Oxygen therapy provides adequate oxygen in the blood while decreasing work of breathing and stress on the heart. It can be delivered via nasal cannula, masks, catheters, head boxes, tracheostomy collars, or through an endotracheal tube connected to a mechanical ventilator. Indications include hypoxemia, respiratory distress, heart conditions, and more. Nurses must monitor vital signs and comfort, ensure proper humidification and flow rates, and watch for side effects like oxygen toxicity when providing oxygen therapy.