1. Japanese encephalitis is a viral disease transmitted through mosquito bites that causes brain swelling and inflammation.
2. The virus has a zoonotic transmission cycle between mosquitoes, pigs, and water birds, though humans are accidental hosts.
3. Symptoms range from fever and headache to meningitis or encephalitis. There is no specific treatment, so care is supportive.
This ppt contains all the information about Revised NationalTuberculosis Control programme (RNTCP) It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved) and everyone who is interested in in knowing about it.
National Vector Borne Disease Control Programme (NVBDCP)Vivek Varat
The National Vector Borne Disease Control Programme (NVBDCP) is an umbrella programme for prevention and control of malaria and other vector borne diseases. Under the programme, it is ensured that the disadvantaged and marginalised sections benefit from the delivery of services so that the desired National Health Policy and Rural Health Mission goals are achieved. The Directorate of NVBDCP under the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, is the nodal agency responsible for planning, coordination, implementation, monitoring and evaluation of NVBDCP programme at all levels.
This ppt contains all the information about Revised NationalTuberculosis Control programme (RNTCP) It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved) and everyone who is interested in in knowing about it.
National Vector Borne Disease Control Programme (NVBDCP)Vivek Varat
The National Vector Borne Disease Control Programme (NVBDCP) is an umbrella programme for prevention and control of malaria and other vector borne diseases. Under the programme, it is ensured that the disadvantaged and marginalised sections benefit from the delivery of services so that the desired National Health Policy and Rural Health Mission goals are achieved. The Directorate of NVBDCP under the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, is the nodal agency responsible for planning, coordination, implementation, monitoring and evaluation of NVBDCP programme at all levels.
A decentralized system of disease surveillance for timely and effective public health action with a focus on functional integration of surveillance components of various vertical programmes.
ndia is one of the developing countries who have national cancer control programme (NCCP). We started way back in 1975 and the plan has been revised three times. The first revision was in 1984, second one in 1991 and third one 2004.
National Leprosy Eradication Programme (NLEP)Kavya .
Chronic infectious disease caused by Mycobacterium leprae.
It usually affects the skin and peripheral nerves
Long incubation period generally 5-7 years.
Classified as paucibacillary or multibacillary
permanent disability
Timely diagnosis and treatment of cases
A decentralized system of disease surveillance for timely and effective public health action with a focus on functional integration of surveillance components of various vertical programmes.
ndia is one of the developing countries who have national cancer control programme (NCCP). We started way back in 1975 and the plan has been revised three times. The first revision was in 1984, second one in 1991 and third one 2004.
National Leprosy Eradication Programme (NLEP)Kavya .
Chronic infectious disease caused by Mycobacterium leprae.
It usually affects the skin and peripheral nerves
Long incubation period generally 5-7 years.
Classified as paucibacillary or multibacillary
permanent disability
Timely diagnosis and treatment of cases
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. LESSON OBJECTIVE
• At the end of the class the learner
should be able to:
1. Explain in detail the programme to
prevent Japanese B Encephalitis
2. Explain It’s focus and implementation
strategies
3. Enumerate the preventive measures
3. WHAT IS JAPANESE ENCEPHALITIS?
• Japanese Encephalitis is a viral disease
• It is transmitted by infective bites of
female mosquitoes mainly belonging to
Culex tritaeniorhynchus, Culex vishnui
and Culex pseudovishnui group.
However, some other mosquito species
also play a role in transmission under
specific conditions
4. • JE virus is primarily zoonotic in
its natural cycle and man is an
accidental host.
• JE virus is neurotorpic and
arbovirus and primarily affects
central nervous system
5. WHAT ARE SIGN AND
SYMPTOMS OF JE?
• JE virus infection presents classical symptoms
similar to any other virus causing encephalitis
• JE virus infection may result in febrile illness of
variable severity associated with neurological
symptoms ranging from headache to meningitis
or encephalitis. Symptoms can include
headache, fever, meningeal signs, stupor,
disorientation, coma, tremors, paralysis
(generalized), hypertonia, loss of coordination,
6. • Prodromal stage may be abrupt (1-6
hours), acute (6-24 hours) or more
commonly subacute (2-5 days)
• In acute encephalitic stage, symptoms
noted in prodromal phase convulsions,
alteration of sensorium, behavioural
changes, motor paralysis and
involuntary movement supervene and
focal neurological deficit is common.
Usually lasts for a week but may prolong
due to complications.
7. • Amongst patients who survive, some
lead to full recovery through steady
improvement and some suffer with
stabilization of neurological deficit.
Convalescent phase is prolonged and
vary from a few weeks to several
months.
• Clinically it is difficult to differentiate
between JE and other viral encephalitis
8. • JE virus infection presents
classical symptoms similar to any
other virus causing encephalitis
9. HOW JAPANESE ENCEPHALITIS
IS TRANSMITTED?
• Japanese encephalitis is a vector
borne disease.
• Several species of mosquitoes
are capable of transmitting JE
virus.
10. • JE is a zoonotic infection. Natural hosts
of JE virus include water birds of
Ardeidae family (mainly pond herons
and cattle egrets). Pigs play an
important role in the natural cycle and
serve as an amplifier host since they
allow manifold virus multiplication
without suffering from disease and
maintain prolonged viraemia.
11. • Due to prolonged viraemia,
mosquitoes get opportunity to pick
up infection from pigs easily.
• Man is a dead end in transmission
cycle due to low and short-lived
viraemia. Mosquitoes do not get
infection from JE patient.
12. JAPANESE ENCEPHALITIS
VECTORS IN INDIA
• Culicine mosquitoes mainly Culex
vishnui group (Culex tritaeniorhynchus,
Culex vishnui and Culex
pseudovishnui) are the chief vectors of
JE in different parts of India.
13. LIFE CYCLE
• Life cycle consists of egg, four instars of
larvae, pupa and adult. The whole cycle takes
more than a month, however, duration
depends on temperature and other ecological
conditions.
• Culex vishnui subgroup is very common,
widespread and breed in water with
luxuriant vegetation mainly in paddy fields
and the abundance is related to rice
cultivation, shallow ditches and pools.
14. • These vectors are primarily outdoor
resting in vegetation and other shaded
places but in summer may also rest in
indoors.
• They are in principally cattle feeders,
though human and pig feeding are also
recorded in some areas.
15. • Female mosquitoes get infected after
feeding on a viraemic host andafter 9-12
days incubation period, they can
transmit the virus to other hosts
16. JE IN MAN
• The incubation in period in man is 5-
15 days. The course of disease in
man may be divided into three
stages
• PRODROMAL STAGE
• ENCEPHALTIC STAGE
• LATE STAGE & SEQUELAE
17. PRODROMAL STAGE
• The onset of illness is usually acute
and is marked by fever, headache,
GI distrubance, lethargy and
malaise. The duration of this stage
usally 1-6 days
18. ACUTE LYMPHATIC STAGE
• Fever is usually high (38 -40.7 C). The
prominent features are fever, nuchal
rigidity, focal CNS symptoms,
convulsions, signs of raised intra cranial
pressure, difficulty of
speech,dystonia,ocular palsies,
hemiplwgia, quadriplegia, extra
pyramidal signs, altered sensorium
progressing to coma
19. LATE STAGE & SEQUELAE
• This stage begins when active
inflammation is at end. The
temperature and ESR are normal.
Neurological signs become
stationary or tend to improve.
Convalescence may be prolonged
with neurological defects.
20. HOW JE IS DIAGNOSED?
• Clinical:
cases present signs and symptoms similar to
encephalitis of viral origin and cannot be
distinguished for confirmation.
However, JE can be suspected as the cause of
encephalitis as a febrile illness of variable
severity associated with neurological symptoms
ranging from headache to meningitis or
encephalitis. Symptoms can include headache,
fever, meningeal signs, stupor, disorientation,
coma, tremors, paralysis (generalized),
hypertonia , loss of coordination.
21. Laboratory:
• Several laboratory tests are available for JE
virus detection which include;
•
Antibody detection: Heamagglutination
Inhibition Test (HI), Compliment Fixation
Test (CF), Enzyme Linked Immuno-Sorbant
Assay (ELISA) for IgG (paired) and IgM
(MAC) antibodies, etc.
• Antigen Detection: RPHA, IFA,
Immunoperoxidase etc.
22. Clinical Suspect
• Febrile illness of variable severity
associated with neurological symptoms
ranging from headache to meningitis or
encephalitis.
• Symptoms can include headache, fever,
meningeal signs, stupor, disorientation,
coma, tremors, paralysis (generalized),
hypertonia , loss of coordination.
23. CONFIRMED
• A suspect case with confirmed
laboratory result : JE IgM in CSF or 4 fold
or greater rise in paired sera (acute &
Convalescent) through IgM/IgG ELISA,
HI, Neutralisation test or detection of
virus, antigen or genome in tissue,
blood or other body fluid by immuno-
chemistry, immunoflourescence
24. TREATMENT OF JAPANESE
ENCEPHALITIS
• There is no specific anti-viral medicine
available against JE virus. The cases are
managed symptomatologically.
• Clinical management of JE is supportive
and in the acute phase is directed at
maintaining fluid and electrolyte balance
and control of convulsions, if present.
Maintenance of airway is crucial.
26. PREVENTION AND CONTROL
MEASURES
The preventive measures are directed at
reducing the vector density and in taking
personal protection against mosquito bites
using insecticide treated mosquito nets. The
reduction in mosquito breeding requires
eco-management, as the role of insecticides
is limited. Piggeries may be kept away (4-5
kms) from human dwellings
27. VACCINATION
• Currently three types of JE vaccines are
used
• MOUSE BRAIN DERIVED –PURIFIED &
INACTIVATED VACCINE
• CELL CULTURED DERIVED INACTIVATED
JE VACCINE
• CELL CULTURED DERIVED LIVE
ATTENUATED VACCINE
28. VECTOR CONTROL
• The vector mosquitoes of JE are widely
scattered and are not easily amenable
to control
• The effective way to control is through
ground or Ariel fogging with ultra low
volume of Malathion, Fenithrothion
29. • All villages reporting should be
brought under indoor residual
spray
• The spraying should cover the
vegetation around the houses,
breeding sites and animal
shelters in affected villages
30. • Uninfected villages falling within 2 to 3
km radius also receive spraying as
preventive measure
• Villages within the proximity of infected
villages should be kept under
surveillance.
• The use of mosquito net should be
advocated
32. CASE DEFINITION as follows
• Acute onset of fever, not more than 5-7
days duration
• Change in mental status with or without
–new onset of seizures (excluding febrile
seizures)
• Other early clinical findings – irritability,
somnolence or abnormal behaviour
greater than that seen with usual febrile
illness
33. CASE CLASSIFICATION
• FOR LAB CONFIRMED CASE:
• A suspected case with any of the
following markers:
• Presence of IgG abtibody titre in paired
sera
• Virus isolation from brain tissue
• Antigen detection by
immunofluroscence
• Nucleic acid detectition by PCR
34. PROBABLE CASES
• Suspected case in close geographic
and temporal relationship to a lab
confirmed case of AES (Acute
Encephalitic Syndrome) in an out
break
35. AES (due to other agent)
• A suspected case in which
diagnostic testing is performed and
an aetiological agent other than
JE/AES is suspected
36. MANAGEMENT
• Management of AES is essentially
symptomatic. To reduce severe
morbidity and mortality it is
important to identify early warning
signs and patients to referral center.
37. TREATMENT OF SPECIFIC CASE
• Meningitis due to other causes have
to be treated following specific
treatment protocols.
39. REFERENCES
• 1.Park’s Textbook of Preventive & Social
Medicine, Banarsidas Bhanot publishers,22
Ed
• 2. Basawanthappa B.T, Community Health
Nursing, Jayapee publications
• 3. Neelam Kumari, Text book of Community
Health Nursing, S. Vikas Publisher, First Edn
• 4. Rao.B Sridhar, Book of Community Health
Nursing,AITBS publisher, New Delhi