary
or secondary.
Clinician's guide to prevention and treatment of osteoporosis.20104/30/2017 Burden Osteoporosis by Dr Selim 6
7. • Osteoporotic fracture account 0.83% of
global burden of non communicable
diseases.
• Patients may confuse osteoporosis with
degenerative conditions
• Acute pain in vertebral fracture usually
resolve in 4-6 weeks.
Clinician's guide to prevention and treatment of osteoporosis.20104/30/2017 Burden Osteoporosis by Dr Selim 7
8. Cont…
• Fracture spine typically by OP is
generally compression fracture or
wedge fracture.
• Fractures can anywhere in the spine,
rarely above the T7
• Wedge-shaped vertebra on back -
stooped posture called dowager’s
hump.
• Fractures of OP increases
dramatically with ageing, (4 “I”) and
Sarcopenia.
4/30/2017 Burden Osteoporosis by Dr Selim 8
9. Osteoporosis, despite being a common
metabolic bone disease, has attracted little
attention and even less action in many
developing countries.
There are several reasons for this state of
neglect.
4/30/2017 Burden Osteoporosis by Dr Selim 9
10. Definition by DXA scoring
T score Category
> -1 Normal
< -1 to > 2.5 Osteopenia
<-2.5 Osteoporosis
<-2.5 with
fragility fracture
Established/severe
osteoporosis
WHO Criteria
4/30/2017 Burden Osteoporosis by Dr Selim 10
11. Rosen, Endotext.com, Chap.11
Epidemiology
• 3,00,000 new cases per year
• Osteoporosis affects 65% of Indians aged 50 and
above. Of these, approximately 80% are women.
• 50% of women over age 50 will sustain a fracture
in their lifetime
• The condition is responsible for millions of
fractures annually, mostly involving the lumbar
vertebrae, hip, and wrist.
• Fragility fractures of ribs are also common in men.
12. Contd.
200 million women worldwide.
40% of women over 50 have osteopenia.
7% of women over 50 have osteoporosis.
Causes >8.9 million fracture worldwide
annually, resulting a osteoporotic fracture
every 3 second.
http://www.iofbonehealth.org,2012.
4/30/2017 Burden Osteoporosis by Dr Selim
12
17. Taiwan, Singapore, and Hong Kong-
400 to 500 per 100,000 women; similar to Caucasian
populations
Japan - > 200 - 300 per 100,000 women
Malaysia and Thailand- 200 - 250 hip fracture per
100,000 women
Korea and China- 100 hip fracture per 100,000 women;
increased over a short period
By 2050 more than 50% of all osteoporotic fracture
will occur in Asia
The Asian Audit 20094/30/2017 Burden Osteoporosis by Dr Selim 17
In Asian….
18. NIH/ORBD National Resource Center. October 2000.
Vertebral
46%
(700,000)
Wrist
16%
(250,000)
Hip
19%
(300,000)
Other
19%
(300,000)
• Distribution of Fractures
Clinical features & Consequences
18
19. • Non- Vertebral/spine fractures
Almost all - traumatic & easy to diagnose clinically
• Vertebral fractures
Only 1/3 diagnosed clinically.
Of clinically diagnosed vertebral fractures, only 14%
follow severe trauma whereas > 83% follow
moderate or no trauma.
Sudden onset of pain is an useful marker of fracture
Endocrine Metab Clin North Am 1998;27:289-301
J Bone Miner Res 1997;12:663-6754/30/2017 Burden Osteoporosis by Dr Selim 19
20. About 2/3 of the fractures causes no
symptoms. 1/3 of vertebral fractures, with
acute back pain
50% of women and 20% of men above 50 will
have an OP related fracture in their lifetime
85% of OP patients with low back pain is
considered the prevalent musculoskeletal
pain, particularly in elderly.
Endocrine Metab Clin North Am 1998;27:289-301
J Bone Miner Res 1997;12:663-6754/30/2017 Burden Osteoporosis by Dr Selim 20
31. COMPLICATIONS:-
• Fractures are most frequent and serious
complications of osteoporosis.
• Often occurs in spine and hips – bones that
directly support your weight.
• Hip fractures and wrist fractures from fall are
common.
• Compression fractures can cause severe pain
and require a long recovery
32. Consequence of Fracture
After the first hip fracture, 30% of patients will fracture
the second hip.
Nearly 20% of the women who develop a new
vertebral fracture will fracture again within a year.
5 year survival rate following a vertebral fracture is
equally worse as a Hip fracture.
It is clear that bone loss cannot be completely
reversed but fracture risk can be decreased by
intervention.
One year mortality following a hip fracture in men is
twice that of female
33. PREVENTION
Do exercise such as walking , running ,
skipping rope , jogging regularly.
Avoid smoking , it can reduce the level of
estrogen and increases bone loss.
Avoid excessive alcohol.
Avoid caffeine , which is very harmful.
Consider hormone therapy.
34. Thanks for your patience
THANKS
4/30/2017 Burden Osteoporosis by Dr Selim 34