Connective tissue is the tissue that connects or separates, and supports all the other types of tissues in the body. Like all tissue types, it consists of cells surrounded by a compartment of fluid called the extracellular matrix (ECM). However connective tissue differs from other types in that its cells are loosely, rather than tightly, packed within the ECM.
epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
11.03.08(c): Histology of the Cardiovascular SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
11.03.08(c): Histology of the Cardiovascular SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
i. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of 6 to 8 glucose residues from this chain to another
site on the growing molecule. The enzyme amylo-
[1, 4]→[1, 6]-transglucosidase (branching enzyme)
forms this alpha-1, 6 linkage. (Fig. 10.4).
iii. To this newly created branch, further glucose units can
be added in alpha-1, 4 linkage by glycogen synthase.i. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of 6 to 8 glucose residues from this chain to another
site on the growing molecule. The enzyme amylo-
[1, 4]→[1, 6]-transglucosidase (branching enzyme)
forms this alpha-1, 6 linkage. (Fig. 10.4).
iii. To this newly created branch, further glucose units can
be added in alpha-1, 4 linkage by glycogen synthase.i. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of 6 to 8 glucose residues from this chain to another
site on the growing molecule. The enzyme amylo-
[1, 4]→[1, 6]-transglucosidase (branching enzyme)
forms this alpha-1, 6 linkage. (Fig. 10.4).
iii. To this newly created branch, further glucose units can
be added in alpha-1, 4 linkage by glycogen synthase.i. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of 6 to 8 glucose residues from this chain to another
site on the growing molecule. The enzyme amylo-
[1, 4]→[1, 6]-transglucosidase (branching enzyme)
forms this alpha-1, 6 linkage. (Fig. 10.4).
iii. To this newly created branch, further glucose units can
be added in alpha-1, 4 linkage by glycogen synthase.i. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of 6 to 8 glucose residues from this chain to another
site on the growing molecule. The enzyme amylo-
[1, 4]→[1, 6]-transglucosidase (branching enzyme)
forms this alpha-1, 6 linkage. (Fig. 10.4).
iii. To this newly created branch, further glucose units can
be added in alpha-1, 4 linkage by glycogen synthase.Vi. The glycogen synthase can add glucose units only in
alpha-1, 4 linkage. A branching enzyme is needed to
create the alpha-1, 6 linkages.
ii. When the chain is lengthened to 11–12 glucose
residues, the branching enzyme will transfer a block
of
Epithelium cellstissues histology
1. Chapter 4 Tissues and Histology • Tissues - collections of similar cells and the substances surrounding them • Tissue classification based on structure of cells, composition of noncellular extracellular matrix, and cell function • Major types of adult tissues – Epithelial – Connective – Muscle – Nervous • Histology: Microscopic Study of Tissues – Biopsy: removal of tissues for diagnostic purposes – Autopsy: examination of organs of a dead body to determine cause of death
Cartilage is a connective tissue structure that is composed of a collagen and proteoglycan-rich matrix and a single cell type: the chondrocyte. Cartilage is unique among connective tissues in that it lacks blood vessels and nerves and receives its nutrition solely by diffusion
Applied Anatomy of Orbit and Eyeball.pptxMathew Joseph
The eye sits in a protective bony socket called the orbit. Six extraocular muscles in the orbit are attached to the eye. These muscles move the eye up and down, side to side, and rotate the eye.
The extraocular muscles are attached to the white part of the eye called the sclera. This is a strong layer of tissue that covers nearly the entire surface of the eyeball.
Anatomy and Histology of Skin(Dermis & Epidermis).pptxMathew Joseph
Deep to the epidermis lies the dermis. It is a thick layer of connective tissue consisting of collagen and elastin which allows for skin's strength and flexibility, respectively. The dermis also contains nerve endings, blood vessels, and adnexal structures such as hair shafts, sweat glands, and sebaceous glands.
Anatomy of Female Reproductive System.pptxMathew Joseph
The female reproductive organs include several key structures, such as the ovaries, uterus, vagina, and vulva. The functions of these organs are involved in fertility, conception, pregnancy, and childbirth.
Histology/Micro Anatomy of Small Intestine.pptxMathew Joseph
The small intestine is an organ located in the gastrointestinal tract, between the stomach and the large intestine. It is, on average, 23ft long and is comprised of three structural parts; the duodenum, jejunum and ileum.
Functionally, the small intestine is chiefly involved in the digestion and absorption of nutrients. It receives pancreatic secretions and bile through the hepatopancreatic duct which aid with its functions.
Gross Anatomy & Histology of Muscle Tissue.pptxMathew Joseph
Muscle is a soft tissue, one of the four basic types of animal tissue. Muscle tissue gives skeletal muscles the ability to contract. Muscle is formed during embryonic development, in a process known as myogenesis. Muscle tissue contains special contractile proteins called actin and myosin which interact to cause movement. Among many other muscle proteins present are two regulatory proteins, troponin and tropomyosin.
Muscle tissue varies with function and location in the body. In vertebrates the three types are: skeletal or striated; smooth muscle (non-striated) muscle; and cardiac muscle.[1] Skeletal muscle tissue consists of elongated, multinucleate muscle cells called muscle fibers, and is responsible for movements of the body. Other tissues in skeletal muscle include tendons and perimysium.[citation needed] Smooth and cardiac muscle contract involuntarily, without conscious intervention. These muscle types may be activated both through the interaction of the central nervous system as well as by receiving innervation from peripheral plexus or endocrine (hormonal) activation. Striated or skeletal muscle only contracts voluntarily, upon the influence of the central nervous system. Reflexes are a form of non-conscious activation of skeletal muscles, but nonetheless arise through activation of the central nervous system, albeit not engaging cortical structures until after the contraction has occurred.
Arterial Supply and Venous Drainage of Pelvis.pptxMathew Joseph
The rich vascular supply of the pelvis not only supports the structures contained within it, including the bladder, rectum, and reproductive organs, but also extends to the lower extremities. For a complete understanding of vascular anatomy as it pertains into the endovascular procedures of interventional radiology, it is useful to discuss the vascular structures in sections, from the bifurcation of the aorta and the inferior vena cava to the level of the common femoral arteries and veins. We will also review the anatomy of the iliac vessels, including their branches, common variants, and various collateral pathways
The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the pancreatic duct to aid in digestion. The small intestine is about 5.5 metres (18 feet) long and folds many times to fit in the abdomen. Although it is longer than the large intestine, it is called the small intestine because it is narrower in diameter.
The small intestine has three distinct regions – the duodenum, jejunum, and ileum. The duodenum, the shortest, is where preparation for absorption through small finger-like protrusions called villi begins.[2] The jejunum is specialized for the absorption through its lining by enterocytes: small nutrient particles which have been previously digested by enzymes in the duodenum. The main function of the ileum is to absorb vitamin B12, bile salts, and whatever products of digestion that were not absorbed by the jejunum.
The sciatic nerves branches from your lower back through your hips and buttocks and down each leg. Sciatica refers to pain that travels along the path of the sciatic nerve
Nerve roots: L4-S3.
Motor functions:
Innervates the muscles of the posterior thigh (biceps femoris, semimembranosus and semitendinosus) and the hamstring portion of the adductor magnus (remaining portion of which is supplied by the obturator nerve).
Indirectly innervates (via its terminal branches) all the muscles of the leg and foot.
Sensory functions: No direct sensory functions. Indirectly innervates (via its terminal branches) the skin of the lateral leg, heel, and both the dorsal and plantar surfaces of the foot.
On the front of the thorax the most important vertical lines are the midsternal, the middle line of the sternum; and the mammary, or, better midclavicular, which runs vertically downward from a point midway between the center of the jugular notch and the tip of the acromion
The urethra is a passageway located in your body's pelvic region. The walls of the tube are thin and made up of epithelial tissue, smooth muscle cells and connective tissue. The urethra has two different types of sphincters, or muscles that act as valves that open or close
Karyotyping is the process by which photographs of chromosomes are taken in order to determine the chromosome complement of an individual, including the number of chromosomes and any abnormalities.
The term is also used for the complete set of chromosomes in a species or in an individual organism and for a test that detects this complement or measures the number.
The main artery of the lower limb is the femoral artery. It is a continuation of the external iliac artery (terminal branch of the abdominal aorta). The external iliac becomes the femoral artery when it crosses under the inguinal ligament and enters the femoral triangle.
In the femoral triangle, the profunda femoris artery arises from the posterolateral aspect of the femoral artery. It travels posteriorly and distally, giving off three main branches:
Perforating branches – Consists of three or four arteries that perforate the adductor magnus, contributing to the supply of the muscles in the medial and posterior thigh.
Lateral femoral circumflex artery – Wraps round the anterior, lateral side of the femur, supplying some of the muscles on the lateral aspect of the thigh.
Medial femoral circumflex artery – Wraps round the posterior side of the femur, supplying its neck and head. In a fracture of the femoral neck this artery can easily be damaged, and avascular necrosis of the femur head can occur.
The lungs are a pair of spongy, air-filled organs located on either side of the chest (thorax). The trachea (windpipe) conducts inhaled air into the lungs through its tubular branches, called bronchi. The bronchi then divide into smaller and smaller branches (bronchioles), finally becoming microscopic.
The bronchioles eventually end in clusters of microscopic air sacs called alveoli. In the alveoli, oxygen from the air is absorbed into the blood. Carbon dioxide, a waste product of metabolism, travels from the blood to the alveoli, where it can be exhaled. Between the alveoli is a thin layer of cells called the interstitium, which contains blood vessels and cells that help support the alveoli.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
How to Give Better Lectures: Some Tips for Doctors
Histology of Connective Tissue.pptx
1. HISTOLOGY OF
CONNECTIVE TISSUE
Dr Mathew Joseph
MBBS,MD(AIIMS),BCC(Palliative Medicine)
Assistant Professor
Department of Anatomy
Amala Institute of Medical Sciences, Thrissur
2. CONNECTIVE TISSUE
One of the 4 basic tissues which gives structural and
metabolic support to the organ and other tissues of
the body.
It connects other tissues.
3. Functions
• Support Structural & Mechanical
• Packing Fills spaces, Shape to the
organ
• Storage Adipose tissue: energy
Loose areolar CT: water & Electrolytes
• Transport Medium for Nutrients &
Metabolic wastes
• Repair Fibroblasts:matrix and fibres
• Defense Cells: Phagocytosis or
Antibodies
8. Function
• Fixed Cells:
Production & Maintanance of Extracellular matrix.
• Free Cells:
Tissue reaction to injury or invasion of micro organisms.
9. Fibroblast
• Most numerous cell type (PCTC).
• Mesenchymal origin
• Fusiform with slender cytoplasmic process
• Cental large oval nucleus
• Old and inactive - Fibrocytes
• Contractile cells - Myofibroblast
• Wound repair
• Responsible for fiber production
• Reticular tissue
11. Adipocytes
• Lipocytes - Lipid storing
• Spherical - Peripheral rim of
cytoplasm - Eccenteric nucleus -
Central large lipid droplet.
• Appears as empty space **
• Incapable of division
• Aggregate in adipose tissue with
reticular fibre.
• Sudan III, Sudan Black
25. Collagen Fibre
• White colour when fresh
• Do not branch - wavy - Bundles
• Collagen protein forms Fibres
• Fibres composed of fibril made of
microfibrils
• Micro fibrils made up
tropocollagen-striations
• Synthesized by fibroblast
26. Collagen
• Tropocollagen is
synthesized by
fibroblasts and released
into extracellular space
where they get
polymerized to form
collagen fibrils
• Collagen on boiling gives
gelatin
• More than 25 types are
present
Collagen is also synthesized
by Chondroblasts -
Cartilages
Osteoblasts : in bone
Smooth Muscle: in blood
vessels
Odontoblasts: in the tooth
29. Elastic fibre
• Yellow in color when fresh
• Composed of elastin protein
• Singly present
• Branched and anastomose forming a
network
• Can be stretched (one and a half times)
• Synthesized by fibroblast and smooth
muscle cells in blood vessels
• Found in ligamentum flava, ligamentum
nuchae, large arteries
• Elastase
30. Reticular fibre
• Structurally similar to collagen fibres
• Are very thin Immature collagen fibre
• Actively branch to form delicate
network therefore named Reticular
• Form supportive framework of
lymphoid tissue - S, LN - LIV KID
• Stained black by silver salts
(argyrophillic)
• Composed of Collagen Type III
31. Ground Substance
• Transparent & Homogeneous - Fills spaces between
cells and fibres.
• Fibroblasts - Chondrocytes - Osteocytes - Smooth
muscles
• Acts as a moleculer sieve facilitating diffusion
between blood and tissues.
Composition
• Mucopolysaccharides - Proteoglycans -
Glycosaminoglycans
• Structural Glycoproteins
• Water & Electrolytes
32. • Mucopolysaccharides(Glycosaminoglycans):
Consistency & viscocity of GS, serves as a physical
barrier in spreading infection. Examples: Hyaluronic
Acid & Heparan Sulphate.
• Structural Glycoproteins: Adhesion of cells to the
neighbouring cells. Examples: Fibronectin(Dermis),
Chondronectin(in Cartilage) & Laminin(in basement
membrane)
• Water & Electrolytes: Maintenance of Fluid balance.
33. Ground substance
• Polysacchrides - hexurate or galectose
• Carbohydrate protein complex (proteoglycanes)-
1- mucopolysacchride (glucosaminoglycanes)
NonSulphates-chondroitin and hyluronic
acid
Sulphates - chondotinesulphate, heparitine
sulphate, keratohyline
2- glycoprotienes- fibronectine(dermis),
chondronectine (cartilage), laminin (b.m)
• water & minerals
35. Classification of Connective Tissues
• Loose areolar connective tissue - subperitoneal
tissue, endomysium, lamina propria
• Dense collagenous C T
Regular- tendon, ligament, aponeurosis
Irregular-dermis of skin
• Connective T with special properties
Elastic-Ligamentum nuchae
Mucoid/ Embryonic tissue- Wharton’s jelly
Reticular Tissue- Stroma of lymphoid organ
55. Self Assessment
• Plasma Cells are derived from:
1. Monocytes
2. Basophils
3. T lymphocytes
4. B Lymphocytes
56. • Large number of elastic fibres are present in
1. Tendon
2. Ligamentum Nuchae
3. Basement Membrane
4. Aponeurosis
57. • The fat cells of Multilocular adipose tissue (Brown fat)
is characterized by the presence of
1.Spherical central nucleus and many lipid droplets.
2.Flat peripheral nucleus and single lipid drop
3. Flat central nucleus and single lipid droplet
4. Thin rim of cytoplasm