This document defines mental retardation as significantly below average intellectual functioning and impaired adaptive behaviors that manifest during development. It estimates the prevalence of mental retardation globally and in India. Causes include genetic factors like Down syndrome, metabolic disorders, infections during pregnancy, birth complications, and childhood illnesses. Mental retardation is classified by IQ scores into mild, moderate, severe and profound. Signs and symptoms, diagnosis, treatment including behavioral management and nursing care are discussed. The prognosis has improved with early intervention and mainstream education focusing on developing life skills.