1. Neurons are the basic units of the nervous system that carry electrical impulses between cells.
2. Neurons transmit signals across junctions called synapses using either electrical or chemical transmission.
3. The chemical transmission theory involves the release of neurotransmitters from the presynaptic neuron that bind to receptors on the postsynaptic neuron, causing excitation or inhibition.
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations in the cell or outside it. Proteins can be targeted to the inner space of an organelle, different intracellular membranes, plasma membrane, or to exterior of the cell via secretion.
this ppt shares what synapses are and how information of one neuron is transmitted to other through the synapses. it also includes the properties and plasticity of synaptic transmission
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations in the cell or outside it. Proteins can be targeted to the inner space of an organelle, different intracellular membranes, plasma membrane, or to exterior of the cell via secretion.
this ppt shares what synapses are and how information of one neuron is transmitted to other through the synapses. it also includes the properties and plasticity of synaptic transmission
This presentation gives an overview of Lipid Rafts, how it was discovered, its importance and the future research in this area,Feel free to comment and ask any questions
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Cell is the smallest structural and functional unit in the body of living
organism and micro-organism. Cell has a Cell membrane in its outer most
part in case of animals and cell wall for plant and for plants, cell membrane
is present under the cell wall. Cell membrane has a scientific structure. So,
many scientists gives description about the structure of cell membrane like
Sandwich Model, Unit Membrane model and Fluid Mosaic Model. But,
the Fluid Mosaic Model is widely acceptable.
A cell cycle is a series of events that takes place in a cell as it grows and divides. The process has to be correct and regulated. This slide illustrated Cell cycle and its regulation. Check the slides to know more.
These slides contain the basic information and principle of nervous transduction, It also includes the information about the type of the neurons, structure of the neuron, resting and active membrane potential, synapes and events occurring in it, and introduction to the neurotransmitters.
This presentation gives an overview of Lipid Rafts, how it was discovered, its importance and the future research in this area,Feel free to comment and ask any questions
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Cell is the smallest structural and functional unit in the body of living
organism and micro-organism. Cell has a Cell membrane in its outer most
part in case of animals and cell wall for plant and for plants, cell membrane
is present under the cell wall. Cell membrane has a scientific structure. So,
many scientists gives description about the structure of cell membrane like
Sandwich Model, Unit Membrane model and Fluid Mosaic Model. But,
the Fluid Mosaic Model is widely acceptable.
A cell cycle is a series of events that takes place in a cell as it grows and divides. The process has to be correct and regulated. This slide illustrated Cell cycle and its regulation. Check the slides to know more.
These slides contain the basic information and principle of nervous transduction, It also includes the information about the type of the neurons, structure of the neuron, resting and active membrane potential, synapes and events occurring in it, and introduction to the neurotransmitters.
Nerve Impulse is defined as a wave of electrical chemical changes across the neuron that helps in the generation of the action potential in response to the stimulus. This transmission of a nerve impulse across the neuron membrane as a result of a change in membrane potential is known as Nerve impulse conduction.
Mechanism of Nerve Impulse Conduction
Nerve impulse conduction is a major process occurring in the body responsible for organized functions of the body. So, for conduction of nerve impulse there are two mechanisms:
Continuous conduction
Saltatory conduction
My first attempt at this presentation for the IB Diploma Programme Biology course: topic 6.5 neurons and synapses. I'm hoping another great educator out there can take this, make it look a lot better, and then share it :)
Thanks to Steven Taylor and Chris Paine for all of their work and inspiration.
Please download and modify as you wish.
final note: I actually made this in google slides - I just checked the presentation and none of the links to the videos I used are there. Here is a link to the google slide presentation so you can find the videos: https://docs.google.com/a/igbis.edu.my/presentation/d/1eabpxEtwlDGt7EPRqQ_GPwxUBerszZQquWAhjRnU_WE/edit?usp=sharing
This presentation contains the data about neurons, its types and the nerve conduction process extracted from Hickman's Integrated Principles of Zoology
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2. THE NEURON
A neuron also known as a neurone
or nerve cell is a cell that carries
electrical impulses. They are the
basic units of nervous system.
Every neuron is made up of
a cell body, dendrites and an axon.
4. SOME IMPORTANT TERMS
• SYNAPSE: the junction between the axon of
one neuron and dendrite, cell body or axon of
another neuron is know as synapse.
• SYNAPTIC KNOB: the swelling terminal of
axon or dendrites is known as synaptic knob.
• PRE SYNAPTIC NEURON: the neuron
carrying impulse towards synapse.
• POST SYNAPTIC NEURON: the neuron
carrying impulse away from the synapse.
5. TRANSMISSION OF NERVER IMPULSES
Nerve impulses have a domino effect.
Each neuron receives an impulse
and must pass it on to the next
neuron. To make sure that the
correct impulse continues on the
path, a series of chemical and
electrical events are carried out by
the neurons.
6. TWO THEORIES HAVE BEEN PUT
FORWARD TO EXPLAIN THE
TRANSMISSION OF NERVE IMPULSES
ACROSS THE SYNAPSE. THEY ARE;
1. ELECTRICAL TRANSMISSION THEORY
2. CHEMICAL TRANSMISSION THEORY
7. ELECTRICAL TRANSMISSION THEORY
Impulse transmission
through synapse is
accomplished by
electric current. When
the impulse reach the
pre synaptic knob, the
impulse itself act as
stimulus for the post
synaptic neuron
causing
depolarization. Now
8. POLARIZATION OF NEURON’S MEMBRANE
1. When the neuron is not
stimulated, its
membrane is said to be
polarized.
2. It means electric charge
on the outside of the
membrane is positive
while on the inside is
negative.
3. The outside of the cell
contains excess sodium
ions while the inside of
9. RESTING POTENITAL
When the neuron is
inactive and polarized,
it is said to be at its
resting potential. It
remains this way until a
stimulus comes along.
10. ACTION POTENTIAL
1. A stimulus from a
sensory cell or
another neuron
causes the target to
depolarize toward the
threshold potential.
2. If the threshold of
excitation is reached,
all Na channels open
and the membrane
depolarizes.
3. At the peak action
11. REPOLARIZATION
1. With potassium ions moving to the
outside, the membrane’s
repolarization restores electrical
balance.
2. Potassium ions move outside and
the sodium ions stay inside the
membrane.
12. HYPER POLARIZATION
1. More potassium ions are on the
outside than there are on the inside.
2. This cause membrane potential to
drop slightly lower than the resting
potential
3. The membrane have greater potential
is thus said to be hyper polarized.
13. REFRACTORY PERIOD
1. Refractory period puts everything back
to normal
2. Potassium returns inside while sodium
returns outside.
3. After the na/k pump return the ions to
the rightful sides, the neuron is back to
its normal polarized state until another
impulse comes along.
15. CHEMICAL TRANSMISSION THEORY
Nerve impulses are
conducted across the
synapse with the help of
chemical substances
called neurotransmitter.
The process of chemical
transmission was
discovered by Henry
(1936).
16. MECHANISM
1. Calcium gate opens.
2. Releasing a neurotransmitter.
3. The neurotransmitter binds with
receptors on the neuron.
4. Excitation or inhibition of the
membrane occurs.
