Niosomes are novel drug delivery systems where medication is encapsulated in a non-ionic surfactant-based vesicle. They are similar to liposomes but are made of surfactant bilayers instead of phospholipid bilayers. Niosomes can be prepared in different sizes and methods to encapsulate both hydrophilic and hydrophobic drugs. They provide advantages over liposomes such as being more stable and having less variability. Niosomes show potential for targeted drug delivery and increasing drug bioavailability.