This document provides information on epithelial tissue. It begins by defining epithelium as sheets of cells that cover outer surfaces of the body and line internal organs. Epithelial tissue is classified based on the number of cell layers and cell shapes. There are simple, stratified, pseudostratified and transitional epithelia. The document also describes basement membranes, intercellular junctions, and specializations of the free cell surface like microvilli, cilia and stereocilia. Glandular epithelia are discussed, including exocrine and endocrine glands and their classifications.
Connective tissue is the tissue that connects or separates, and supports all the other types of tissues in the body. Like all tissue types, it consists of cells surrounded by a compartment of fluid called the extracellular matrix (ECM). However connective tissue differs from other types in that its cells are loosely, rather than tightly, packed within the ECM.
Connective tissue is the tissue that connects or separates, and supports all the other types of tissues in the body. Like all tissue types, it consists of cells surrounded by a compartment of fluid called the extracellular matrix (ECM). However connective tissue differs from other types in that its cells are loosely, rather than tightly, packed within the ECM.
epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
detail notes on connective tissue..
Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesoderm. Connective tissue is found in between other tissues everywhere in the body, including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain and spinal cord are composed of connective tissue.
All connective tissue consists of three main components: fibers (elastic and collagenous fibers), ground substance and cells. Not all authorities include blood or lymph as connective tissue because they lack the fiber component. All are immersed in the body water.
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epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
detail notes on connective tissue..
Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesoderm. Connective tissue is found in between other tissues everywhere in the body, including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain and spinal cord are composed of connective tissue.
All connective tissue consists of three main components: fibers (elastic and collagenous fibers), ground substance and cells. Not all authorities include blood or lymph as connective tissue because they lack the fiber component. All are immersed in the body water.
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introduction to tissues-human body is made up of 4 basic tissues- connective tissues, epithelium tissue, nervous tissue, muscular tissue--biological tissues is a collection of interconnected cells that perform a similar function and an embryological origin with similar structure , types of tissues , microscopic diagram, diagrams of tissues, epithelial tissue and types, connective tissue , its components and types
Types of tissues with characteristic's and distribution regions
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
3. EPITHELIUM
• Basic tissue of the body
• Cells arranged as continuous sheets
• Single or multiple layers
• Covers the outer surface of the body or line the
luminal surface of tubular structures and cavities of
the body
5/28/2019 3
5. CHARACTERISTICS OF EPITHELIAL
TISSUE
• Epithelium consists of tightly packed cells- very
cellular with little intercellular space 20um
• Usually avascular- They lack a blood supply, instead
they receive nutrients by diffusion from capillaries in ct
• Epithelium readily divide, so they are continually
replaced = rapid healing- high capability to regenerate
5/28/2019 5
6. • Cells rest on basement membrane
• Cells shows polarity
• Cells may display surface
modification
• Supplied by nerves
• Secretory portion of glands and
cells lining the ducts are epithelial
in nature (glands are epithelial in
origin)5/28/2019 6
11. SIMPLE
SQUAMOUS
• Single layer of flattened cells
• Functions include diffusion,
filtration, and secretion
Locations include:
• air sacs of lungs (alveoli)
• lining of capillaries and the walls
of blood vessels, glomerulus of
kidneys, endocardium, internal
5/28/2019 11
12. S I M P L E
S Q UA M O U S
• Polygonal outlines
• Height less as compared with
width
• Thin layer
• Nucleus –oval/flat, Nuclei
forms bulging of cell surface
• Endothelium
• Mesothelium
5/28/2019 12
14. SIMPLE CUBOIDAL EPITHELIUM
• Height is same as that
of width
• Round nuclei
• Sectional view-
cuboidal in shape
• Surface view-
hexagonal in shape
5/28/2019 14
15. SIMPLE
CUBOIDAL
• Single layer of cube-shaped
cells
• Functions include secretion
and absorption
• Locations include
• Follicles of thyroid
• the lining and the ducts of
some glands
• Surface of ovary
• tubules within kidneys
5/28/2019 15
16. SIMPLE
COLUMNAR• Cells –taller
• Elongated nuclei-located at the
lower half
• All nuclei at same level
• Vertical section- rectangular ,
surface view- polygonal
• Cilia/ microvilli
5/28/2019 16
17. SIMPLE
COLUMNAR• Location: stomach & large
intestine, Brush border- gall
bladder, ciliated columnar
epithelium-respiratory tract,
uterus, central canal of spinal
cord, ventricles of brain
• Function: secretion, absorption
Goblet cells
5/28/2019 17
18. STRATIFIED EPITHELIUM
STRATIFIED SQUAMOUS
(NON-KERATINIZED)
• Many layers
• Basal layer-
cuboidal/round,
intermediate- polyhedral,
superficial layer- flattened
• Location- lining oral cavity,
tongue, part of epiglottis,
oesophagus , vagina
• Function- protection of
STRATIFIED SQUAMOUS
(KERATINIZED)
• Dead, dehydrated, non-
nucleated like scales
• Location- skin
• Function- protection,
prevents absorption of
water, prevents
dehydration of underlying
tissues
5/28/2019 18
21. STRATIFIED CUBOIDAL
• Many layers
• Ducts of sweat glands
• Provides passage to the
secretion and act as a
barrier
STRATIFIED COLUMNAR
• Many layers
• Epithelium lining large
ducts of glands
• Fornix of conjunctiva,
urethra
• Provides passage to the
secretion and acts as
barrier
5/28/2019 21
22. PSEUDOSTRATIFIED EPITHELIUM
• Not a true stratified epithelium
• Appears to be stratified
• All cells are attached to the basement membrane but
are of different heights
• hence not all reach the apical surface
• Nuclei at different levels
• Ciliated/non-ciliated , goblet cells
5/28/2019 22
23. Location :
• Non- ciliated – auditory tube, ductus deferens, male urethra
• Ciliated –trachea & large bronchi
• Pseu stra col epi with sterocilia- epididymis
Function:
• Tall columnary- Secretory
• Short, basal cells are stem cells- replace tall cells
• Cilia help in clearance of mucous
• Stereocilia help in absorption
5/28/2019 23
27. TRANSITIONAL EPITHELIUM
• Mutilayered 4-6 cells thick
• Differs from stratified squamous epithelium , surface
cells are not squamous
• Deepest cells- columnar/ cuboidal
• Middle layer-polyhedral/pear-shaped
• Surface layer- umbrella shaped
• Can be stretched without losing heir integrity-
becomes thinner and flattened
5/28/2019 27
28. • Location :
Renal pelvis, calyces, ureter, urinary bladder, part of
urethra
Urothelium
• Function :
The presence of occluding junctions and
intramembranous plaques forms an effective barrier,
prevents absorption of toxic substances of urine
Distention
5/28/2019 28
30. BASEMENT MEMBRANE
• thin supporting layer placed between basal surface of
epithelium and under line connective tissue
• Epithelium cells rest on the basement membrane
• Under EM – appears by layers , basal lamina and
reticular lamina
Functions: provides adhesion on one side to epithelial
cells , other side connective tissue ,
• Act as barrier of diffusion
• Influence regeneration of peripheral nerves
5/28/2019 30
32. SPECIALIZATION OF THE FREE
SURFACE OF THE CELL
a. Microvilli
b. Stereocilia
c. Cilia
5/28/2019 32
33. Cilia :
• Hair like projections
• Free part of the each cilia- shaft
• Region of attachment of shaft to cell- base
• Outer covering- extension of cell membrane, inner
core- microtubules
• Functions : wave-like movements on the surface of
tracheal and bronchial epithelium help to move the
mucous in one direction , movement of ova in oviduct
•
5/28/2019 33
34. Micro villi:
• Fine vertical striations / finger like projections
• Closely packed
• 1-2 um , 75-90 um
• Plasma membrane/ cytoplasmic core/ microfilaments/
actin filaments
• Brush border
• Function : non-motile process, increase the surface
area, active absorption
• Location : intestine, proximal convoluted tubule of
kidney5/28/2019 34
37. • Glands – specialized secretory cells
• Epithelial in origin
• Unicellular or multicellular
• Exocrine glands : epithelial layer
invaginates in deeper tissue to
form a diverticulum. The proximal
end of this forms duct while distal
end forms secretory units. These
type of glands remain in contact
with surface epithelium by the
duct and pour their secretions on
its surface5/28/2019 37
38. • Endocrine glands: some glands
lose contact with the epithelial
surface. They pour their
secretions directly in the blood.
(internally secreting glands/
duct less glands)
• Paracrine : similar to endocrine,
but secretion diffuses directly
into target cells eg : bronchus
5/28/2019 38