This document summarizes ankylosing spondylitis (AS), a type of spondyloarthritis. It discusses the characteristics, pathogenesis, clinical features, diagnostic criteria, treatment options, and surgical management of AS. Key points include that AS is a seronegative inflammatory disease associated with HLA-B27 antigen that causes inflammation in the axial skeleton. Symptoms include back pain and stiffness that worsens with inactivity and improves with exercise. Treatment involves NSAIDs and TNF-alpha inhibitors. Surgical interventions may include total hip replacement or spinal osteotomies.
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
This is a short presentation on avascular necrosis of femoral head. This presentation gives brief description of causes of AVN, investigations and modes of treatment options available.
AVN TREATMENT IN HYDERABAD
Core decompression for AVN
Stem cell treatment for AVN
Surgery for AVN
Avascular necrosis treatment options
Hip replacement in hyderabad
Hip specialist in hyderabad
Hip surgery in hyderabad
Total hip replacement in hyderabad
cemented hip replacement
uncemented hip replacement in hyderabad
ceramic hip replacement
delta motion hip
ceramic on ceramic hip replacement
metal on poly hip replacement
affordable hip replacement in hyderabad
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
This is a short presentation on avascular necrosis of femoral head. This presentation gives brief description of causes of AVN, investigations and modes of treatment options available.
AVN TREATMENT IN HYDERABAD
Core decompression for AVN
Stem cell treatment for AVN
Surgery for AVN
Avascular necrosis treatment options
Hip replacement in hyderabad
Hip specialist in hyderabad
Hip surgery in hyderabad
Total hip replacement in hyderabad
cemented hip replacement
uncemented hip replacement in hyderabad
ceramic hip replacement
delta motion hip
ceramic on ceramic hip replacement
metal on poly hip replacement
affordable hip replacement in hyderabad
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Ankylosing spondylitis
1.
2. AS is a seronegative inflammatory disease of
unknown etiology characterized by inflammation in
the axial skeleton esp; SI joint, principally affecting
young males in the 3rd
decade.
Course of the disease is said to be one of the
relentless progression with periods of
exacerbation & remission.
3. Ankylos – bent or fused, spondylos – vetebrae.
Marie Strumple or Von Bechterew disease
It belongs to group of spondyloarthritis.
Share certain C/F & an association with HLA B-27
allele.
4. M:F 3:1
2nd
to 4th
decade
6 per 10,000 of G. population
Autosomal inheritance, with 70% penetrance in
males, 10% in females.
90% pts have HLA B- 27 antigen.
Increased incidence among relatives.
5. Located in the short arm of chromosome 6
One of the series of closely linked polymorphic
loci in that region.
Incidence in N. population – 8% in caucasians, 4%
in blacks.
Neither necessary nor sufficient to cause AS
Positive individuals tends to have early onset.
No correlation with severity.
6. Carriers of this gene have a 16% to 50%
increased risk of developing AS,
Virtually absent among the aboriginal populations
of Australia and South America.
Negative individuals doesn’t have family history.
Susceptibility to AS almost entirely determined by
genetic factor with HLA constituting about 1/3 of
genetic component.
7. autoimmune disorder
subsequent to a Klebsiella pneumoniae infection
in HLA-B27–positive individuals,
Molecular mimicry,
incidence of AS in patients with idiopathic bowel
disease is approximately 3.7%.
8. ENTHESOPATHY , Hall mark of AS.
combination of inflammation and bony destruction
at the site of tendon insertion
Ass with prominent edema of the adj bone marrow
& is often characterised by erosive lesions that
eventually undergoes ossification.
9. Distribution of lesion: in synovium, articular
capsular & ligamentous attachments to bones.
Articular lesions due to 2 primary mech, synovitis,
enthesitis
2 subsidary mech, enchondral & trauma.
In spine: early, there is inflammatory granulation
tissue at the jn of AF of disc cartilage with the
margin of V.B.
Outer AF is replaced by bone – bony osteophytes,
fusion of adj V.B.
11. Extra articular invoivement
Most C. anterior uveitis. [30%]
AR, Third degree heart block.
Subclinical pulm. Lesion, cardiac dysfn.
Cauda equina syn & slow progressive upper lobe
fibrosis in long standing cases.
Progression of the diseaseas monitered by Pt Ht,
chest expansion, scoebers test, occiput to wall
distance.
Jaw involvement- old pts.
Thorax involvement.
12. Loss of lumbar lordosis
Exaggerated kyphosis
Head & neck move forwards on the shoulder
Mister punch posture: rounded dorsal spine,
flattened chest & protrubent abdomen.
Wide bases stance.
13. I – phase: Isolated phases characterised by
attacks of pain & stiffness occuring in increasingly
frequent intervals, corresponding to pre-
ankylosing stage.
II- phase: continuous symptoms & constitutional
upset.
III- phase: declining disease activity & reduced
symptoms with episodic minor relapses.
14. Early stage of the disease with typical symptoms
od spondylitis in absence of definite radiological
changes in the SI jt.
Associated with systemic symptoms include
anorexia, Wt loss, fatique, low grade quotidion
fever.
16. ESR, CRP
HLA B-27
Raised globulin fraction
Alkaline phosphatase.
RA factor negative
Rise in CSF protein level
Urinary 17- ketosteroid levels increase,
17. ASCA IgA levels are significantly high in AS &
other SpA than in healthy controls & Pt with RA
I Serological marker ass. With SpA
Can be marker of radiological damage & more
severe course in A.S
18. Blurring of cortical margins of subchondral bone
sclerosis & erosion pseudowidening of jt
space fibrous & bony ankylosis
Shiny corner sign- vetebral squarring
Star sign- SI jt.
Rail road track lines – zygoapophyseal jts
Marginal syndesmophytes
Bambo spine
19. Bone scan
MRI – si jt in early stages, more sensitive &
specific
DEXA- reduced BMD
Falsely elevated reading related to spinal
ossification can be avoided by using lateral
projection of L3 vetebrae.
23. definitive diagnosis of AS;
presence of the disease for at least 4 weeks;
presence of refractory disease(defined by the
failure of two types of NSAIDs during a single 3-
month period);
failure of local corticosteroid injection into inflamed
sacroiliac joints;
failure of sulfasalazine in patients with peripheral
disease;
no medical contraindications to the initiation of
treatment.
24. Infliximab: anti TNF – alpha monoclonal Ab
5 mg /kg body wt repeated 2 wks later, again 6
wks later, then at every 8 wks interval.
Etanercept: 25 mg by S.C inj twice weekly
25. Bisphosphate Pamidronate at a dose of 60 mg
monthly IV
Thalidomide 200 mg / day [inhibit TNF]
Alpha emitting isotope 224 Ra at a dose of 1 MBq.
26. Thirty percent to 50% of patients with AS exhibit
involvement of the hips; of those, 90% present
bilaterally.
THR is the most common surgery done in AS.
Mobilising the hip by THR before spinal
osteotomy makes easier to determine desired
degree of correction in spine.
27. AS patients are more prone to anterior dislocation
when acetabular components are placed in their
normal position relative to the pelvis.
When positioning the acetabular component in a
patient with AS, one must account for the
relationship of the pelvis to the lumbar spine in the
sagittal plane in order to avoid an excessively
hyperextended hip once the patient resumes an
upright position.
28. GT – not to be osteotomised
Due to osteoporosis & extensive capsular &
pericapsular fibrosis during dislocation of the
hip, increased chance of fracture.
Osteotomy of the neck & head can be removed as
piecemeal.
Capsulectomy should be adequate.
Precautions to avoid postop dislocation.
29. The level of risk for heterotopic bone formation
after THA in patients with AS remains
controversial.
The proportion of AS patients with functional
ankylosis secondary to HO following THA is
likely substantially lower than previously
thought.
High-risk
patients with preoperative ankylosis, with
previous hip surgery, with previous infection,
and/or in whom a transtrochanteric approach to
the hip was used should be considered for HO
prophylaxis
30. To improve the erect position there by to balance
the effect of gravity
To increase the respiratory function
To increase the GI fn.
Smith Peterson O.
Confined to the laminae & articular facets.
Ideally done at L2 & L3 levels.
31. Surgical intervention also may be indicated for
management of deformity, pseudarthrosis,
fracture, and spondylodiscitis.