Osteoporosis is a significant problem worldwide that affects hundreds of millions of people, especially women. It is projected that over 50% of osteoporotic hip fractures will occur in Asia by 2050. Osteoporosis is caused by low bone density and weak, brittle bones that are prone to fractures from minor stresses or falls. It often presents with back pain or loss of height and can lead to fractures of the spine, hip, or wrist. Risk factors include age, family history, small body frame, hormone or medication use, lack of calcium or vitamin D, and alcoholism. Diagnosis involves bone mineral density tests and treatment focuses on lifestyle changes, calcium/vitamin D supplementation, medications,

3. Osteoporosis is estimated to affect 200 million women
worldwide - approximately one-tenth of women aged 60,
one-fifth of women aged 70, two-fifths of women aged 80
and two-thirds of women aged 90
(2007) WHO Technical Report, University of Sheffield, UK: 66
It is projected that more than about 50% of all osteoporotic
hip fractures will occur in Asia by the year 2050
(Osteoporosis Int 7:407.(1998)
Osteoporosis seems to be a significant problem due to major
nutritional issues as well as limited and underutilized
diagnostic facilities
Epidemiology, costs and burden of osteoporosis in Asia 2009.

4. • Osteoporosis means “Porous bones”
causes bones to become weak and brittle
so brittle that even mild stress like
bending over ,lifting a vacuum cleaner
or coughing can cause a fracture
• In most cases bones weak when low levels of calcium
phosphorus and other minerals in bones and result as low
bone density
• As a common result of osteoporosis is fracture of the spine,
hip or wrist
• Although it is often thought of as women ‘s disease.
Osteoporosis also effect many men

5. Symptoms
• Back pain which can be severe if fracture
collapsed vertebra
• Loss of height over time with an
accompanying stooped posture
• Fracture of wrist,vertebera ,hip and other
bones

6. • Normal bone has the appearance of
honey comb matrix (left).Under
microscope osteoporotic bone
(right) looks porous bone

7. Causes
• The strength of the bones depends on their size and
density; bone density depends on the amount of
calicum,phosphours and other minerals bones
contain
• When the bones contain fewer minerals than
normal, they're less strong and eventually lose their
internal supporting structure

8. Risk Factors
• Fractures from the osteoporosis are about twice more in
women then men. Risk in women at menopause at age 45 that
accelerate bone loss. Risk in men is greater than age 75 year
• The older the higher risk of osteoprosis,bones become weaker
as ages
• Osteoporosis runs in families. Parent or sibling with
osteoporosis puts at greater risk, especially if having a family
history of fracture
• Men or women who are exceptionally thin or have small
body frame have grater risk because they may have less bone
mass to draw from as they age
• The greater women’s lifetime exposure to estrogen, the lower
higher risk of osteoporosis

9. • Women and men with anorexia ,nervosa and
bulimia are at Higher risk of bone density in
their lower backs and hips
• Long term use like prednisone, cortisons,
prednisolone and dexamethasone damaging to
bone
• Too much thyroid hormone can cause bone loss
• Postmenopausal women who have breast cancer
are at increased risk of osteoporosis especially
treated with chemotherapy or aromatase
inhibitor such as anastrazole and letrozole which
suppress estrogen

10. • A life long lack of calcium plays major role in the
development of osteoporosis
• Stomach surgery (gastrectomy) can affect the
body’s ability to absorb calcium
• Caffeine may interfere calcium absorption and its
diuretic effect may increase the bone loss
• People who experience serious depression have
increased rates of bone loss
• For men alcoholism is the leading risk factor of
osteoporosis. Excess consumption of alcohol
reduces bone formation and interfere with the
body’s ability to absorb calcium

11. National osteoporosis foundation
guideline
• Counsel on the risk of osteoporosis and related
fractures
• Performed BMD Test for all postmenopausal
women with fractures
• Recommended BMD for:
 Postmenopausal women <65 years with one or
more risk factors
 All women >65 years

12. Treatment and Diagnosis
• Osteopenia refers to the mild bone loss that isn’t
sever enough to be called osteoprosis,but that
increase risk of osteoporosis
• The best screening test is dual energy
absorptiometry(DEXA) measure the density of
bones in the spine, hip and wrist and it’s used to
accurately following changes in the bones over time
• Ultrasound
• Quantitate CT scanning

13. Estrogen and Bone Protection
• Estrogen is essential for healthy bone and that when
the production of estrogen
is reduced, as occurs normally
in Postmenopausal women
and pathogenically after
exposure to the radiation or
chemotherapeutic drugs ,
bones become brittle
and break easily

16. Ossein Mineral Complex Benefits
• OHC had a greater anabolic effect on bone than calcium
carbonate
Clin Drug Investig. 2011 Dec 1;31(12):817-24
• OHC is significantly more effective in preventing bone
loss than CC.
Menopause.2009 Sep-Oct;16(5):984-91
• Continuous administration of OHC prevents bone loss
in postmenopausal women, suggesting that this drug
may be useful in the management of postmenopausal
bone loss.
J Reprod Med. 1999 Jul;44(7):601-5

17. • MCHC not only cures but also prevents the
occurrence of osteoporosis
• It also reduces pregnancy snags & helps in
rermineralisation of bone during lactation
& in the normal course of life.
• It stimulates fracture healing.
• For rapid growth of children.
• It contains proteins, which help in
sterilization body temperature and also
help in physical growth & tissue repair.
Uses For MCHC