An action potential occurs when a neuron is stimulated enough to reach its threshold of excitation. This causes sodium channels to open, allowing sodium to rush into the neuron and depolarize it. The neuron then repolarizes as potassium leaves and the sodium-potassium pump restores the ion gradients. After an action potential, the neuron enters an absolute refractory period where it cannot fire again, followed by a relative refractory period where a stronger stimulus is needed to trigger another action potential. This process allows neurons to rapidly transmit signals down axons to synapse with other neurons.
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
Action potential By Dr. Mrs. Padmaja R Desai Physiology Dept
To study the Concept of Action Potential and describe the stages of action potential.
Ionic basis of Action Potential & its Propogation.
Properties of Action Potential.
Types action Potential
Nerve impluse in non myelinated and myelinated nerve fibres. Nerve impluse is the sum total of chemical and physical events in the propagation of a wave of physiological activity along a nerve fibre.
Propagation of nerve impluse in non myelinated nerve fibres-
Resting state
Depolarisation
Repolarization
Metabolic pump
The action potential
The process of Propagation of nerve impluse in myelinated nerve fibres is called soltatory propagation.
Nerve impluses are transmitted in one direction only. The nerve fibre always have a refractory period after a stimulus and the nerve impluses obey the all or none law
Sensory Neurons – picks up the stimuli (nerve impulse) and carries it to the spinal cord and brain.Interneurons- Found within the brain and spinal cord. Relays the message between the sensory neurons and the motor neurons. Motor Neurons – transfers impulses away from the brain to the spinal cord
Nerve Impulse is defined as a wave of electrical chemical changes across the neuron that helps in the generation of the action potential in response to the stimulus. This transmission of a nerve impulse across the neuron membrane as a result of a change in membrane potential is known as Nerve impulse conduction.
Mechanism of Nerve Impulse Conduction
Nerve impulse conduction is a major process occurring in the body responsible for organized functions of the body. So, for conduction of nerve impulse there are two mechanisms:
Continuous conduction
Saltatory conduction
description about neurones,
General introduction
Neurone classification – Myelinated and Non – Myelinated
Special features of a neurone
Resting Membrane Potential
Action Potential
Nerst Equation
Ionic distribution
Synaptic transmission
Conclusion.
Myelinated Neurone,nonMyelinated Neurone.
special properties of neurone(excitability,conduction,transmission,integration,excitability).
Rwsting membrane potential,action potential.nernst equation,ionic distribution of extracellular ions and intracellular ions.a little bit about how synaptic transmission occurs.from one nerve to another nerve.nerve impulse generation.neuro humoral transmission,etc.
Action potential By Dr. Mrs. Padmaja R Desai Physiology Dept
To study the Concept of Action Potential and describe the stages of action potential.
Ionic basis of Action Potential & its Propogation.
Properties of Action Potential.
Types action Potential
Nerve impluse in non myelinated and myelinated nerve fibres. Nerve impluse is the sum total of chemical and physical events in the propagation of a wave of physiological activity along a nerve fibre.
Propagation of nerve impluse in non myelinated nerve fibres-
Resting state
Depolarisation
Repolarization
Metabolic pump
The action potential
The process of Propagation of nerve impluse in myelinated nerve fibres is called soltatory propagation.
Nerve impluses are transmitted in one direction only. The nerve fibre always have a refractory period after a stimulus and the nerve impluses obey the all or none law
Sensory Neurons – picks up the stimuli (nerve impulse) and carries it to the spinal cord and brain.Interneurons- Found within the brain and spinal cord. Relays the message between the sensory neurons and the motor neurons. Motor Neurons – transfers impulses away from the brain to the spinal cord
Nerve Impulse is defined as a wave of electrical chemical changes across the neuron that helps in the generation of the action potential in response to the stimulus. This transmission of a nerve impulse across the neuron membrane as a result of a change in membrane potential is known as Nerve impulse conduction.
Mechanism of Nerve Impulse Conduction
Nerve impulse conduction is a major process occurring in the body responsible for organized functions of the body. So, for conduction of nerve impulse there are two mechanisms:
Continuous conduction
Saltatory conduction
description about neurones,
General introduction
Neurone classification – Myelinated and Non – Myelinated
Special features of a neurone
Resting Membrane Potential
Action Potential
Nerst Equation
Ionic distribution
Synaptic transmission
Conclusion.
Myelinated Neurone,nonMyelinated Neurone.
special properties of neurone(excitability,conduction,transmission,integration,excitability).
Rwsting membrane potential,action potential.nernst equation,ionic distribution of extracellular ions and intracellular ions.a little bit about how synaptic transmission occurs.from one nerve to another nerve.nerve impulse generation.neuro humoral transmission,etc.
Neuron communication belongs to subject ANIMAL PHYSIOLOGY in course of zoology.
nerve communication.
how neuron communicate?
RESTING MEMBRANE POTENTIAL
Measurement of Membrane Potential
These slides contain the basic information and principle of nervous transduction, It also includes the information about the type of the neurons, structure of the neuron, resting and active membrane potential, synapes and events occurring in it, and introduction to the neurotransmitters.
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India Orthopedic Devices Market: Unlocking Growth Secrets, Trends and Develop...Kumar Satyam
According to TechSci Research report, “India Orthopedic Devices Market -Industry Size, Share, Trends, Competition Forecast & Opportunities, 2030”, the India Orthopedic Devices Market stood at USD 1,280.54 Million in 2024 and is anticipated to grow with a CAGR of 7.84% in the forecast period, 2026-2030F. The India Orthopedic Devices Market is being driven by several factors. The most prominent ones include an increase in the elderly population, who are more prone to orthopedic conditions such as osteoporosis and arthritis. Moreover, the rise in sports injuries and road accidents are also contributing to the demand for orthopedic devices. Advances in technology and the introduction of innovative implants and prosthetics have further propelled the market growth. Additionally, government initiatives aimed at improving healthcare infrastructure and the increasing prevalence of lifestyle diseases have led to an upward trend in orthopedic surgeries, thereby fueling the market demand for these devices.
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Memorandum Of Association Constitution of Company.pptseri bangash
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A Memorandum of Association (MOA) is a legal document that outlines the fundamental principles and objectives upon which a company operates. It serves as the company's charter or constitution and defines the scope of its activities. Here's a detailed note on the MOA:
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Name Clause: This clause states the name of the company, which should end with words like "Limited" or "Ltd." for a public limited company and "Private Limited" or "Pvt. Ltd." for a private limited company.
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Registered Office Clause: It specifies the location where the company's registered office is situated. This office is where all official communications and notices are sent.
Objective Clause: This clause delineates the main objectives for which the company is formed. It's important to define these objectives clearly, as the company cannot undertake activities beyond those mentioned in this clause.
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Capital Clause: This clause specifies the authorized capital of the company, i.e., the maximum amount of share capital the company is authorized to issue. It also mentions the division of this capital into shares and their respective nominal value.
Association Clause: It simply states that the subscribers wish to form a company and agree to become members of it, in accordance with the terms of the MOA.
Importance of Memorandum of Association:
Legal Requirement: The MOA is a legal requirement for the formation of a company. It must be filed with the Registrar of Companies during the incorporation process.
Constitutional Document: It serves as the company's constitutional document, defining its scope, powers, and limitations.
Protection of Members: It protects the interests of the company's members by clearly defining the objectives and limiting their liability.
External Communication: It provides clarity to external parties, such as investors, creditors, and regulatory authorities, regarding the company's objectives and powers.
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Binding Authority: The company and its members are bound by the provisions of the MOA. Any action taken beyond its scope may be considered ultra vires (beyond the powers) of the company and therefore void.
Amendment of MOA:
While the MOA lays down the company's fundamental principles, it is not entirely immutable. It can be amended, but only under specific circumstances and in compliance with legal procedures. Amendments typically require shareholder
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5 Things You Need To Know Before Hiring a Videographer
The Resting Potential And The Action Potential
1.
2. When a neuron sends a signal down it’s axon
to communicate with another neuron, this is
called an action potential. When the action
potential reaches the end of the axon, it is at
the presynaptic terminal of the axon. There is a
gap (synaptic gap) between the axon and the
dendrite of the neighboring neuron, and the
message sent by the action potential must
cross this gap in order for the message to be
carried on to the next neuron (or in some
cases, to a muscle cell). The part of the
dendrite that the message must reach on the
other neuron across the gap is called the
postsynaptic terminal.
3. The electrical impulse carried by the action
potential must trigger the release of
neurotransmitter into the synaptic gap.
Neurotransmitters are the chemical
messengers that carry the message from
one neuron to the next. They are
contained in vesicles (tiny nearly spherical
packets) until they are released into the
synaptic gap.
4. The neurotransmitters cross the synaptic
gap and bind with the postsynaptic
terminal on the neighboring neuron. When
this binding takes place, the
neurotransmitter can make the
neighboring neuron either more likely or less
likely to fire an action potential down it’s
own axon. If an action potential occurs on
the postsynaptic side, then the message is
sent on to the next neuron in the chain.
5. Before an action potential occurs, the neuron is in
what is known as the resting potential. “At rest,”
there is an electrical charge difference between
the inside and the outside of the neuron because
of either positively or negatively charged ions. An
ion is an atom that has either gained or lost one or
more of its electrons. The ions that are most often
discussed when talking about action potentials are
sodium (Na+), potassium (K+) and Chloride (Cl-).
The inside of the neuron is more negatively
charged than the outside of the neuron, and the
neuron is said to be polarized (meaning that there
is a difference in electrical charge between the
inside and outside of the neuron). This prepares the
neuron for an action potential, and so the neuron is
said to be in dynamic equilibrium during the resting
potential and ready for a change in it’s electrical
charge.
6. During the resting potential, the membrane (or
covering) of the neuron keeps some chemicals
from passing back and forth from the inside to
the outside of the neuron or from the outside to
the inside of the neuron. The membrane is said
to be selectively permeable to chemicals. That
is, some chemicals pass through the
membrane more freely than others. There are
channels in the membrane that can permit
chemicals to pass into and out of the neuron.
During the resting potential, sodium channels
are completely closed, but potassium
channels are partly open, so potassium can
flow slowly out of the neuron.
7. Sodium is more than ten times more
concentrated outside the neuron’s membrane
than inside of the neuron. Sodium is removed
from inside the neuron and potassium is moved
from outside the neuron because of the
sodium-potassium pump. The sodium-
potassium pump is made of proteins and
transports sodium out of the cell and potassium
back into the cell. The selective permeability of
the cell membrane and the closed sodium
gates keeps the sodium that is pumped out of
the cell from coming back in.
8. Sodium concentrated
on the outside of the
cell has a positive
charge and chloride
has a negative charge.
Potassium (with a
positive charge) is
more heavily
concentrated inside
the cell. These
differences in the
charge of sodium,
potassium, and
chloride keeps the
neuron in dynamic
equilibrium and ready
for an action potential Neuron at rest. Sodium (Na+) and Chloride (Cl-) are
while the neuron is at more concentrated outside the neuron and
potassium (K+) are more concentrated inside the
rest. neuron during the resting potential.
9. An action potential happens when some event
happens that stimulates the neuron. This could be
someone poking you in the ribs with a pencil, the
teacher calling your name, or the smell of a
hamburger from a fast food restaurant, for example.
If the stimulation gets our attention, then the neuron
has gone from a polarized to a depolarized state.
Depolarization occurs when polarization is reduced
toward zero. In the resting state, the charge inside
the cell was about -70 mV. If the stimulation is strong
enough (is beyond what is known as the threshold of
excitation), then there is a sudden, massive
depolarization of the membrane and an action
potential occurs. This occurs because the
membrane suddenly opens the sodium channels
and allows a rapid and massive flow of sodium
across the membrane and into the neuron.
10. The proteins in the membrane that control the
entry of sodium into the cell are called
voltage-activated channels, and these
channels depend on how permeable the
membrane is and the voltage difference
across the membrane, and this depends on
whether the sodium gates are opened or
closed. During the resting potential, the sodium
gates are closed, but during the action
potential the sodium gates open wide and
sodium flows freely into the cell. At the peak of
the action potential, the inside of the neuron is
positively charged rather than negatively
charged as a result of the flow of sodium into
the cell.
11. After the peak of the action potential, the
potassium channels open and potassium ions
flows out of the axon, carrying their positive
charge along with them. Enough potassium
leaves the neuron to make it even more
negative on the inside of the cell than it was
during the resting potential. This is known as
hyperpolarization. The sodium-potassium pump
also begins to pump sodium from inside the
cell to the outside of the cell again. The neuron
then slowly returns to the resting potential
again.
12. Resting state to action potential. The neuron goes from a polarized state at the resting potential (1)
with the neuron more negatively charged inside than outside the membrane to a depolarized state
during the action potential (2) with the cell positively charged on the inside. After the action
potential, the neuron begins to return to a state of polarization (a return to the resting state) (3). It
first overshoots and becomes hyperpolarized (even more negatively charged on the inside of the
neuron than in the resting state) (4) and then returns to the resting state (1).
13. When an action potential occurs, it follows
what is known as the all-or-none law. That is,
the speed and size/range of the action
potential is the same, no matter how weak or
strong the stimulus was that caused the action
potential. Whether someone pokes you with
the eraser end of a pencil or smacks you with a
boat oar, the action potential would be the
same. That is, if the stimulus was strong enough
to cross the threshold of excitement in the first
place, the action potential would occur the
same way every time. Other factors, such as
the timing of action potentials, are what allows
us to determine the strength of a stimulus.
14. Immediately after an action potential, the
neuron enters a refractory period, during which
it is resistant to producing any additional action
potentials. During the first part of the refractory
period, the membrane cannot produce an
action potential, regardless of how strong a
stimulus is. This is known as the absolute
refractory period. After a period of time, a
stronger than usual stimulus could initiate an
action potential. This is known as the relative
refractory period. After a brief period of time
(possibly four milliseconds), the neuron returns
to normal and can again produce an action
potential.