Leishmania is a genus of protozoan parasites that causes leishmaniasis, a vector-borne disease spread by sandfly bites. It exists in two forms: amastigotes within host cells and promastigotes in sandflies. The disease manifests as visceral, cutaneous, or mucocutaneous leishmaniasis depending on the infected tissues. Visceral leishmaniasis affects internal organs while cutaneous primarily affects the skin. Diagnosis involves detecting the parasites microscopically or through culture. Treatment involves pentavalent antimonials, amphotericin B, or miltefosine. Control relies on reducing sandfly and reservoir populations through insecticides and treating
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
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LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
Entamoeba histolytica was first discovered by Losch in 1875.
It is worldwide distribution.
It is prevalent in tropical and subtropical countries where sanitary conditions are poor.
In india, it is prevalent in Chandigarh, Tamil Nadu & Maharashtra.
It is found in the colon of man.
It is monogenetic because the whole life cycle completed within a single host, i.e. man.
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
Entamoeba histolytica was first discovered by Losch in 1875.
It is worldwide distribution.
It is prevalent in tropical and subtropical countries where sanitary conditions are poor.
In india, it is prevalent in Chandigarh, Tamil Nadu & Maharashtra.
It is found in the colon of man.
It is monogenetic because the whole life cycle completed within a single host, i.e. man.
By the end of this presentation we’ll be able to learn about- -Geographical distribution of leishmania parasites- Know the different stages of leishmania parasites and their morphology.-Describe the lifecycle of leishmania.-Causes and pathogenesis of leishmania -Preventive measures of leishmaniasis
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
nd invade the genital ridges in the sixth week of
development. here they form primitive sex cords. in
the absence of tdf, medullary cords disappear and
get replaced by a vascular stroma (ovarian medulla).
cortical cords develop and surround one or more
primitive germ cells. the germ cells subsequently
develop into oogonia, while the surrounding epithelial
cells form the follicular cells. this differentiates
undifferentiated gonads into ovaries. stroma of ovary
develops from basal mesenchyme. granulosa and theca
cells develop from celomic epithelium.
development of genital ducts
development of genital duct system and the external
genitalia occurs under the influence of hormones
circulating in the fetus. sertoli cells in the fetal testes
produce a nonsteroidal substance known as müllerian
inhibiting substance (mis) that causes regression of
müllerian ducts. androgen from the fetal testes causes
masculinization of external genitalia. in the absence of
mis, müllerian ducts develop and mesonephric duct
system regresses. in the absence of androgen, external
genitalia differentiate into female phenotype. the
müllerian duct develops between the fifth and sixth
weeks lateral to intermediate cell mass and wolffian
duct. the müllerian duct has the following three parts:
•cranial vertical portion that opens into celomic
cavity. later it differentiates into fallopian tubes.
•horizontal part crosses the mesonephric duct.
•caudal vertical part that fuses with its partner
from opposite side. this fused part later differ
entiates into uterus, cervix, and upper one-third
of the vagina.
the dorsal celomic epithelium (which forms
müllerian duct) remains open at its site of origin and
ultimately forms the fimbriated ends of the fallopian
tubes. at their point of origin, each of the müllerian
ducts forms a solid bud. each bud penetrates the
mesenchyme lateral and parallel to the wolffian duct.
as the solid buds elongate, a lumen appears in the
cranial part, beginning at each celomic opening. the
caudal end of each müllerian duct crosses the way
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
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Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
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Palestine last event orientationfvgnh .pptxRaedMohamed3
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
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3. INTRODUCTION
Leishmania:
•
Is a genus of trypanosomatid protozoa, which
causes a fatal vector-borne parasitic disease called
Leishmaniasis.
It is spread by the bite of sandflies of the genus
Phlebotomus in the Old World, and of the genus
Lutzomyia in the New World.
• Leishmaniasis:
• is the second-largest parasitic killer in the world
(after malaria) and is endemic in many parts of
Africa, Asia and South America.
6. HABITAT
(L.donovani)
Are essentially the parasites of visceral organs.
Promastigote forms found in sand fly and in culture.
Amastigote forms found in man in
reticuloendothelial cells of
spleen,
bone marrow,
liver,
intestinal mucosa,
mesentric lymph node.
7. MORPHOLOGY
(same in all species)
• The parasite exists in
2 forms;1. Amastigotes –
aflagellar stage
2. Promastigotesflagellar stage
8. Morphological Differences
Amastigotes
Promastigotes
•
Aflagellar stage
•
Flagellar stage
•
Occurs in the vertebrate host
•
Occurs in the sand fly
•
divides by binary fission at 37oC.
•
divides by binary fission at 27oC.
•
There are round or oval ;2-4µm along
longitudinal axis.
•
They are spindle shaped ;15-20 µm in
Nucleus relatively larger and situated
centrally.
•
•
length & 1-2µm in width.
Nucleus smaller and situated in the
middle of the cell or along the side of
cell-wall.
10. Life cycle of other species of Leishmania are similar to
L.donovani except that
In L.tropica
• amastigotes reside in the large mononuclear cells
of the skin
In L.mexicana
• Amastigotes found in reticuloendothelial cells
and lymphatic tissues of skin
In L.braziliensis
• amastigotes are found in reticuloendothelial cells
and lymphatic tissues of skin and mucus
membrane
11. MODE OF TRAMSMISSION
(L.donovani)
1. Mainly by the bite of sand fly (vector) Phlebotomus
argentipus
2. LesS frequently by:
blood transfusion,
congenital infection,
accidental inoculation of cultured promastigotes in the lab.
Workers.
sexual intercourse.
Males are affected more (due to increased exposure to sand
flies through the occupation and leisure activities).
14. CLINICAL MANIFESTATIONS
1. Fever
2. Spleen enlargement
3. Lymphadenopathy
4. Darkening of the skin (KALA AZAR, MEANING “BLACK FEVER)
Complications:- pneumonia, TB, dysentery, uncontrolled haemorrhage
Prognosis:- With an early treatment, cure rate >90%
If not treated, death occurs within 2 years.
15. TYPES OF
LEISHMANIASIS
Leishmaniasis is divided into clinical syndromes
according to what part of the body is affected most.
Visceral Leishmaniasis(VL)
Cutaneous Leishmaniasis(CL)
Mucocutaneous leishmaniasis(MCL)
17. Continued....
2.
Cutaneous
Leishmaniasis(CL)
( most common type)
a)
Old world CL:- caused by
L.tropica, L. aethiopica
b)
New world CL:- caused by
L.mexicana, L.braziliensis, L.g
uyanensis
c) Dermal leishmanoid or Post
kala-azar dermal
leishmaniasis(PKDL):- caused
by L.donovani
Part of the body most affected
is skin
23. Direct Evidences (....contd)
3. Biopsy material obtained
•
•
•
by
lymph node puncture,
sternal or iliac crest
puncture(marrow) and
spleen puncture(spleen
pulp)
Amastigote form in a stained smear
Promastigote in culture in NNN medium
Amastigotes of L. donovani.
Splenic aspirate.
24. PREVENTION AND CONTROL
Reduction of
Reduction of sand
fly population
reservoir
by killing all the infected dogs in the
cases of zoonotic kala-azar.
by insecticides mainly
DDT, dieldrin, malathion
PREVENTION AND
CONTROL
Education in the
community
Prevention of
exposure to sand fly
About the causes and modes of
transmission of leishmaniasis.
using insect repellent, bed nets and window
mess as needed.
There are No
Vaccines to prevent leishmaniasis.
26. TREATMENT
Sodium
stibogluconate
solution
Inhibits glycolytic enzymes and fatty acid
oxidation
Amphotericin
B
Drugs
Binds with ergosterol leading to the altered
permeability to cations, water, glucose and affect
membrane-bound enzymes.
Pentamidine
Inhibits DHFR and interferes with aerobic glycolysis
in protozoa, also inhibits protein synthesis
Miltefosine
Effects cell-signaling pathways and synthesis of the
cell-membrane
Interferon
macrophage activation