HAI are a significant cause of increased morbidity and mortality in hospitalized patients. In addition, HAI lead to prolonged hospital stay, are inconvenient for the patients, and constitute huge economic burden on health care system. Studies have shown that HAI prevalence varies from 3.8% to 19.6% depending on the population surveyed with a pooled global prevalence of 10.1%.
HAI are a significant cause of increased morbidity and mortality in hospitalized patients. In addition, HAI lead to prolonged hospital stay, are inconvenient for the patients, and constitute huge economic burden on health care system. Studies have shown that HAI prevalence varies from 3.8% to 19.6% depending on the population surveyed with a pooled global prevalence of 10.1%.
Pathogenic microorganisms proliferate and invade bodily tissue, causing tissue harm and disease.
The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites those are not normally present within the body.
An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent.
An infection may remain localized, or it may spread through the blood or lymphatic vessels to become systemic (body wide).
Microorganisms that live naturally in the body are not considered infections.
For example, bacteria that normally live within the mouth and intestine are not infections.
Infection prevention policies and practices are used in hospitals and other health care facilities to reduce the spread of infections.
nosocomial infection are those healthcare associated infection which a patient can get during hospitalization . a majority of these infections are preventable . as these infections pose a very delitirious affect on the patient recovery and also increases the financial burden. each and every paramedical and medical professional is expected to be aware about prevention and control of nosocomial infection.
Hospital acquired infections: The different common sources of infection, their routes of spread and the growing antimicrobial resistance. Also includes a discussion on hospital Infection prevention and control guidelines and the universal and standard precautions.
Pathogenic microorganisms proliferate and invade bodily tissue, causing tissue harm and disease.
The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites those are not normally present within the body.
An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent.
An infection may remain localized, or it may spread through the blood or lymphatic vessels to become systemic (body wide).
Microorganisms that live naturally in the body are not considered infections.
For example, bacteria that normally live within the mouth and intestine are not infections.
Infection prevention policies and practices are used in hospitals and other health care facilities to reduce the spread of infections.
nosocomial infection are those healthcare associated infection which a patient can get during hospitalization . a majority of these infections are preventable . as these infections pose a very delitirious affect on the patient recovery and also increases the financial burden. each and every paramedical and medical professional is expected to be aware about prevention and control of nosocomial infection.
Hospital acquired infections: The different common sources of infection, their routes of spread and the growing antimicrobial resistance. Also includes a discussion on hospital Infection prevention and control guidelines and the universal and standard precautions.
Nosocomial Infections by Mohammad MufarrehMMufarreh
Reviews the definition, risk factors, types, sources, causes, and modes of transmission of healthcare-associated infections and the preventive measures that can be applied to minimize the risks.
Hospital Aquired Infection also called Nosocomial infection.This type of infection is common infection of the world by the contaminated environment of hospital.I hope this slides atleast give a basic level of knowledge for infection.
ABSTRACT
Nosocomial infections are infections acquired in hospital or healthcare service unit that first appear 48 hours or more after hospital admission or within 30 days after discharge following in-patient care. The main routes of transmission of nosocomial infections are contact, airborne, common vehicle and vector borne. Common infections are urinary tract infections (UTI), surgical and soft tissue infections, gastroenteritis, meningitis and respiratory infections. The agents that are usually involved in hospital acquired infections are Streptococcus sp., Acinetobacter sp., Enterococci, Pseudomonas aeruginosa, Coagulase negative Staphylococci, Staphylococcus aureus, Bacillus cereus, Legionella and Enterobacteriaceae family members including Proteus mirablis, Klebsiella pneumonia, Escherichia coli, Serratia marcescens. Out of these Enterococci, P. aeruginosa, S. aureus and E. coli have a major role. Various infection control programmes and organizations help to lower the risk of an infection during and after the period of hospitalization.
Key-words: Urinary tract infections, Hospital Acquired Infections, Route of Transmission, Epidemiology, Prevention and Control
Module 5 Case Assignment Pertussis (Whooping Cough)TasksPart .docxadelaidefarmer322
Module 5 Case Assignment:
Pertussis (Whooping Cough)
Tasks
Part A: In one page maximum
Briefly describe the disease: Pertussis in terms of its infectivity, pathogenicity, and virulence.
Identify any reservoir(s), and mode(s) of transmission
Part B: (1-2 pages)
Weighing the benefits and the risks, take a clear position on whether you feel vaccination programs for Pertussis (whooping cough) should be expanded in your current community. Explain factors that went into your decision.
HELPING REFERENCES
U.S. Food & Drug Administration, Center for Food Safety & Applied Nutrition (n.d.) Bad Bug Book. Retrieved February 21, 2013 from
http://www.fda.gov/Food/FoodSafety/FoodborneIllness/FoodborneIllnessFoodbornePathogensNaturalToxins/BadBugBook/default.htm
FAO. Epidemiology: some basic concepts and definitions. Retrieved February 21, 2013 from
http://www.fao.org/wairdocs/ILRI/x5436E/x5436e04.htm
Centers for Disease Control and Prevention (2004). How to Investigate an Outbreak. Retrieved February 21, 2013 from
http://www.cdc.gov/excite/classroom/outbreak/steps.htm
Aschengrau A, Seage GR (2003). Chapter 6: Overview of Epidemiologic Study Designs. Essentials of Epidemiology in Public Health, Boston: Jones & Bartlett Publishers. Retrieved February 21, 2013 at:
http://publichealth.jbpub.com/aschengrau/Aschengrau06.pdf
Cosio G (2005). Epidemiological Overview of Tuberculosis [Presentation]. Retrieved February 21, 2013 from
www.paho.org/cdmedia/dpccd01/Presentations/Day1/EPIDEMIOLOGICAL%20OVERVIEW%20OF%20TUBERCULOSIS%202.ppt
Optional Readings
Long SG, DuPont HL, Gaul L, Arafat RR, Selwyn BJ, Rogers J, et al. (2007). Pulsed-field gel electrophoresis for
Salmonella
infection surveillance, Texas, USA. Emerg Infect Dis [serial on the Internet]. Retrieved fro
http://www.cdc.gov/EID/content/16/6/983.htm
READ:
Variations in Severity of Illness
The severity of an illness may be measured by the case fatality rate or the proportion of surviving patients with complications. The
case fatality rate
is defined as the number of deaths from a particular disease divided by the number of clinically apparent cases of that disease.
An infectious disease may have a wide variety of clinical symptoms, ranging from no symptoms to severe clinical illness or death. Diseases such as tuberculosis have a high proportion of asymptomatic individuals (low pathogenicity), while diseases such as measles have a high proportion of symptomatic infections and a small percent of severe or fatal illness. Diseases such as the African hemorrhagic fevers caused by Marburg and Ebola virus are very severe and usually fatal. For diseases with low pathogenicity, only a small fraction of cases are often diagnosed and reported. Control measures should be directed toward all infections capable of being transmitted to others, not just the symptomatic cases.
From a public health perspective, diseases of high incidence and lesser severity may be considered a more serious problem becaus.
Microbe-Human Interactions: Infection and DiseaseMELVIN FAILAGAO
Chapter 12 Microbe-Human Interactions: Infection and Disease
subtopics:
1. The progress of an infection
2. Epidemiology: The study of disease in Populations
3. Non specific host defenses
4. Defense mechanisms of the host in perspective
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
Nosocomial infection
1. Nosocomial infection
Nosocomial infection
Classification and external resources
Contaminated surfaces increase cross-transmission
ICD-10 Y95
Look up nosocomial in Wiktionary, the free dictionary.
A nosocomial infection (nos-oh-koh-mi-al), also known as a hospital-acquired infection or
HAI, is an infection whose development is favoured by a hospital environment, such as one
acquired by a patient during a hospital visit or one developing among hospital staff. Such
infections include fungal and bacterial infections and are aggravated by the reduced resistance
of individual patients.[1]
In the United States, the Centers for Disease Control and Prevention estimate that roughly 1.7
million hospital-associated infections, from all types of microorganisms, including bacteria,
combined, cause or contribute to 99,000 deaths each year.[2] In Europe, where hospital
surveys have been conducted, the category of Gram-negative infections are estimated to
account for two-thirds of the 25,000 deaths each year. Nosocomial infections can cause severe
pneumonia and infections of the urinary tract, bloodstream and other parts of the body. Many
types are difficult to attack with antibiotics, and antibiotic resistance is spreading to Gram-
negative bacteria that can infect people outside the hospital.[2]
Known nosocomial infections
Ventilator associated pneumonia (VAP)
Staphylococcus aureus
Methicillin resistant Staphylococcus aureus (MRSA)
2. Candida albicans
Pseudomonas aeruginosa
Acinetobacter baumannii
Stenotrophomonas maltophilia
Clostridium difficile
Tuberculosis
Urinary tract infection
Hospital-acquired pneumonia (HAP)
Gastroenteritis
Vancomycin-resistant Enterococcus (VRE)
Legionnaires' disease
Epidemiology
This paragraph needs additional citations for verification. Please help improve
this article by adding citations to reliable sources. Unsourced material may be
challenged and removed. (January 2012)
Nosocomial infections are commonly transmitted when hospital officials become complacent
and personnel do not practice correct hygiene regularly. Also, increased use of outpatient
treatment means that people who are hospitalized are more ill[clarification needed] and have more
weakened immune systems[clarification needed] than may have been true in the past. Moreover,
some medical procedures bypass the body's natural protective barriers. Since medical staff
move from patient to patient, the staff themselves serve as a means for spreading pathogens.
Essentially, the staff act as vectors.
Categories and treatment
Among the categories of bacteria most known to infect patients are the category MRSA,
Gram-positive bacteria and Helicobacter, which is Gram-negative. While there are antibiotic
drugs that can treat diseases caused by Gram-positive MRSA, there are currently few
effective drugs for Acinetobacter. However, Acinetobacter germs are evolving and becoming
immune to existing antibiotics. "In many respects it‟s far worse than MRSA," said a specialist
at Case Western Reserve University.[2]
Another growing disease, especially prevalent in New York City hospitals, is the drug-
resistant Gram-negative germ, Klebsiella pneumoniae. An estimated more than 20 percent of
the Klebsiella infections in Brooklyn hospitals "are now resistant to virtually all modern
antibiotics. And those supergerms are now spreading worldwide."[2]
The bacteria, classified as Gram-negative because of their reaction to the Gram stain test, can
cause severe pneumonia and infections of the urinary tract, bloodstream, and other parts of the
body. Their cell structures make them more difficult to attack with antibiotics than Gram-
positive organisms like MRSA. In some cases, antibiotic resistance is spreading to Gram-
negative bacteria that can infect people outside the hospital. "For Gram-positives we need
better drugs; for Gram-negatives we need any drugs," said Dr. Brad Spellberg, an infectious-
disease specialist at Harbor-UCLA Medical Center, and the author of Rising Plague, a book
about drug-resistant pathogens.[2]
3. One-third of nosocomial infections are considered preventable. The CDC estimates 2 million
people in the United States are infected annually by hospital-acquired infections, resulting in
20,000 deaths.[3] The most common nosocomial infections are of the urinary tract, surgical
site and various pneumonias.[4]
Country estimates
The methods used differ from country to country (definitions used, type of nosocomial
infections covered, health units surveyed, inclusion or exclusion of imported infections, etc.),
so that international comparisons of nosocomial infection rates should be made with the
utmost care.
United States: The Centers for Disease Control and Prevention (CDC) estimates that roughly
1.7 million hospital-associated infections, from all types of bacteria combined, cause or
contribute to 99,000 deaths each year.[2] Other estimates indicate that 10%, or 2 million,
patients a year become infected, with the annual cost ranging from $4.5 billion to $11 billion.
In the USA the most frequent type of infection hospitalwide is urinary tract infection (36%),
followed by surgical site infection (20%), bloodstream infection (BSI), and pneumonia (both
11%).[2]
France: estimates ranged from 6.7% in 1990 to 7.4% (patients may have several
infections).[5] At national level, prevalence among patients in health care facilities was 6.7%
in 1996,[6] 5.9% in 2001[7] and 5.0% in 2006.[8] The rates for nosocomial infections were 7.6%
in 1996, 6.4% in 2001 and 5.4% in 2006.
In 2006, the most common infection sites were urinary tract infections (30,3%), pneumopathy
(14,7%), infections of surgery site (14,2%). infections of the skin and mucous membrane
(10,2%), other respiratory infections (6,8%) and bacterial infections / blood poisoning
(6,4%).[9] The rates among adult patients in intensive care were 13,5% in 2004, 14,6% in
2005, 14,1% in 2006 and 14.4% in 2007.[10]
It has also been estimated that nosocomial infections make patients stay in the hospital 4-5
additional days. Around 2004-2005, about 9,000 people died each year with a nosocomial
infection, of which about 4,200 would have survived without this infection.[11]
Italy: since 2000, estimates show that about 6.7% infection rate, i.e. between 450,000 and
700,000 patients, which caused between 4,500 and 7,000 deaths.[12] A survey in Lombardy
gave a rate of 4.9% of patients in 2000.[13]
United Kingdom: estimates of 10% infection rate,[14] with 8.2% estimated in 2006.[15]
Switzerland: estimates range between 2 and 14%.[16] A national survey gave a rate of 7.2% in
2004.[17]
Finland: estimated at 8.5% of patients in 2005[18]
Transmission
4. The drug-resistant Gram-negative germs for the most part threaten only hospitalized patients
whose immune systems are weak. The germs can survive for a long time on surfaces in the
hospital and enter the body through wounds, catheters, and ventilators.[2]
Main routes of transmission
Route Description
Contact the most important and frequent mode of transmission of nosocomial
transmission infections.
occurs when droplets are generated from the source person mainly during
coughing, sneezing, and talking, and during the performance of certain
Droplet
procedures such as bronchoscopy. Transmission occurs when droplets
transmission
containing germs from the infected person are propelled a short distance
through the air and deposited on the host's body.
occurs by dissemination of either airborne droplet nuclei (small-particle
residue {5 µm or smaller in size} of evaporated droplets containing
microorganisms that remain suspended in the air for long periods of time) or
dust particles containing the infectious agent. Microorganisms carried in this
Airborne manner can be dispersed widely by air currents and may become inhaled by a
transmission susceptible host within the same room or over a longer distance from the
source patient, depending on environmental factors; therefore, special air
handling and ventilation are required to prevent airborne transmission.
Microorganisms transmitted by airborne transmission include Legionella,
Mycobacterium tuberculosis and the rubeola and varicella viruses.
Common
applies to microorganisms transmitted to the host by contaminated items
vehicle
such as food, water, medications, devices, and equipment.
transmission
Vector borne occurs when vectors such as mosquitoes, flies, rats, and other vermin
transmission transmit microorganisms.
Contact transmission is divided into two subgroups: direct-contact transmission and indirect-
contact transmission.
Routes of contact transmission
Route Description
involves a direct body surface-to-body surface contact and physical transfer
of microorganisms between a susceptible host and an infected or colonized
person, such as occurs when a person turns a patient, gives a patient a bath, or
Direct-contact
performs other patient-care activities that require direct personal contact.
transmission
Direct-contact transmission also can occur between two patients, with one
serving as the source of the infectious microorganisms and the other as a
susceptible host.
involves contact of a susceptible host with a contaminated intermediate
object, usually inanimate, such as contaminated instruments, needles, or
Indirect-contact dressings, or contaminated gloves that are not changed between patients. In
transmission addition, the improper use of saline flush syringes, vials, and bags has been
implicated in disease transmission in the US, even when healthcare workers
had access to gloves, disposable needles, intravenous devices, and flushes.[19]
5. Risk factors
Factors predisposing a patient to infection can broadly be divided into three areas:
People in hospitals are usually already in a poor state of health, impairing their defense
against bacteria – advanced age or premature birth along with immunodeficiency (due to
drugs, illness, or irradiation) present a general risk, while other diseases can present
specific risks - for instance, chronic obstructive pulmonary disease can increase chances
of respiratory tract infection.
Invasive devices, for instance intubation tubes, catheters, surgical drains, and
tracheostomy tubes all bypass the body‟s natural lines of defence against pathogens and
provide an easy route for infection. Patients already colonised on admission are instantly
put at greater risk when they undergo an invasive procedure.
A patient‟s treatment itself can leave them vulnerable to infection – immunosuppression
and antacid treatment undermine the body‟s defences, while antimicrobial therapy
(removing competitive flora and only leaving resistant organisms) and recurrent blood
transfusions have also been identified as risk factors.
Prevention
Hospitals have sanitation protocols regarding uniforms, equipment sterilization, washing, and
other preventative measures. Thorough hand washing and/or use of alcohol rubs by all
medical personnel before and after each patient contact is one of the most effective ways to
combat nosocomial infections.[20] More careful use of antimicrobial agents, such as
antibiotics, is also considered vital.[21]
Despite sanitation protocol, patients cannot be entirely isolated from infectious agents.
Furthermore, patients are often prescribed antibiotics and other antimicrobial drugs to help
treat illness; this may increase the selection pressure for the emergence of resistant strains.
Sterilization
Sterilization goes further than just sanitizing. Sterilizing kills all microorganisms on
equipment and surfaces through exposure to chemicals, ionizing radiation, dry heat, or steam
under pressure.
Isolation
Isolation precautions are designed to prevent transmission of microorganisms by common
routes in hospitals. Because agent and host factors are more difficult to control, interruption of
transfer of microorganisms is directed primarily at transmission.
Handwashing and gloving
Handwashing frequently is called the single most important measure to reduce the risks of
transmitting skin microorganisms from one person to another or from one site to another on
the same patient. Washing hands as promptly and thoroughly as possible between patient
contacts and after contact with blood, body fluids, secretions, excretions, and equipment or
articles contaminated by them is an important component of infection control and isolation
6. precautions. The spread of nosocomial infections, among immunocompromised patients is
connected with Health Care Workers hand contamination in almost 40% of cases and it is a
real challenging problem in the modern hospitals. The best way for Health Care Workers to
overcome this problem is acting right hand hygiene procedures, this is why the WHO
launched in 2005 the GLOBAL Patient Safety Challenge.[22] Two categories of micro
organisms can be present on Health Care Workers hands: transient flora and resident flora.
The first one is represented by the micro organisms taken by Health Care Workers from the
environment, and the bacteria in it are capable of surviving on the human skin and sometimes
to grow. The second group on the other hand, is represented by the permanent micro
organisms that lived on the skin surface (on the stratum corneum or immediately under it).
They are capable of surviving on the human skin and to grow freely on it. They have low
pathogenicity and infection rate, and they create a kind of protection from the colonization
from other more pathogenic bacteria. The skin of Health Care Workers is colonized by 3.9 x
104 – 4.6 x 106 cfu / cm2. The micro organisms creating the resident flora are:
Staphylococcus epidermidis, Staphylococcus hominis, Microccoci, Propionibacterium,
Corynebacterium, Dermobacterium, Pitosporum, while in the transitional could be found
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter spp, Enterobacter spp and
Candida spp. The goal of hand hygiene is to eliminate the transient flora with a careful and
proper performance of hand wash, using different kind of soap, from the normal one to the
antiseptic, and alcohol based gel. The main problems found in the practice of hand hygiene is
connected with the lack of available sinks and time consuming performance of hand washing.
An easy way to resolve this problem could be the use of alcohol based hand rub, because of
its faster application compared to a correct hand washing.[23]
Although handwashing may seem like a simple process, it is often performed incorrectly.
Healthcare settings must continuously remind practitioners and visitors on the proper
procedure in washing their hands to comply with responsible handwashing. Simple programs
such as Henry the Hand, and the use of handwashing signals can assist healthcare facilities in
the prevention of nosocomial infections.
All visitors must follow the same procedures as hospital staff to adequately control the spread
of infections. Visitors and healthcare personnel are equally to blame in transmitting
infections.[citation needed] Moreover, multidrug-resistant infections can leave the hospital and
become part of the community flora if steps are not taken to stop this transmission.
In addition to handwashing, gloves play an important role in reducing the risks of
transmission of microorganisms. Gloves are worn for three important reasons in hospitals.
First, gloves are worn to provide a protective barrier and to prevent gross contamination of the
hands when touching blood, body fluids, secretions, excretions, mucous membranes, and
nonintact skin. In the USA, the Occupational Safety and Health Administration has mandated
wearing gloves to reduce the risk of bloodborne pathogen infection.[24] Second, gloves are
worn to reduce the likelihood that microorganisms present on the hands of personnel will be
transmitted to patients during invasive or other patient-care procedures that involve touching a
patient's mucous membranes and nonintact skin. Third, gloves are worn to reduce the
likelihood that hands of personnel contaminated with microorganisms from a patient or a
fomite can transmit these microorganisms to another patient. In this situation, gloves must be
changed between patient contacts, and hands should be washed after gloves are removed.
Wearing gloves does not replace the need for handwashing, because gloves may have small,
non-apparent defects or may be torn during use, and hands can become contaminated during
7. removal of gloves. Failure to change gloves between patient contacts is an infection control
hazard.
Surface sanitation
Sanitizing surfaces is an often overlooked, yet crucial component of breaking the cycle of
infection in health care environments. Modern sanitizing methods such as NAV-CO2 have
been effective against gastroenteritis, MRSA, and influenza. Use of hydrogen peroxide vapor
has been clinically proven to reduce infection rates and risk of acquisition. Hydrogen peroxide
is effective against endospore-forming bacteria, such as Clostridium difficile, where alcohol
has been shown to be ineffective.[25]
Antimicrobial surfaces
Microorganisms are known to survive on inanimate „touch‟ surfaces for extended periods of
time.[26] This can be especially troublesome in hospital environments where patients with
immunodeficiencies are at enhanced risk for contracting nosocomial infections.
Touch surfaces commonly found in hospital rooms, such as bed rails, call buttons, touch
plates, chairs, door handles, light switches, grab rails, intravenous poles, dispensers (alcohol
gel, paper towel, soap), dressing trolleys, and counter and table tops are known to be
contaminated with Staphylococcus, Methicillin-resistant Staphylococcus aureus (MRSA), one
of the most virulent strains of antibiotic-resistant bacteria and Vancomycin-resistant
Enterococcus (VRE).[27] Objects in closest proximity to patients have the highest levels of
staphylococcus, MRSA, and VRE. This is why touch surfaces in hospital rooms can serve as
sources, or reservoirs, for the spread of bacteria from the hands of healthcare workers and
visitors to patients.
Main article: Antimicrobial copper touch surfaces
Main article: Antimicrobial properties of copper
Copper alloy surfaces have intrinsic properties to destroy a wide range of microorganisms. In
the interest of protecting public health, especially in heathcare environments with their
susceptible patient populations, an abundance of peer-reviewed antimicrobial efficacy studies
have been and continue to be conducted around the world regarding copper‟s efficacy to
destroy E. coli O157:H7, methicillin-resistant Staphylococcus aureus (MRSA),
Staphylococcus, Clostridium difficile, influenza A virus, adenovirus, and fungi.[28]
Much of this antimicrobial efficacy work has been or is currently being conducted at the
University of Southampton and Northumbria University (United Kingdom), University of
Stellenbosch (South Africa), Panjab University (India), University of Chile (Chile), Kitasato
University (Japan), the Instituto do Mar[29] and University of Coimbra (Portugal), and the
University of Nebraska and Arizona State University (U.S.A.). A summary of the
antimicrobial copper touch surfaces clinical trials to date is available[30]
In 2007, U.S. Department of Defense‟s Telemedicine and Advanced Technologies Research
Center (TATRC) began to study the antimicrobial properties of copper alloys in a multi-site
clinical hospital trial conducted at the Memorial Sloan-Kettering Cancer Center (New York
City), the Medical University of South Carolina, and the Ralph H. Johnson VA Medical
8. Center (South Carolina).[31] Commonly-touched items, such as bed rails, over-the-bed tray
tables, chair arms, nurse's call buttons, IV poles, etc. were retrofitted with antimicrobial
copper alloys in certain patient rooms (i.e., the “coppered” rooms) in the Intensive Care Unit
(ICU). Early results disclosed in 2011 indicate that the coppered rooms demonstrated a 97%
reduction in surface pathogens versus the non-coppered rooms. This reduction is the same
level achieved by “terminal” cleaning regimens conducted after patients vacate their rooms.
Furthermore, of critical importance to health care professionals, the preliminary results
indicated that patients in the coppered ICU rooms had a 40.4% lower risk of contracting a
hospital acquired infection versus patients in non-coppered ICU rooms.[32][33][34] The U.S.
Department of Defense investigation contract, which is ongoing, will also evaluate the
effectiveness of copper alloy touch surfaces to prevent the transfer of microbes to patients and
the transfer of microbes from patients to touch surfaces, as well as the potential efficacy of
copper-alloy based components to improve indoor air quality.
In the U.S., the Environmental Protection Agency regulates the registration of antimicrobial
products. After extensive antimicrobial testing according to the Agency‟s stringent test
protocols, 355 copper alloys, including many brasses, were found to kill more than 99.9% of
methicillin-resistant Staphylococcus aureus (MRSA), E. coli O157:H7, Pseudomonas
aeruginosa, Staphylococcus aureus, Enterobacter aerogenes, and vancomycin-resistant
Enterococci (VRE) within two hours of contact.[35][36] Normal tarnishing was found to not
impair antimicrobial effectiveness.
On February 29, 2008, the United States Environmental Protection Agency (EPA) granted its
first registrations of five different groups of copper alloys as “antimicrobial materials” with
public health benefits.[37] The registrations granted antimicrobial copper as "a supplement to
and not a substitute for standard infection control practices." Subsequent registration
approvals of additional copper alloys have been granted. The results of the EPA-supervised
antimicrobial studies, demonstrating copper's strong antimicrobial efficacies across a wide
range of alloys, have been published.[38] These copper alloys are the only solid surface
materials to be granted “antimicrobial public health claims” status by EPA.
The EPA registrations state that laboratory testing has shown that when cleaned regularly:
Antimicrobial Copper Alloys continuously reduce bacterial contamination, achieving
99.9% reduction within two hours of exposure.
Antimicrobial Copper Alloy surfaces kill greater than 99.9% of Gram-negative and Gram-
positive bacteria within two hours of exposure.
Antimicrobial Copper Alloy surfaces deliver continuous and ongoing antibacterial action,
remaining effective in killing greater than 99% of bacteria within two hours.
Antimicrobial Copper Alloys surfaces kill greater than 99.9% of bacteria within two
hours, and continue to kill 99% of bacteria even after repeated contamination.
Antimicrobial Copper Alloys surfaces help inhibit the buildup and growth of bacteria
within two hours of exposure between routine cleaning and sanitizing steps.
Testing demonstrates effective antibacterial activity against Staphylococcus aureus,
Enterobacter aerogenes, Methicillin-resistant Staphylococcus aureus (MRSA),
Escherichia coli O157:H7, and Pseudomonas aeruginosa
The registrations state that “antimicrobial copper alloys may be used in hospitals, other
healthcare facilities, and various public, commercial and residential buildings.” A list of
antimicrobial copper products approved by the EPA is available.[39]
9. Aprons
Wearing an apron during patient care reduces the risk of infection.[citation needed] The apron
should either be disposable or be used only when caring for a specific patient.
Mitigation
The most effective technique of controlling nosocomial infection is to strategically implement
QA/QC measures to the health care sectors and evidence-based management can be a feasible
approach. For those VAP/HAP diseases (ventilator-associated pneumonia, hospital-acquired
pneumonia), controlling and monitoring hospital indoor air quality needs to be on agenda in
management[40] whereas for nosocomial rotavirus infection, a hand hygiene protocol has to be
enforced.[41][42][43] Other areas that the management needs to be covered include ambulance
transport.[citation needed]