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CARTILAGE
Prepared By:
Bikram Adhikari
Roll no.: 03
Introduction
 Cartilage is a specialized form of connective
tissue
 Mesodermal in origin
 Composition of cartilage :
 Cellular component:
 Chondrocytes
 Chondroblast and
 Composition of cartilage(contd..)
 Extracellular matrix
 Fibers:
 collagen fibres,
 elastic fibres
 Ground substance:
 Glycosaminoglyans (GAG)
 Chondriotin sulphate,
 Keratan sulphate,
 Hyaluronic acid
 Avascular
 No lymphatics vessels and nerve
 Perichondrium
 layer of dense connective tissue
 2 layers:
 Chondrogenic layer (inner)
 Fibrous layer (outer)
Functions of Cartilage:
 To bear mechanical stresses without permanent
distortion.
 Cartilage is a shock-absorbtion
 Provide Sliding area for joints - facilitates bone
movements.
 Development and growth of long bones both before
and after birth.
Types Of Cartilage
 3 types:
1. Hyaline cartilage
2. Yellow Elastic cartilage
3. White Fibro cartilage
1.Hyaline Cartilage
 Fresh hyaline cartilage is
bluish-white and
translucent
 Chondrocytes
 have an elliptic or round
 Cell are arranged in
group: (isogenous group
or cell nest)
Matrix consist:
 Type II Collagen fiber (basophilic)
 Chondroitin 4-sulfate
 Keratan sulfate
 Hyaluronidase
 Chondronectin
Hyaline Cartilage (contd..)
 Territorial matrix (lacunar capsule)
 Inter-territorial matrix
Examples of Hyaline Cartilage:
 Articular cartilage
 Epiphyseal plate
 Larynx: Cricoid and
artenoid cartilages
Costal
cartilageTrachea, bronchi and bronchioles
Fetal cartilage
 Fresh elastic cartilage has a yellowish color
2.Yellow elastic Cartilage
Yellow elastic Cartilage(contd..)
 Chondrocytes:
 Large, scattered
 Matrix
 Elastic fibres+ collagen type II
 Pericondrium present
Examples of Yellow elastic cartilage
 Auricle of the ear,
 External auditory canals,
 Epiglottis, and
 Cuneiform cartilage
 Apical part of arytenoid
cartilage
3. White fibro Cartilage
 No identifiable Perichondrium
 Chondrocytes: arranged in linear group separated by
collagen fibers
 Matrix: Collagen I type + collagen II type collagen
Pubis symphysisIntervertebral
disc
Manubriosternal joint
Intervetebral disc
Examples: White fibro Cartilage:
References Singh Indirbir. 2011. Pages 93-97 in Text book of Human
Histology. 6th
edition. Jaypee Brothers medical publishers.
New delhi
 Eroschenko Victor P. Pages 65-72 in Difiore’s Atlas of
Histology.10th
edition. Lippincott Williams & Wilkins. 351 West
Camden Street
Baltimore.
 Junqueira luis Caralos, Carneiro Jose. Chapter 7 in Basic
histology text and atlas,11th
edition, McGraw-Hill’s.
 Graaff Kent Van De. Pages 141, 158,164,181,608, in Human
Anatomy. 6th
edition. McGraws-Hill’s.
 Standring Susan. Page 83-87, 742. Gray’s Anatomy.39th
edition. Edinburgh: Churchill Livingstone
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