This paper analyzes the reliability of MOSFETs that use indium-tin oxide as the gate oxide instead of silicon dioxide. Interface trap charges at the oxide-silicon interface can degrade MOSFET performance by changing the threshold voltage over time. The paper finds that MOSFETs using indium-tin oxide exhibit improved immunity to the effects of interface trap charges compared to those using silicon dioxide. Specifically, indium-tin oxide MOSFETs show enhanced static, linearity, and intermodulation performance metrics when subjected to both positive and negative interface trap charges. Thus, indium-tin oxide has potential to improve MOSFET reliability by reducing sensitivity to interface trap charge effects.