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Control of the Internal
Environment
Control of the Internal
Environment
Objectives
 Define the terms homeostasis and steady state
 Diagram and discuss a biological control system
 Give an example of a biological control system
 Explain negative feedback
 Define what is meant by the gain of a control
system
Glossary
 Maintain – keep up.
 Constant – the same.
 Internal – inside the body.
 Environment – surroundings of the body.
 Feedback - a cycle in which the output of a system
“feeds back” to modify or reinforce the actions of the
system in order to maintain homeostasis.
 Thermoneutral Zone- describes a range of
temperatures of the immediate environment in which
a standard healthy adult can maintain normal body
temperature without needing to use energy above and
beyond normal basal metabolic rate
What is Homeostasis?
 Body cells work best if they have the correct
 Temperature
 Water levels
 Glucose concentration
 Your body has mechanisms to keep the cells in a
constant environment.
Homeostasis
 Maintenance of a constant internal environment is
called homeostasis
 When the body’s biological control systems
maintain physiological variables at manageable
constant values at rest, (when the body is not under
any stress) it is called homeostasis.
 Blood pressure–Body temperature–
Blood glucose levels
Steady State
 It is a Balance between the demands placed on a
body and the physiological response to those
demands
 Maintenance of an internal environment by a
biological control system, where a physiological
variable (e.g. body temperature) remains
relatively constant yet deviates from its normal
value, which occurs when the body is experiencing
stress (e.g. exercise).
Body Core Temperature During
Exercise
Changes in body core temperature during
submaximal exercise
Body temperature reaches
a plateau (steady state)
 To distinguishing between these two terms is the case of
body temperature during exercise.
 Graph illustrates the changes in body core temperature
during sixty minutes of constant-load submaximal exercise in
a thermoneutral environment
 Core temperature reaches a new and steady level within forty
minutes after commencement of exercise.
 This plateau of core temperature represents a steady state,
since temperature is constant; however, this constant
temperature is above the normal resting body temperature
and thus does not represent a true homeostatic condition.
 Therefore, the term homeostasis is generally reserved for
In Summary
 Homeostasis is defined as the maintenance of a
constant or unchanging “normal” internal environment
during unstressed conditions.
 The term steady state is also defined as a constant
internal environment, but this does not necessarily
mean that the internal environment is at rest and
normal. When the body is in a steady state, a balance
has been achieved between the demands placed on
the body and the body’s response to those demands.
Homeostasis: Dynamic Constancy
Control Systems of the Body
 The body has literally hundreds of different
control systems
 Intracellular control systems
 Protein breakdown and synthesis
 Energy production
 Maintenance of stored nutrients
 Organ systems
 Pulmonary and circulatory systems
 Replenish oxygen and remove carbon dioxide
Control Systems of the Body
Control Systems of the Body
 Goal
 To regulate some physiological variable at or near
constant value
 Maintain homeostasis
Non-Biological Control System
 if room
Temperature
below 200 C
Thermostat set
at 200 C
Heating System
Room
temperature
Returns to 200 C
Room Temperature
Signals thermostat
To turn off heat
Non-Biological Control System
A thermostat-controlled
heating/cooling system
An increase in temperature
above the set point signals
the air conditioner to turn on.
A decrease in room
temperature below the set
point results in turning on the
furnace.
Nature of the Control Systems
Biological Control Systems
 Series of interconnected components that serve
to maintain a physical or chemical parameter at or
near constant
 Receptor
 Capable of detecting changes
 Integrating center
 Assesses input and initiates response
 Effector
 Corrects changes to internal environment
Components of a Biological Control System
Negative Feedback
 Most control systems of the body operate via negative
feedback
 Response reverses the initial disturbance in
homeostasis
 feedback is termed negative is that the
response of the control system is negative
(opposite) to the stimulus.
 An example of negative feedback can be seen in the
respiratory system's regulation of the CO 2
concentration in extracellular fluid.
 Example:
 Increase in extracellular CO2 triggers a receptor
 Sends information to respiratory control center
Positive Feedback
 Response increases the original stimulus
 Feedback is termed positive because the response
is in the same direction as the stimulus.
 Example:
 Initiation of childbirth stimulates receptors in cervix
 Sends message to brain
 Release of oxytocin from pituitary gland
 Oxytocin promotes increased uterine contractions
Nature of the Control Systems
Gain of a control system
 The precision with which a control system maintains
homeostasis is called the gain of the system
OR
 Degree to which a control system maintains homeostasis
 Gain can be thought of as the “capability” of the control
system
 System with large gain is more capable of maintaining
homeostasis than system with low gain
 Pulmonary and cardiovascular systems have large
gains
 All these systems deal with life-and-death issues.
Nature of the Control Systems
In Summary
 A biological control system is composed of a
sensor, a control center, and an effectors.
 Most control systems act by way of negative
feedback.
 The degree to which a control system maintains
homeostasis is termed the gain of the system. A
control system with a large gain is more capable
of maintaining homeostasis than a system with a
low gain.
Nature of the Control Systems
Examples of Homeostatic Control
 Regulation of body temperature
 Thermal receptors send message to brain
 Response by skin blood vessels and sweat glands
regulates temperature
Examples of Homeostatic Control
Regulation of Body
Temperature
Negative feedback
mechanism to regulate
body temperature
Examples of Homeostatic Control
Examples of Homeostatic Control
 Regulation of blood glucose
 Requires the hormone insulin
 Diabetes
 Failure of blood glucose control system
Example: Regulation of Blood Glucose
The pancreas acts as
both the sensor and
effector organ
Failure of a Biological Control System
Results in Disease
 Failure of any component of a control system
results in a disturbance of homeostasis
 Example:
 Type 1 diabetes
 Damage to beta cells in pancreas
 Insulin is no longer released into blood
 Hyperglycemia results
 This represents failure of “effector”
Examples of Homeostatic Control
Exercise
 Exercise disrupts homeostasis by changes in pH,
O2, CO2, and temperature
 Control systems are capable of maintaining
steady state during submaximal exercise in a cool
environment
 Intense exercise or prolonged exercise in a
hot/humid environment may exceed the ability to
maintain steady state.
 May result in fatigue and cessation of exercise
Exercise: A Test of Homeostatic Control
In Summary
 Exercise represents a challenge to the body’s
control systems to maintain homeostasis.
 In general, the body’s control systems are
capable of maintaining a steady state during most
types of exercise in a cool environment.
 However, intense exercise or prolonged work in a
hostile environment (i.e., high temperature/
humidity) may exceed the ability of a control
system to maintain steady state, and severe
disturbances of homeostasis may occur.
Exercise: A Test of Homeostatic Control
Exercise: A Test of Homeostatic
Control
 Submaximal exercise in a cool environment
 The body’s control systems can maintain steady
state
 Maximal exercise or exercise in a hot/humid
environment
 May not be able to maintain steady state
 Severe disturbances in homeostasis can occur
Lec 1b control of internal envorment

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Lec 1b control of internal envorment

  • 1. Control of the Internal Environment Control of the Internal Environment
  • 2. Objectives  Define the terms homeostasis and steady state  Diagram and discuss a biological control system  Give an example of a biological control system  Explain negative feedback  Define what is meant by the gain of a control system
  • 3. Glossary  Maintain – keep up.  Constant – the same.  Internal – inside the body.  Environment – surroundings of the body.  Feedback - a cycle in which the output of a system “feeds back” to modify or reinforce the actions of the system in order to maintain homeostasis.  Thermoneutral Zone- describes a range of temperatures of the immediate environment in which a standard healthy adult can maintain normal body temperature without needing to use energy above and beyond normal basal metabolic rate
  • 4. What is Homeostasis?  Body cells work best if they have the correct  Temperature  Water levels  Glucose concentration  Your body has mechanisms to keep the cells in a constant environment.
  • 5. Homeostasis  Maintenance of a constant internal environment is called homeostasis  When the body’s biological control systems maintain physiological variables at manageable constant values at rest, (when the body is not under any stress) it is called homeostasis.  Blood pressure–Body temperature– Blood glucose levels
  • 6. Steady State  It is a Balance between the demands placed on a body and the physiological response to those demands  Maintenance of an internal environment by a biological control system, where a physiological variable (e.g. body temperature) remains relatively constant yet deviates from its normal value, which occurs when the body is experiencing stress (e.g. exercise).
  • 7. Body Core Temperature During Exercise Changes in body core temperature during submaximal exercise Body temperature reaches a plateau (steady state)
  • 8.  To distinguishing between these two terms is the case of body temperature during exercise.  Graph illustrates the changes in body core temperature during sixty minutes of constant-load submaximal exercise in a thermoneutral environment  Core temperature reaches a new and steady level within forty minutes after commencement of exercise.  This plateau of core temperature represents a steady state, since temperature is constant; however, this constant temperature is above the normal resting body temperature and thus does not represent a true homeostatic condition.  Therefore, the term homeostasis is generally reserved for
  • 9. In Summary  Homeostasis is defined as the maintenance of a constant or unchanging “normal” internal environment during unstressed conditions.  The term steady state is also defined as a constant internal environment, but this does not necessarily mean that the internal environment is at rest and normal. When the body is in a steady state, a balance has been achieved between the demands placed on the body and the body’s response to those demands. Homeostasis: Dynamic Constancy
  • 10. Control Systems of the Body  The body has literally hundreds of different control systems  Intracellular control systems  Protein breakdown and synthesis  Energy production  Maintenance of stored nutrients  Organ systems  Pulmonary and circulatory systems  Replenish oxygen and remove carbon dioxide Control Systems of the Body
  • 11. Control Systems of the Body  Goal  To regulate some physiological variable at or near constant value  Maintain homeostasis
  • 12. Non-Biological Control System  if room Temperature below 200 C Thermostat set at 200 C Heating System Room temperature Returns to 200 C Room Temperature Signals thermostat To turn off heat
  • 13. Non-Biological Control System A thermostat-controlled heating/cooling system An increase in temperature above the set point signals the air conditioner to turn on. A decrease in room temperature below the set point results in turning on the furnace. Nature of the Control Systems
  • 14. Biological Control Systems  Series of interconnected components that serve to maintain a physical or chemical parameter at or near constant  Receptor  Capable of detecting changes  Integrating center  Assesses input and initiates response  Effector  Corrects changes to internal environment
  • 15. Components of a Biological Control System
  • 16. Negative Feedback  Most control systems of the body operate via negative feedback  Response reverses the initial disturbance in homeostasis  feedback is termed negative is that the response of the control system is negative (opposite) to the stimulus.  An example of negative feedback can be seen in the respiratory system's regulation of the CO 2 concentration in extracellular fluid.  Example:  Increase in extracellular CO2 triggers a receptor  Sends information to respiratory control center
  • 17. Positive Feedback  Response increases the original stimulus  Feedback is termed positive because the response is in the same direction as the stimulus.  Example:  Initiation of childbirth stimulates receptors in cervix  Sends message to brain  Release of oxytocin from pituitary gland  Oxytocin promotes increased uterine contractions Nature of the Control Systems
  • 18. Gain of a control system  The precision with which a control system maintains homeostasis is called the gain of the system OR  Degree to which a control system maintains homeostasis  Gain can be thought of as the “capability” of the control system  System with large gain is more capable of maintaining homeostasis than system with low gain  Pulmonary and cardiovascular systems have large gains  All these systems deal with life-and-death issues. Nature of the Control Systems
  • 19. In Summary  A biological control system is composed of a sensor, a control center, and an effectors.  Most control systems act by way of negative feedback.  The degree to which a control system maintains homeostasis is termed the gain of the system. A control system with a large gain is more capable of maintaining homeostasis than a system with a low gain. Nature of the Control Systems
  • 20. Examples of Homeostatic Control  Regulation of body temperature  Thermal receptors send message to brain  Response by skin blood vessels and sweat glands regulates temperature Examples of Homeostatic Control
  • 21. Regulation of Body Temperature Negative feedback mechanism to regulate body temperature Examples of Homeostatic Control
  • 22. Examples of Homeostatic Control  Regulation of blood glucose  Requires the hormone insulin  Diabetes  Failure of blood glucose control system
  • 23. Example: Regulation of Blood Glucose The pancreas acts as both the sensor and effector organ
  • 24. Failure of a Biological Control System Results in Disease  Failure of any component of a control system results in a disturbance of homeostasis  Example:  Type 1 diabetes  Damage to beta cells in pancreas  Insulin is no longer released into blood  Hyperglycemia results  This represents failure of “effector” Examples of Homeostatic Control
  • 25. Exercise  Exercise disrupts homeostasis by changes in pH, O2, CO2, and temperature  Control systems are capable of maintaining steady state during submaximal exercise in a cool environment  Intense exercise or prolonged exercise in a hot/humid environment may exceed the ability to maintain steady state.  May result in fatigue and cessation of exercise Exercise: A Test of Homeostatic Control
  • 26. In Summary  Exercise represents a challenge to the body’s control systems to maintain homeostasis.  In general, the body’s control systems are capable of maintaining a steady state during most types of exercise in a cool environment.  However, intense exercise or prolonged work in a hostile environment (i.e., high temperature/ humidity) may exceed the ability of a control system to maintain steady state, and severe disturbances of homeostasis may occur. Exercise: A Test of Homeostatic Control
  • 27. Exercise: A Test of Homeostatic Control  Submaximal exercise in a cool environment  The body’s control systems can maintain steady state  Maximal exercise or exercise in a hot/humid environment  May not be able to maintain steady state  Severe disturbances in homeostasis can occur