This document provides an overview of bone histology. It defines bone as a mineralized connective tissue composed of bone matrix and three cell types: osteoblasts, osteocytes, and osteoclasts. It describes the microscopic structure of compact and spongy bone, including osteons, central canals, lamellae, and trabeculae. It explains the functions of osteoblasts in bone formation, osteoclasts in bone resorption, and osteocytes in bone maintenance. Finally, it discusses the periosteum and endosteum, which cover the external and internal bone surfaces and provide nutrition and new osteoblasts.
a brief ppt description about cartilage which may be usefull for teaching for first year mbbs, bds and paramedical students, hope it is helpfull to everyone
Cartilage is a resilient and smooth elastic connective tissue, a rubber-like padding that covers and protects the ends of long bones at the joints, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components.
Histology
Junqueira’s Basic Histology Text and Atlas, 15th Ed
The presentation include general definition of bone and it's functions. Also, describe the chemical composition of bone and then specifically describe alveolar process.
Nervous System is a uniquely designed organ system of our body. This presentation is highlighting over the cellular configuration of this system. Neurons & Neuroglia are the two main players of the system. Neuron is the structural & functional unit of the system, while, Neuroglia are the supporting elements. At the end of this presentation, the young learner would be able to recognize different cell types of the Nervous system & their exclusive function.
a brief ppt description about cartilage which may be usefull for teaching for first year mbbs, bds and paramedical students, hope it is helpfull to everyone
Cartilage is a resilient and smooth elastic connective tissue, a rubber-like padding that covers and protects the ends of long bones at the joints, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components.
Histology
Junqueira’s Basic Histology Text and Atlas, 15th Ed
The presentation include general definition of bone and it's functions. Also, describe the chemical composition of bone and then specifically describe alveolar process.
Nervous System is a uniquely designed organ system of our body. This presentation is highlighting over the cellular configuration of this system. Neurons & Neuroglia are the two main players of the system. Neuron is the structural & functional unit of the system, while, Neuroglia are the supporting elements. At the end of this presentation, the young learner would be able to recognize different cell types of the Nervous system & their exclusive function.
Bone tissue is the major structural and supportive connective tissue of the body. Osseous tissue forms the rigid part of the bones that make up the skeletal system.
Do you know what is a cerclage cable? During hip replacement and treatment of associated peri-prosthetic fractures, it is often necessary to hold the bone or fragments of bone together to create a stable environment for healing to occur. This is typically done with metal wires or cables using a technique called Cerclage. A cerclage wire or cable is wound around a bone or bony fragments to hold them together to allow them to heal.
in this pdf you will know about one of the most important structure in the human body its bone we will know about its origin , types , function and other things
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Objective of The Lecture
• To know about definition of the bone.
• To master the basic structure of the
bone.
• To know about bone matrix and bone
cells.
• Illustrate and differentiate the three
type of bone cells.
• To know about the periosteum &
endosteum.
3. Bone
• Bone is a dense,
semirigid, porous,
calcified connective
tissue forming the
major portion of the
skeleton.
• It consists of a dense
organic matrix and an
inorganic, mineral
component.
4. Bone
• Bone is a specialized
connective tissue composed
of intercellular calcified
material, the bone matrix,
and three cell types:
osteocytes, osteoblasts and
osteoclasts
• All bones are lined on both
internal and external
surfaces by layers of tissue
containing osteogenic cells
endosteum on the internal
surface and periosteum on
the external surface.
5. Bone Functions
• Protects vital organs
• Supports soft tissue
• Movement
• Mineral storage
• Blood cell production
6. Microscopic structure
of compact bone
• The structural unit of
Compact bone is the
osteon,or haversian
system.
Each osteon
• Is an elongated cylinder
• Oriented parallel to the
• Long axis of the bone.
7. Microscopic structure
of compact bone
Osteon System:
• A central (Haversian)
canal with concentric
rings (lamellae) of bone
matrix running
lengthwise.
• Very strong!
8. Microscopic structure
of compact bone
• Central, or haversian
canal carries blood
vessels and nerves to all
areas of the bone.
• Canaliculi tiny canals that
radiate outward from the
central canals to each
lacunae space.
• Volkmann’s Canals:
canals that run at right
angles to the central
canals and perforate the
shaft of the bone.
13. Spongy Bone
• Spongy bone contains
trabeculae and spicules
giving it a honeycomb
appearance.
• Trabeculae: are
irregularly arranged and
contain lamellae and
osteocytes, but contain
no osteons as they
receive nutrients from
the marrow tissue.
15. Bone Matrix
• 25% Water
• 25% Protein or organic
matrix
– 95% Collagen Fibers
– 5% Chondroitin Sulfate
• 50% Crystalized Mineral
Salts Hydroxyapatite
(Calcium Phosphate) Other
substances: Lead, Gold,
Strontium, Plutonium, etc.
• Combination provides
strength and rigidity
– Laid down by osteoblasts
16. Bone Matrix
• If mineral removed, bone is too bendable
• If collagen removed, bone is too brittle
17. Bone Cells
1. Osteoblasts: Bone
generating cells
“B” means building
2. Osteocytes: Mature
bone cells, spider
shaped and maintain
bone tissue
3. Osteoclasts: Bone
destroying cells
“C” means chewing
18. Osteoblasts
• Osteoblasts are
responsible for the
synthesis of the organic
components of bone
matrix (type I collagen,
proteoglycans, and
glycoproteins).
• Osteoblasts depends on
deposition of the
inorganic components
of bone.
19. Osteoblasts
• Osteoblasts are exclusively
located at the surfaces of
bone tissue, side by side, in
a way that resembles simple
epithelium.
• When they are actively
engaged in matrix synthesis,
osteoblasts have a cuboidal
to columnar shape and
basophilic cytoplasm.
• When their synthesizing
activity declines, they
flatten, and cytoplasmic
basophilia declines.
21. Osteocytes
• Osteocytes, which
derive from osteoblasts,
lie in the lacunae
situated between
lamellae of matrix.
• Only one osteocyte is
found in each lacuna.
• Lacunae: spaces
occupied by osteocyte
cell body
24. Osteoclasts
• Osteoclasts are very large
and branched motile
cells.
• Dilated portions of the
cell body contain from 5
to 50 (or more) nuclei.
• Osteoclasts are derived
from the mononucleated
cells; (engulf bony
material).
• Active osteoblasts
stimulate osteoclast
activity.
25. Osteoclasts
Resorption of bone
• Ruffled border: where
cell membrane borders
bone and resorption is
taking place.
• H ions pumped across
membrane, acid forms,
eats away bone.
• Release enzymes that
digest the bone.
30. Periosteum
• It consists of an outer
layer of collagen fibers
and fibroblasts.
• Bundles of periosteal
collagen fibers, called
Sharpey's fibers,
penetrate the bone
matrix, binding the
periosteum to bone.
32. Endosteum
• It lines all internal cavities
within the bone and is
composed of a single
layer of flattened
osteoprogenitor cells and
a very small amount of
connective tissue.
• The endosteum is
therefore considerably
thinner than the
periosteum.
33. Periosteum & Endosteum
• The principal functions
of periosteum and
endosteum are
nutrition of osseous
tissue and provision of a
continuous supply of
new osteoblasts for
repair or growth of
bone.