The glyoxylate cycle is an anabolic metabolic pathway that allows certain organisms, such as plants and fungi, to convert fats into carbohydrates by utilizing acetyl-CoA derived from the β-oxidation of fatty acids. This cycle occurs in glyoxysomes and involves enzymes that are isoenzymes of the TCA cycle, facilitating the production of succinate and ultimately glucose. It is regarded as a variant of the citric acid cycle, crucial for carbon assimilation and energy storage in these organisms.

1. GlyoxYLate
cycle
Shylesh Murthy I A
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2. The Glyoxylate Cycle
Another Process Involving Glycolytic
Enzymes and Metabolites

3. A series of metabolic reactions by which many
different organism utilise fats for the synthesis of
carbohydrate

4.  Anabolic metabolic pathway occurring in plants, and several
microorganisms , fungi not animals.
 Occurs in glyoxysome
 The enzymes common to the TCA cycle and the
glyoxysomes are isoenzymes, one specific to mitochondria
and the other to glyoxysomes.
 The glyoxylate cycle allows plants to use acetyl-CoA
derived from β-oxidation of fatty acids for carbohydrate
synthesis (use fats for the synthesis of carbohydrates).

7.  The glyoxalate cycle is regarded as an anabolic varient of
citric acid cycle .
 Acetyl coa produced from fatty acid oxidation condenses
with oxaloacetate to give citrate , which is then convert to iso
citrate .
 At this stage isocitrate lyase to succinate and glyoxalate.
 Another molecule of acetyl CoA Is now utilized to
combine with glyoolate to form malate synthase and the
malate so formed enters citric cycle

8. The glyoxylate cycle is a cyclic pathway that result
in conversion of 2 carbon fragment of Acetyl CoA TO 4
carbon compound succinate then succinate is covert to
oxaloacetate and then glucose involving the reaction of
gluconeogenesis

9. References ; Biochemistry book by
U sathyanarayana
U. Chakrapani
page no.- 244
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_(Ahern_and_Rajagopal)/06%3A_Metabolism_I/6.06%3A_Glyoxylate_Pathway

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