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JAPANESE ENCEPHALITIS 
SUJATA MOHAPATRA
OVERVIEW 
• History 
• Geographical 
distribution 
• Epidemiology 
• Transmission 
• Pathogenesis 
• Clinical Signs 
• Diagnosis and 
Treatment 
• Prevention and Control 
• Nursing Actions
HISTORY 
• 1924: Great epidemic in Japan 
– 6,125 human cases; 3,797 deaths 
• 1935: Virus first isolated 
– Fatal human encephalitis case 
• 1938: Virus isolated from mosquito Culex 
tritaeniorhynchus 
• 1940 to 1978 
– Disease spread with epidemics in China, 
Korea, and India.
KEY FACTS 
In India 300 million 
population is at risk. 
Highest in U.P, Assam & 
Bihar. 
2010:- 5,167 cases with 679 
death. 
2011:- 7,838 cases with 
1,137 death.
EPIDEMIOLOGY
AGENT 
• Genus Flavivirus 
• Otherwise known as group B 
Arbovirus. 
• Single stranded, enveloped RNA 
virus. 
• Transmitted by Culicine 
mosquitoes.
Host & reservoir 
Reservoir/amplifying hosts 
• Pigs, bats, Ardeid (wading) 
birds 
Incidental hosts 
• Horses, humans, others
TRANSMISSION 
• Vector-borne & Enzootic cycle 
• Mosquitoes: Culex species: 
C.tritaeniorhynchus 
C. Vishnui
PATHOGENESIS 
Incubation Period 4 to 14 days.
CLINICAL FEATURES 
A Prodromal Stage 
An Acute encephalitic Stage 
Late stage & Sequelae
Prodermal Stage 
• Lasts for 1-6 days 
• Fever, Rigor 
• Headache 
• Gastrointestinal 
problems 
• Lethargy 
• Malaise
Acute encephalitic Stage 
• Convulsions 
• Altered sensorium, unconsciousness, 
coma 
• Tremors in fingers, tongue, eyelids and 
eyes. 
• Abnormal movements of limbs 
• Mask like face 
• Stiff Neck 
• Muscular Rigidity 
• Speech impairment
Late stage & Sequelae 
Characterized by the persistence of signs 
of CNS injury such as, 
• Mental impairment. 
• Increased deep Tendon reflexes 
• Epilepsy, Abnormal movements, 
Behaviour abnormalities. 
• Paresis motor neuron type. 
• speech impairment
Lethargy 
Sudden fever 
Headache Change in 
Vomiting and 
diarrhea 
Tremors or 
convulsions 
consciousness 
Irritability or 
restlessness 
Common symptoms of J.encephalitis
DIAGNOSIS 
• History 
• CSF analysis: CSF protein is moderately 
elevated. 
• Serological tests: These are to detect 
antibodies to viral antigens.(IgM) 
• ELISA
PREVENTION & CONTROL
Vaccination 
 Vaccination 
– Equine, swine, humans 
 Human- Inactivated vaccine (JE-VAX) 
 Available under UIP in 83 endemic districts of India. 
 Schedule- 1-3yr (1st dose-4wk-2nd dose) 
 Booster doses- every 3 yearly(upto10-15year) 
 Subcutaneous(0.5-1ml) 
TRAVELLERS- 0-7-28day(booster in 1 year & every 3 year)
Vector Control 
– Eliminate mosquito breeding areas 
– Adult and larvae control: ULV 
Insecticide & PPM. 
– Cover tightly all water containers, 
wells and water storage tanks. 
– Place of accommodation should have 
mosquito nets; use insecticides or coil 
incenses to repel mosquitoes. 
– Apply DEET-containing mosquito-repellents.
TREATMENT 
No anti viral drugs have been 
discovered against JE so far. 
Supportive treatment only 
Correction of Blood Sugar 
Suction-Oxygen 
IV Fluids & Mannitol 
IV Anti-Convulsant 
Inj. Paracetamol
Nursing Consideration 
• Intake-Output Charting. 
• Vital Sign Monitoring. 
• Strictly observe the client in Convulsion. 
AS CHN 
• Assess the immunization status. 
• Educate people regarding Vaccination. 
• Encourage people for adopting preventive 
measures. 
• Promote early diagnosis & treatment.
REFERENCE 
• Gulani K. K., Community health nursing,second 
edition,Delhi: Kumar publishing house,2012. 
• Park K, Preventive and social medicine, 21st edition, 
Jabalpur: M/s BanarasiDas Bhanot Publisher,2011. 
• Japanese encephalitis globally and in india-indian journal 
of public health vol.XXXXVIII no.2april-june 2004 
• Www.Google.Co.In 
• http://gkpdiv.up.nic.in 
• www.cdc.gov/ncidod/dvbid/jencephalitis/qa.htm 
• www.sumerdoc.blogspot.com 
• www.arbovirus.health.nsw.gov.au
SUMMERIZATION
OPEN DISCUSSION
THANK YOU

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Japanese encephalitis

  • 2. OVERVIEW • History • Geographical distribution • Epidemiology • Transmission • Pathogenesis • Clinical Signs • Diagnosis and Treatment • Prevention and Control • Nursing Actions
  • 3. HISTORY • 1924: Great epidemic in Japan – 6,125 human cases; 3,797 deaths • 1935: Virus first isolated – Fatal human encephalitis case • 1938: Virus isolated from mosquito Culex tritaeniorhynchus • 1940 to 1978 – Disease spread with epidemics in China, Korea, and India.
  • 4.
  • 5.
  • 6. KEY FACTS In India 300 million population is at risk. Highest in U.P, Assam & Bihar. 2010:- 5,167 cases with 679 death. 2011:- 7,838 cases with 1,137 death.
  • 8. AGENT • Genus Flavivirus • Otherwise known as group B Arbovirus. • Single stranded, enveloped RNA virus. • Transmitted by Culicine mosquitoes.
  • 9. Host & reservoir Reservoir/amplifying hosts • Pigs, bats, Ardeid (wading) birds Incidental hosts • Horses, humans, others
  • 10. TRANSMISSION • Vector-borne & Enzootic cycle • Mosquitoes: Culex species: C.tritaeniorhynchus C. Vishnui
  • 12. CLINICAL FEATURES A Prodromal Stage An Acute encephalitic Stage Late stage & Sequelae
  • 13. Prodermal Stage • Lasts for 1-6 days • Fever, Rigor • Headache • Gastrointestinal problems • Lethargy • Malaise
  • 14. Acute encephalitic Stage • Convulsions • Altered sensorium, unconsciousness, coma • Tremors in fingers, tongue, eyelids and eyes. • Abnormal movements of limbs • Mask like face • Stiff Neck • Muscular Rigidity • Speech impairment
  • 15. Late stage & Sequelae Characterized by the persistence of signs of CNS injury such as, • Mental impairment. • Increased deep Tendon reflexes • Epilepsy, Abnormal movements, Behaviour abnormalities. • Paresis motor neuron type. • speech impairment
  • 16. Lethargy Sudden fever Headache Change in Vomiting and diarrhea Tremors or convulsions consciousness Irritability or restlessness Common symptoms of J.encephalitis
  • 17. DIAGNOSIS • History • CSF analysis: CSF protein is moderately elevated. • Serological tests: These are to detect antibodies to viral antigens.(IgM) • ELISA
  • 19. Vaccination  Vaccination – Equine, swine, humans  Human- Inactivated vaccine (JE-VAX)  Available under UIP in 83 endemic districts of India.  Schedule- 1-3yr (1st dose-4wk-2nd dose)  Booster doses- every 3 yearly(upto10-15year)  Subcutaneous(0.5-1ml) TRAVELLERS- 0-7-28day(booster in 1 year & every 3 year)
  • 20. Vector Control – Eliminate mosquito breeding areas – Adult and larvae control: ULV Insecticide & PPM. – Cover tightly all water containers, wells and water storage tanks. – Place of accommodation should have mosquito nets; use insecticides or coil incenses to repel mosquitoes. – Apply DEET-containing mosquito-repellents.
  • 21. TREATMENT No anti viral drugs have been discovered against JE so far. Supportive treatment only Correction of Blood Sugar Suction-Oxygen IV Fluids & Mannitol IV Anti-Convulsant Inj. Paracetamol
  • 22. Nursing Consideration • Intake-Output Charting. • Vital Sign Monitoring. • Strictly observe the client in Convulsion. AS CHN • Assess the immunization status. • Educate people regarding Vaccination. • Encourage people for adopting preventive measures. • Promote early diagnosis & treatment.
  • 23. REFERENCE • Gulani K. K., Community health nursing,second edition,Delhi: Kumar publishing house,2012. • Park K, Preventive and social medicine, 21st edition, Jabalpur: M/s BanarasiDas Bhanot Publisher,2011. • Japanese encephalitis globally and in india-indian journal of public health vol.XXXXVIII no.2april-june 2004 • Www.Google.Co.In • http://gkpdiv.up.nic.in • www.cdc.gov/ncidod/dvbid/jencephalitis/qa.htm • www.sumerdoc.blogspot.com • www.arbovirus.health.nsw.gov.au