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Malaria
What causes malaria?
These are the symptoms
Mosquitoes spread the disease
They transmit the disease
They are vectors
The mosquito bites humans
Symptoms develop in about 15 days
Plasmodium parasite
Infection with Plasmodium parasite …
… is called malaria
Complicated life cycle
Sporozoites are infectious cells
Sporozoites develop in the mosquito’s
saliva
The mosquito bites humans
Enter the human body
Sporozoites enter the liver
Hypnozoites may “sleep” in the liver
up to 30 years
Merosomes and merozoites infect the
red blood cells
Mosquito takes up gametocytes
Different stages, different names
The malaria parasite is known
generally as Plasmodium
Plasmodium falciparum
75% of deaths in Africa …
… caused by plasmodium falciparum
Infection travels to the blood
Transmitted TO the mosquito when
they bite infected patients
Malaria parasite has TWO hosts
For example, a human and a mosquito
About 200 million cases of malaria
every year
About a million deaths every year
Most cases in Africa
I lived in Sudan for one year
You need a net
Smallpox vaccine
Very successful
Smallpox has been eradicated
There’s no malaria vaccine
Malaria parasites are getting stronger
Anti-malaria drugs
Artesunate – mentioned in the book
Treatment for severe malaria
Also mentioned
Prevention AND treatment
Artemisinin-based combination
treatment
A combination of drugs
Here’s mefloquine
Synthetic analogue of Quinine
Quinine has been used since (at least)
the 17th century
Perhaps earlier
Quinine discovered in South America
Europeans were told about it in the
16th century
Quinine from a tree’s bark
Quinchona tree
Long history
Tonic water contains Quinine
Gin and tonic
British in India
G & T against Malaria
Artemisinin-combination therapies
(ACTs)
Artemisinin is used in Chinese
medicine
Derived from a plant
People were optimistic
Parasites already resistant to
chloroquine
Resistant to this, too
Sulphadoxine-pyrimethamine
Pailin in Cambodia
Pailin in Cambodia
Parasite is becoming resistant to ACTs
This is particularly worrying …
… because resistance to drugs …
… has started here before.
If resistance spreads to Africa …
… it’s really a problem
It’s a DISASTER
So what’s the solution?
Eradicate Malaria
Quickly
Do it now!
Discover a vaccine
Before the end of the class!
You’ll get a Nobel Prize
And an automatic A for this course
Maybe even A ➕
But don’t forget …
… there’s a LONG history
These parasites are tough
We’ve been thinking about this …
… for a LONG time
The parasite keeps winning
Still there’s hope
Guinea worm
People drink infected water
The worm grows in the stomach
Comes out of the skin!
Like this!
Really bad
Only dogs and humans get it
Gradually removed …
By winding it around a stick!
Up to one meter long
How can it be eradicated?
• No vaccine
• But we can kill the baby worms
• And water can be cleaned
• 3.5 million cases of Guinea worm in 1986!
• 126 cases in 2014
• That’s great!!
• Unless you are one of the 126 cases

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