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INTRODUCTION TO HOMEOSTASIS
Important variables within the body:
 blood sugar
 fluid balance
 body temperature
 oxygen levels
 blood pressure
 pH
These variables must stay within certain ranges.
Changes in the external environment can cause these
variables to change.
Homeostasis
Definition
The process by which a stable internal environment is
maintained despite changes in the external
environment.
Dynamic equilibrium
 Homeostasis is also called dynamic equilibrium:
 Conditions do fluctuate, but within an acceptable range
Factors affecting homeostasis
 Disease
 Stress
 Lifestyle
 Injury
 Dehydration
 Genetic factors
 Outside temperature
Components of a homeostatic control system:
Component Function
Receptor recieves information that something in the
environment is changing
Co-ordinating centre receives and processes information from the
receptor
effector carries out the response initiated by the co-
ordinating centre
Example of homeostasis in action
Components Example
Receptor Cutaneous receptors of
the skin
Control centre Brain
Effector Blood vessels and
sweat glands in the skin
The hypothalamus
 Part of the brain
 Often serves as the co-ordinating centre:
 Receives messages from monitors
 Initiates a hormonal/nervous response
How is dynamic equilibrium
maintained?
 Feedback systems
 Negative feedback
 Positive feedback
Negative feedback
 Negative feedback: Response triggered by changed
conditions serves to reverse the change
 E.g., Body temperature increases  Skin blood vessels
dilate  Body temperature decreases
Body temperature
increases
Hypothalamus
sends a message
to blood vessels
Skin blood vessels
dilate
Body temperature
decreases
Normal
body
temperature
Positive feedback
 Positive feedback: The response triggered by changing
conditions serves to move the variable even further away
from its steady state
 E.g., uterine contractions are stimulated by oxytocin 
baby moves towards cervix  more oxytocin is released
Role of various systems in homeostasis
 Respiratory system, blood and kidneys helps in
regulating pH, of ECF, which is 7.4.
 Pancreas regulates blood glucose levels with the
relese of insulin or glucogan.
 Skin, respiratory, digestive, excretery, nervous system
and skeletal muscles are involved in maintaining body
temperatur of 37.5.
 Digestive system and circulatory systems play major
role in supply of nutrients to cells.
 Respiratory system supply oxygen to body cells and
remove carbon dioxide from body.
 Kidneys are involved in excretion of waste products.
 Hormones are to be synthesized and released from
endocrine glands in approprite quantities.
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lec 2 Homeostasis and its mechanism with examples

  • 2. Important variables within the body:  blood sugar  fluid balance  body temperature  oxygen levels  blood pressure  pH These variables must stay within certain ranges. Changes in the external environment can cause these variables to change.
  • 3. Homeostasis Definition The process by which a stable internal environment is maintained despite changes in the external environment.
  • 4.
  • 5. Dynamic equilibrium  Homeostasis is also called dynamic equilibrium:  Conditions do fluctuate, but within an acceptable range
  • 6. Factors affecting homeostasis  Disease  Stress  Lifestyle  Injury  Dehydration  Genetic factors  Outside temperature
  • 7. Components of a homeostatic control system: Component Function Receptor recieves information that something in the environment is changing Co-ordinating centre receives and processes information from the receptor effector carries out the response initiated by the co- ordinating centre
  • 8. Example of homeostasis in action Components Example Receptor Cutaneous receptors of the skin Control centre Brain Effector Blood vessels and sweat glands in the skin
  • 9.
  • 10. The hypothalamus  Part of the brain  Often serves as the co-ordinating centre:  Receives messages from monitors  Initiates a hormonal/nervous response
  • 11. How is dynamic equilibrium maintained?  Feedback systems  Negative feedback  Positive feedback
  • 12. Negative feedback  Negative feedback: Response triggered by changed conditions serves to reverse the change  E.g., Body temperature increases  Skin blood vessels dilate  Body temperature decreases
  • 13. Body temperature increases Hypothalamus sends a message to blood vessels Skin blood vessels dilate Body temperature decreases Normal body temperature
  • 14. Positive feedback  Positive feedback: The response triggered by changing conditions serves to move the variable even further away from its steady state  E.g., uterine contractions are stimulated by oxytocin  baby moves towards cervix  more oxytocin is released
  • 15.
  • 16.
  • 17. Role of various systems in homeostasis  Respiratory system, blood and kidneys helps in regulating pH, of ECF, which is 7.4.  Pancreas regulates blood glucose levels with the relese of insulin or glucogan.  Skin, respiratory, digestive, excretery, nervous system and skeletal muscles are involved in maintaining body temperatur of 37.5.  Digestive system and circulatory systems play major role in supply of nutrients to cells.
  • 18.  Respiratory system supply oxygen to body cells and remove carbon dioxide from body.  Kidneys are involved in excretion of waste products.  Hormones are to be synthesized and released from endocrine glands in approprite quantities.