Type 3 hypersensitivity, also known as immune complex-mediated hypersensitivity, occurs when immune complexes are not adequately cleared from the bloodstream and deposit in tissues. This can cause inflammation in various organs like the skin, kidneys, and joints. The symptoms include fever, chills, and arthritis. Diseases associated with type 3 hypersensitivity include systemic lupus erythematosus and glomerulonephritis. Treatment focuses on controlling symptoms with steroids, immunosuppressants, or other drugs depending on severity.

1. HYPERSENSITIVITY
3
GROUP NINE(9)

2. CONTENT
• What is hypersensitivity type 3
• Causes of hypersensitivity three(3)
• Mode of work
• Symptoms of hypersensitivity 3
• Treatment of hypersensitivity 3
• Risk factors of hypersensitivity 3
• Disease associated with hypersensitivity
• Diagnosis of hypersensitivity 3
• References

3. WHAT IS HYPERSENSITIVITY 3
Type 3 hypersensitivity occurs when there is accumulation of
immune complexes that have not been adequately cleared by
innate immune cells, giving rise to an inflammatory.
These complexes travel through the blood stream and get
deposited in various organs.
Hence this can occur in many parts of the body. Generally,
common sites of deposition include:
1. Skin
2. Kidney
3. Joints

4. TYPE III HYPERSENSITIVITY:
IMMUNE COMPLEX-MEDIATED CYTOTOXICITY
• Caused by immune complex deposition in tissues
–Small amounts cleared by phagocytic cells
–Activates complement which attracts neutrophils and
stimulates Mast cell degranulation
–Depending on location, reaction can be localized or
systemic

5. MODE OF ACTION
•The type 3 reaction is induce by antigen-
antibody complex. This is as a result of various
biochemical mechanisms, this result in tissue
damage in the body.

6. SYMPTOMS
Fever
Chills
Arthritis
Rashes

7. RISK FACTORS
• Depending on the different manifestation of different type
3 diseases, there are different risk factors as well.
• There some gender differences between diseases of type 3.
disease are more common in females such as rheumatoid
arthritis.
• NB; ethnicity and geographical location can have impact on
the disease cases.

8. TREATMENT
• There is no cure for this disease, the treatment aims at symptom
control only.
• Because of the pathogenesis of these diseases are antibody in origin,
a lot of treatment options are aimed at that.
• Depending on the severity of the hypersensitivity reaction, different
treatment approaches are applied, including the following
• Steroids
• Interferon
• Cyclosporin
• cyclophosphamide

9. DISEASES ASSOCIATED WITH
HYPERSENSITIVITY 3
Systemic lupus erythematosus ( an inflammatory disorder of
connective tissue)

10. RHEUMATOID ARTHRITIS

11. GLOMERULONEPHRITIS
• Inflammation of the capillaries in the kidney

12. HOW IT CAN BE DIAGNOSED
Depending on the different type of diseases, some general
investigations may be necessary. Basic routine investigations may
include;
Blood function test
Liver function test
Thyroid function test
Kidney function test

14. REFERENCE
Braunwald E et al. Harrison’s principles of internal medicine. 15th
ed. New York; McGraw-Hill; 2001
Cotran, Kumar, Collins. Robbins Pathologic Basis of Disease. 6th
ed. WB Saunders Company. New York. 1999
Davidson A, Diamond B: Autoimmune diseases. N Engl J Med
2001 Aug 2; 345(5):340-50

15. MEMBERS
• Gyile yanume marcellinus UE20016517
• Addae Emmanuel UE20012317
• Akpor Daniel UE20013117
• Kudzordzi prince-Charles UE20017117
• Asare Elizabeth UE20013917