Constipation is defined as having less than 3 bowel movements per week. It is caused by slow movement of stool through the colon due to factors like diet, lack of exercise, age, medications, and medical conditions. Symptoms include infrequent bowel movements, hard stools, and abdominal discomfort. Treatment begins with lifestyle and dietary changes, then uses laxatives if needed. There are several types of laxatives including bulk-forming, stool softeners, stimulant, and osmotic laxatives. Each works through different mechanisms to promote bowel movements and relieve constipation.
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
this presentation gives the knowledge about the decongestants are a type of medication that can provide short relief for a blocked nose ................
this presentation gives the knowledge about the decongestants are a type of medication that can provide short relief for a blocked nose ................
Constipation is a comdition which causes difficulty in ecretion of feaces, less than three bowel in a week. the drugs that are used to treat constipation are cathartics.
Diarrhoea is a condition of excretion of loose stool and water equal or more than three bowel movement in a day. it is of three types, acute, dysentry, chronic diarrrhoea. may caused by bacteria E.coli, and Rotavirus in children. drugs used to treat are called anti diarrhoeal drugs.
A brief information about the constipation- causes, pathogenesis and drugs used for treating the constipation - classification, mechanism of action, dosage and indications.
And a brief information about diarrhea - causes, pathogenesis and treatment of diarrhea with drugs and its classification, mechanism of action, dose and indications
this topic is essentially for GNM students. it contains all the information related to preparation and giving laxatives to patient whether in hospital settings or at home along with the nurses role. this topic gives important information to students in concise way regarding how to prepare the laxatives for patient and what precautions are to be taken during giving and after laxatives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. CONSTIPATION
• Constipation is a condition where there is
infrequent bowel movement, usually less than 3
stools per week.
• As the food moves down through the large
intestine, the colon absorbs water while forming
waste products or stool. Muscle contraction in
the colon push the stool towards rectum. By the
time the stool reaches rectum it is solid because
most of the water has been absorbed. The colon
muscle contraction are slow or sluggish causing
stool move through colon too slowly.
3. CAUSES:
Diet (Lack of fibers & liquids)
Lack of exercise
Age
Irregular bowel habits
Drug induced
Disease States/Conditions
Spasm of sigmoid colon
Dysfunction of myenteric plexus
4. SYMPTOMS OF CONSTIPATION
Infrequent defecation
Nausea
Vomiting
Anorexia
Feeling full quickly
Stools that are small, hard, and/or difficult to evacuate
Rectal bleeding
Weight loss (in chronic constipation)
5. Management of constipation
Beginning with advice on lifestyle (including
exercise and adequate hydration)
Dietary modification.
Consumption of plenty of fresh vegetables, fruits,
milk, and water.
Establishing regular bowel, eating and exercises
habits.
Where lifestyle changes and dietary modification
are insufficient, a laxative may be considered.
7. MECHANISM OF ACTION
All laxatives increase the water content of the faeces
by:
a) A hydrophilic or osmotic action, retaining water
and electrolytes in the intestinal
lumen—increase volume of colonic content and
make it easily propelled.
(b) Acting on intestinal mucosa, decrease net
absorption of water and electrolyte; intestinal transit
is enhanced indirectly by the fluid bulk.
(c) Increasing propulsive activity as primary action
—allowing less time for absorption of salt and water
as a secondary effect.
8. Laxatives modify the fluid dynamics of the mucosal cell
and may cause fluid accumulation in gut lumen by one or
more of following mechanisms:
(a)Inhibiting Na+K+ATPase of villous cells—impairing
electrolyte and water absorption.
(b)Stimulating adenylyl cyclase in crypt cells—increasing
water and electrolyte secretion.
(c)Enhancing PG synthesis in mucosa which increases
secretion.
(d)Increasing NO synthesis which enhances secretion and
inhibits non-propulsive contrations in colon.
(e) Structural injury to the absorbing intestinal mucosal
cells.
10. Bulk-forming laxatives
Bulk-forming laxatives are indigestible,
hydrophilic colloids that absorb water, forming a
bulky, emollient gel that distends the colon and
promotes peristalsis.
Common preparations include
Bran
Ispaghula
Methylcellulose and related compounds,
psyllium, or sterculia.
Bulk laxatives are of particular value in those with
small hard stools.
11. Bulk Forming Laxatives
Improve stool consistency and frequency with regular use
Ensure good fluid intake to prevent fecal impaction
Onset of action 2-3 days
Side Effects may include bloating, flatulence, distension
12. STOOL SOFTENERS
Docusates(Dioctyl sodium sulfosuccinate:DOSS)
It is an anionic detergent, softens the stools by net water
accumulation in the lumen by an action on the intestinal
mucosa. Dose: 100–400 mg/day; acts in 1–3 days.
Liquid paraffin
It is a viscous liquid mixture of petroleum hydrocarbons
that is pharmacologically inert.
Taken for 2–3 days, it softens stools and is said to lubricate
hard scybali by coating them.
Dose: 15–30 ml/day—oil as such or in emulsified form.
13. Stool Softeners
May be useful with anal fissures of haemorrhoids
Liquid paraffin is not recommended for treatment of
constipation
-risk of aspiration and lipid pneumonia
-long term use may result in depletion of Vit A, D, E, K
14. Stimulant laxatives
Stimulant laxatives (cathartics) induce bowel
movements through a number of mechanisms.
These include direct stimulation of the enteric
nervous system and colonic electrolyte and fluid
secretion.
Stimulant laxatives in current use include
Phenolphthalein 60–130 mg: LAXIL 130 mg tab.
To be taken at bedtime (tab. not to be chewed).
Bisacodyl 5–15 mg: DULCOLAX 5 mg tab; 10 mg
Senna
Castor oil
15. Stimulant Laxatives
Increase intestinal motility by stimulating colonic nerves
Useful with opioids
Onset of action 8-12 hours
Development of tolerance is reported to be uncommon
Generally considered 2nd
line therapy in elderly due to risk
of electrolyte disturbances
Other adverse effects include cramping, diarrhoea,
dehydration
16. Osmotic laxatives
Osmotic laxatives are soluble but non absorbable
compounds that result in increased stool liquidity due to
increase in fecal fluid.
saline laxatives such as magnesium hydroxide and
magnesium sulfate
poorly absorbed sugars such as lactulose or sorbitol,
and macrogols (PEG).
Non absorbable Sugars or Salts may be used for the
treatment of acute constipation or the prevention of
chronic constipation.
Magnesium oxide (milk of magnesia) is a commonly
used osmotic laxative. It should not be used for
prolonged periods in patients with renal insufficiency due
to risk of hypermagnesemia.
17. Osmotic Laxatives
Increase fecal water content
bowel distention
increased peristalsis
evacuation
Improving stool frequency
Onset of action – up to 48 hours
Metabolized by bacteria → flatulence
18. Lactulose It is a semisynthetic disaccharide of fructose
and lactose which is neither digested nor absorbed in the small
intestine—retains water.
Further, it is broken down in the colon by bacteria to osmotically
more active products.
In a dose of 10 g BD taken with plenty of water, it produces soft
formed stools in 1–3 days. Flatulence and flatus is common,
cramps occur in few. Some patients feel nauseated by its peculiar
sweet taste.
Onset of action: 48hrs
Dose: 15-30ml 8 hrly (10g/15ml)
Indication
Hepatic encephalopathy
Distal ulcerative colitis
19. Uses:
1.Functional constipation
2. Bedridden patients
3. To avoid straining at stools (hernia, cardiovascular
disease, eye surgery) and in perianal afflictions
(piles, fissure, anal surgery)
4. Preparation of bowel for surgery, colonoscopy,
abdominal X-ray
5. After certain anthelmintics
6. Food/Drug Poisoning
20. Adverse Effects:
1. Flairing of intestinal pathology, rupture of inflamed
appendix.
2. Fluid and electrolyte imbalance, especially
hypokalaemia.
3. Steatorrhoea, malabsorption syndrome.
4. Protein losing enteropathy.
5. Spastic colitis.
Contraindications:
1. A patient of undiagnosed abdominal pain, colic or
vomiting.
2. Organic (secondary) constipation due to stricture or
obstruction in bowel, hypothyroidism, hypercalcaemia,
malignancies and certain drugs.