This document discusses mutations and techniques for detecting mutations using gold nanoparticles. It begins with definitions of genetic terminology and describes the different types of mutations including point mutations, frameshift mutations, and chromosomal mutations. It then explains that gold nanoparticles are well-suited for mutation detection due to their chemical inertness, biocompatibility, and surface plasmon resonance properties. The document outlines a method using gold nanoparticles for colorimetric detection of point mutations based on changes in nanoparticle aggregation and color. It concludes that gold nanoparticle detection of mutations provides sensitive, specific, low-cost analysis with naked-eye results.