This is a lecture by Ruth S. Hwu, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Hello readers.................!!!!!!!!!!!!!!
This is my 32nd powerpoint.....its regarding a form of childhood epilepsy, known as "LENNOX-GASTAUT SYNDROME".
It has been dealt with in the Therapeutics way, and in precise format.
Do look into it and give your reviews!!!!
Thank you!!!!
@rxvichu-alwz4uh!!!!
:) :)
Hello readers.................!!!!!!!!!!!!!!
This is my 32nd powerpoint.....its regarding a form of childhood epilepsy, known as "LENNOX-GASTAUT SYNDROME".
It has been dealt with in the Therapeutics way, and in precise format.
Do look into it and give your reviews!!!!
Thank you!!!!
@rxvichu-alwz4uh!!!!
:) :)
Pathology of Central nervous system /certified fixed orthodontic courses by I...Indian dental academy
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Summary and illustrations of various traumatic brain injury including primary and secondary lesions as well as limited information on indications of brain imaging in trauma
GEMC: ENT Case Files: Resident Training Open.Michigan
This is a lecture by Dr. Matt Dawson and Dr. Zach Sturges from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Procedural Sedation in the Emergency Department: Resident TrainingOpen.Michigan
This is a lecture by Dr. Zach Sturges from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Status Epilepticus (SE): Resident TrainingOpen.Michigan
This is a lecture by Dr. C. James Holliman from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
2014 gemc-nursing-lapham-general survey and patient care managementOpen.Michigan
This is a lecture by Dr. Jeremy Lapham from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Approach to internship (mbbs in bangladesh perspective)Pritom Das
Some slides are taken from different textbooks of medicine like Davidson, Kumar and Clark and Oxford, and some from other presentations made by respected tutors. These resources are free for use, and I do not claim any copyright. Hoping knowledge remains free for all, forever.
This is a lecture by Dr. Andrew Wong from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC - Measles, Mumps, Rubella - for NursesOpen.Michigan
This is a lecture by Katherine A Perry from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: “Taming the Wild Child” - Pearls, Pitfalls and Controversies in Pediatr...Open.Michigan
This is a lecture by Dr. Jeff Holmes from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Joseph House from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Joseph House from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Jim Holliman, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Alterations in Body Temperature: The Adult Patient with a Fever- Reside...Open.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Rapid Sequence Intubation & Emergency Airway Support in the Pediatric E...Open.Michigan
This is a lecture by Michele Nypaver, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Disorders of the Pleura, Mediastinum, and Chest Wall- Resident TrainingOpen.Michigan
This is a lecture by Andrew Barnosky, DO from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Dental Emergencies and Common Dental Blocks- Resident TrainingOpen.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Arthritis and Arthrocentesis- Resident TrainingOpen.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Bursitis, Tendonitis, Fibromyalgia, and RSD- Resident TrainingOpen.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Right Upper Quadrant Ultrasound- Resident TrainingOpen.Michigan
This is a lecture by Jeff Holmes from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Nursing Process and Linkage between Theory and PracticeOpen.Michigan
This is a lecture by Jeremy Lapham from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Jessica Holly from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: The Role of Radiography in the Initial Evaluation of C-Spine TraumaOpen.Michigan
This is a lecture by Dr. Stephen Hartsell from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Jim Holliman from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Sickle Cell Disease: Special Considerations in Pediatrics- Resident Tra...Open.Michigan
This is a lecture by Hannah Smith, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
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Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
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Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
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Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
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A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Azure Interview Questions and Answers PDF By ScholarHat
GEMC- Pediatric Neurologic Emergencies- Resident Training
1. Project: Ghana Emergency Medicine Collaborative
Document Title: Pediatric Neurologic Emergencies
Author(s): Ruth S. Hwu, MD (Washington University in St. Louis)
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2
5. General Approach
Symptoms
• Headache
• Changes in mental status
• Weakness (focal or
generalized)
• Paresthesias
• Vomiting
• Visual changes
• Difficulty with speech
• Difficulty walking
History
• Trauma
• Ingestion
• Exposure history
• Fever/Infection
• Onset of symptoms acute or
subacute?
5
6. Pediatric Neurologic Exam
• Depending on age, may not be able to go head-
to-toe like adults
• Starts with initial observation, how they play and
interact
– Look at the face to see if there is any facial droop
– Look for dysmorphic features or skin findings
• Use toys/shiny objects, test how they track for
extraocular movements
– Bring objects into their peripheral vision for visual
fields
6
7. Pediatric Neurologic Exam
• Motor – watch for movement and use of all
extremities
– Any muscle atrophy
• Sensory – can test like adult after 5-6 years of age
• Tone
– Abduction of hips at rest could suggest hypotonia
(decreased muscle tone)
– Persistent arching of back and neck could indicate
hypertonia
7
9. Glasgow Coma Scale
Adult/Child Infant Score
Eye Opening Same Same
Best Verbal Oriented, appropriate Coos and babbles 5
Response Confused Irritable cries 4
Inappropriate words Cries to pain 3
Incomprehensible sounds Moans to pain 2
No response No response 1
Best Motor Obeys commands Moves spontaneously 6
Response Localizes to pain Withdraws to touch 5
Withdraws to pain Withdraws to pain 4
Flexion to pain Flexion to pain 3
Extension to pain Extension to pain 2
No response No response 1
10
10. Seizures: The Terminology
• Cryptogenic (or idiopathic) = no known
precipitating factor
• Provoked seizure = a precipitant can be
identified
• Status epilepticus = prolonged seizure longer
than 30 minutes (5 minutes) or recurrent
seizures and patient does not regain
consciousness in between
11
12. Case 1
A mother runs into the emergency department holding
her 3 year-old son in her arms. He has mostly jerking of
his right side with his eyes also going to the left. He is
foaming at the mouth. It has been going on for 15
minutes, and his lips are slightly blue. What do you do
first?
A. Give diazepam 0.5 mg/kg rectally
B. STAT head CT
C. Suction his mouth and put him on oxygen
D. Start an IV
13
13. Case 1
A mother runs into the emergency department holding
her 3 year-old son in her arms. He has mostly jerking of
his right side with his eyes also going to the left. He is
foaming at the mouth. It has been going on for 15
minutes, and his lips are slightly blue. What do you do
first?
A. Give diazepam 0.5 mg/kg rectally
B. STAT head CT
C. Suction his mouth and put him on oxygen
D. Start an IV
14
14. Seizure Management
• ABC!!!
– Airway: clear secretions, place nasal or
oropharyngeal airway if obstructing
– Breathing: place patient on oxygen
– Circulation: obtain IV or IO access
• Laboratory studies
– Fingerstick blood sugar
– Electrolytes (Na, K, Ca, Mg, P)
– Full blood count (FBC)
– Other tests: liver function panel, ammonia, toxicology
screens, antiepileptic drug levels, lumbar puncture
15
15. Acute Treatment of Seizure
Seizure > 5 minutes:
Lorazepam 0.1mg/kg (max 4mg) IV or diazepam 0.2-0.4 mg/kg (max 10mg) IV
Phenytoin (Epinutin) 20 mg/kg IV (max 1500mg), give over 10 min
Phenytoin (Epinutin) 10 mg/kg IV (max 1500mg), give over 5-10 min
Phenobarbital 20 mg/kg IV (max 2000mg), give over 20 min
Phenobarbital 10 mg/kg IV (max 2000mg), give over 10 min
May repeat once
No response after 5 min
No response after 5 min
No response after 5 min
16
16. Acute Treatment of Seizure
• If refractory:
– Continuous infusion of midazolam
• Evaluate the airway continuously
– If need to intubate, prefer shorter-acting paralytic
such as succinylcholine if no contraindications
– Use end tidal carbon dioxide monitoring and
pulse-ox if available
17
18. No IV Access
• Diazepam 0.5 mg/kg (max 20mg) per rectum
• Midazolam 0.2 mg/kg (max 7mg)
intramuscularly
• Midazolam 0.2 mg/kg (max 10mg)
intranasally
19
19. Unresponsive Seizures
• Hypoglycemia = 40 mg/dL or 2.2 mmol/L
– 25% dextrose water (D25W) 2-4 ml/kg or for
infants 10% dextrose water (D10W) 5-10ml/kg
– Give dextrose until asymptomatic
• Hyponatremia = serum sodium (Na) < 135
mEq/L
– Severe hyponatremia = Na < 120 mEq/L
– 3% sodium chloride (NaCl) 2-5 ml/kg
– Correct sodium acutely until seizures stop
20
20. Further Testing
• Emergent noncontrast head CT if:
– Prolonged seizure
– Focal neurological exam
– Concern for trauma or hemorrhage
– Prolonged decreased level of consciousness
– Otherwise could wait for brain MRI if needed
• Lumbar puncture for concerns of meningitis or
encephalitis
• Look for any signs of ingestion
21
21. Febrile Seizures
• 2-5% of children, most common convulsive
disorder in young children
• Seizure occurring at 6 months to 5 years of
age associated with fever
• Simple febrile seizure (85%) = generalized,
once over 24 hours, less than 15 minutes
• Complex febrile seizure (15%) = focal, recur
within 24 hours, greater than 15 minutes
22
22. Febrile Seizures
• 33% of children have one recurrence, 9% have ≥ 3
episodes
– Increased risk of recurrence if younger and had lower fever
with first seizure
• < 5% develop epilepsy
• No laboratory studies required except to find source of
infection
– Lumbar puncture if less than 6 months
– Consider lumbar puncture if 6-12 months, pretreated with
antibiotics, complex febrile seizure, altered mental status,
signs of meningitis or encephalitis
• Generally do not need head CT
23
24. Stroke: Pathophysiology
• Ischemic or embolic stroke
• Hemorrhagic stroke
– 30-60% of strokes in children vs. 20% in adults are
hemorrhagic
25
25. Ischemic Stroke
• 50% of children with ischemic stroke have
underlying risk factor, most commonly congenital
heart disease
• 94% present with hemiplegia
• Other clinical manifestations:
– Hemianopsia
– Dysphagia
– Vertigo, ataxia
– Headache in older children
– Seizures as presenting symptom in younger children
26
26. Hemorrhagic Stroke
• Pathophysiology
– Intraparenchymal hemorrhage
– Nontraumatic subarachnoid hemorrhage, most
often from intracranial aneurysm
• Most commonly presents with headache,
altered level of consciousness, and vomiting
27
27. Stroke Management
• Noncontrast head CT to rule out hemorrhage
• Manage blood pressure (beware of hypotension)
• Ischemic stroke
– Anticoagulate with LMWH (enoxaparin) or heparin
– Thrombolytics untested in children
– Exchange transfusion if have sickle cell disease
– Cardiac echo
• Hemorrhagic stroke
– Correct any coagulation defects
– Consult neurosurgery if rapidly expanding hematoma
needs evacuation
28
29. Increased Intracranial Pressure
• Cerebral perfusion pressure (CPP) = mean arterial
pressure (MAP) – intracranial pressure (ICP)
– Increase in ICP leads to decrease in CPP
• The noncompliant cranium can only
accommodate a certain volume of intracranial
contents and then have exponential increase in
pressure
– Can have delayed reaction in infants with open
sutures and fontanelles
30
30. Effect of Increased Volume on
Intracranial Pressure
Additional Volume
IntracranialPressure
31
31. Causes of Increased Intracranial
Pressure
• Tumors
• Increased cerebral spinal fluid production or
decreased reabsorption
• Intracranial hemorrhage
• Cerebral edema
• Increased ICP will decrease blood flow to
brain, leads to cerebral ischemia and
secondary injury
32
33. Tentorial Herniation (1,2)
• Herniation of
parahippocampal gyrus and
uncus of temporal lobe
through tentorial notch
• Temporal cortex presses
against brainstem and
cranial nerve III
• Headache, decreased
mental status, blown pupil,
ptosis, loss of medial gaze,
decerebrate posturing
• Cushing’s triad as brainstem
compressed -> respiratory
arrest
Brain_herniation_types.svg (Wikimedia Commons)
34
34. Tonsillar/Cerebellar Herniation (6)
• Cerebellar tonsils
herniate through foramen
magnum
• Usually from posterior
fossa mass lesion
• Compresses aqueduct of
Sylvius and causes
hydrocephalus
• Neck pain, vomiting,
decreased mental status,
bradycardia, hypertension
35
Brain_herniation_types.svg (Wikimedia Commons)
35. General Management of ICP
• ABCs
– May need to intubate if GCS ≤ 8, no gag, poor
ventilation
– Give supplemental oxygen
– If normotensive, avoid excess fluid administration
• Once intubated, sedation if agitated to prevent
spikes in ICP
– Propofol would not be ideal due to risk of hypotension
• Head CT if signs of increased intracranial pressure
36
36. Management of ICP
• Elevate head of bed to 30 degrees to promote
venous drainage of head
• Hyperventilation with PCO2 of 30-25
– Hypocarbia leads to reflex vasoconstriction
– Caution: if overhyperventilate, can cause excess
vasoconstriction and decreased blood flow
37
37. Case 2
A 6 year-old boy is brought in after a car accident.
He was unrestrained and flew into the front
windshield. On arrival, vital signs are HR 68, BP
80/50. He has decorticate posturing and blown
right pupil. You intubate him and elevate the head
of the bed to 30 degrees. What is the best thing to
do next?
A.Give mannitol 1gm/kg
B.Give 3% NS 3ml/kg
C.Hyperventilate
D.Take the child for emergent head CT
38
38. Case 2
A 6 year-old boy is brought in after a car accident.
He was unrestrained and flew into the front
windshield. On arrival, vital signs are HR 68, BP
80/50. He has decorticate posturing and blown
right pupil. You intubate him and elevate the head
of the bed to 30 degrees. What is the best thing to
do next?
A.Give mannitol 1gm/kg
B.Give 3% NS 3ml/kg
C.Hyperventilate
D.Take the child for emergent head CT
39
39. Mannitol vs. Hypertonic Saline
IV Mannitol (0.5 to 1gm/kg)
• Increases serum osmolarity
and draws free water into
vasculature
• Blood less viscous so
improves cerebral blood
flow
• Onset in a few minutes
• Osmotic diuretic so will also
lead to volume depletion
3% saline (2-5 ml/kg)
• Can also be given as a
continuous drip
• Hyperosmolarity leads to
decreased blood velocity
and improved cerebral
blood flow
• Does not have diuretic
effect
• Preferred if not
hemodynamically stable
40
41. Brain Tumors
• Account for 20% of all cancers in children,
second to leukemia
• Most commonly gliomas/astrocytomas in
children
• Majority are located in the posterior fossa
• Ominous signs associated with headaches
– Persistent vomiting
– Vomiting on awakening
42
42. Brain Tumor Management
• Noncontrast CT if patient unstable
– Can evaluate for hemorrhage, tumor-related
obstructive hydrocephalus, mass effect
• If patient is stable, brain MRI is study of choice
– More sensitive for identifying small brain tumors
– Better visualization of the posterior fossa
• Neurosurgery consult
43
43. Hydrocephalus
• Due to either increased cerebral fluid production or
decreased absorption
– Noncommunicating hydrocephalus – CSF in the ventricular
system is blocked by a congenital or an acquired defect
– Communicating hydrocephalus – block in absorption at the
meningeal surfaces
• Present with increasing head circumference, vomiting,
sleepiness, irritability, downward deviation of the eyes
("sunsetting"), ataxia
• Noncontrast head CT -> dilated ventricles
– Can do head ultrasound if fontanelle is open
• Neurosurgery consult for CSF shunt
44
44. Shunt Malfunction
• Many different types of shunts
– All contain a ventricular catheter, one-way valve, and distal
tubing into peritoneal cavity, pleural cavity, or right atrium
– Some have reservoir available for percutaneous tapping
• Risk of shunt failure is highest first months after
placement
– 40% fail in first year, 80% by 10 years
• Evaluate for malfunction using head CT to evaluate
ventricles and shunt series to evaluate shunt tubing
• If emergent, can try to access the shunt, but for
definitive care, need neurosurgery consult for revision
45
45. Traumatic Brain Injury
• In United States, 475000 children younger
than 14 years old visit the ED annually for
head injury
• Traumatic brain injury can be divided into 2
components:
– Primary brain injury due to the traumatic event
itself
– Secondary brain injury from hypoxia,
hypoperfusion, metabolic derangements during
resuscitation
46
46. Parenchymal Injuries
• Cerebral contusion
– Common in children due to the movement of a relatively
mobile brain within a fixed skull
– Most common in frontal and temporal lobes
– Associated with risk of late intraparenchymal hematoma
– Admit for observation
• Diffuse axonal injury
– Diffuse primary injury to the white matter tracts of the
brain
– Due to severe acceleration and deceleration or angular
forces to the brain
– Usually from motor vehicle crashes or child abuse
47
50. Epidural Hematoma
• Due to blunt impact to the cranium, often with skull
fracture with laceration of epidural vessels
• In children, mostly from falls
• Classic presentation has initial loss of consciousness
then “lucid interval” of several hours, but children
often don’t have this presentation
• Management: craniotomy with drainage of hematoma
and repair of lacerated epidural vessels
– Sometimes observation if < 30 mL in volume or thickness <
2 cm with normal physical exam
51
53. Subdural Hematoma
• Usually from mechanisms that are associated with
shear forces that tear bridging veins
– In older children, likely MVC
– Strong association with child abuse in younger children
• Have initial loss of consciousness and decreased
mental status
– Patients who present in coma or pupillary abnormalities
have poorer prognosis
• Management:
– Non-operative if not severely ill
– Drainage if signs of increased ICP
54
56. Subarachnoid Hematoma
• Tearing of small vessels in pia mater
• Subarachnoid space is large, so blood in SAH can
distribute widely
• Presents with headache and signs of meningeal
irritation (nausea, vomiting, neck stiffness)
• Can usually be detected on noncontrast head CT
but sensitivity only 90%
• Management: admit for observation, generally
non-surgical
– May need prophylactic anticonvulsant (Epinutin,
Levetiracetam)
57
57. Who gets a head CT?
• Can be difficult to decide in children with
minor head trauma (GCS of 14-15)
• Lethal malignancy from pediatric head CT is
between 1 in 1000 and 1 in 5000, with higher
risk at a younger age
• Prospective multi-center study involving
42412 patients used to develop a prediction
tool (Kuppermann et al, 2009)
58
58. Head CT algorithm for children < 2yo
and GCS 14-15
Kupperman N, et al. Lancet 2009.
59
59. Head CT algorithm for children ≥ 2yo
and GCS 14-15
Kupperman N, et al. Lancet 2009.
60
61. Guillain-Barré
• Acute inflammatory demyelinating
polyradiculoneuropathy
• The most common cause of motor paralysis in
children
– Uncommon prior to 3 year old
• Antecedant viral infection triggers inflammation
and demyelination from autoimmune process
– Adenovirus, Ebstein-Barr virus, cytomegalovirus,
human immunodeficiency virus, varicella-zoster virus,
vaccines, Mycoplasma pneumoniae and
Campylobacter jejuni
62
62. Guillain-Barré Signs and Symptoms
• Weakness
• Leg and back pain
• Abnormal gait in younger children
• Sensory loss
• Decreased deep tendon reflexes
• Bowel or urinary incontinence
• Autonomic dysfunction (hypotension)
• Cranial nerve involvement in 30-40% of cases
• Respiratory paralysis occurs in 20-30%
• Can progress for days to weeks
63
63. Guillain-Barré
• Diagnosis:
– Cerebrospinal fluid has elevated protein without
elevated white count (pleocytosis)
• Management:
– Hospitalized and observed due to potential respiratory
compromise
– Generally self-limited, 90% have complete or near-
complete recovery
– Consider plasmapheresis and IVIG in the more
severely effected children
64
64. Myasthenia Gravis
• Due to autoantibody against acetylcholine
receptor proteins
• 3 types:
– Transient neonatal
– Infantile
– Juvenile (most common)
• Mean age of onset 8 years old
• 4:1 females
65
65. Myasthenia Gravis
• Clinical manifestations:
– Mostly affects cranial nerves, ptosis
– Generalized truncal weakness in 50%, worsens by end
of day
• Diagnosis: Tensilon test (edrophonium)
• Management:
– Check for respiratory compromise, may need
ventilatory support
– Admit if severe respiratory compromise or weakness
– Treat with Mestinon (cholinesterase inhibitor)
66
66. Acute Cerebellar Ataxia
• Most common cause of ataxia in children
• Typically presents 1-4 years of age
• Parainfection or postinfection demyelinization:
– Most commonly after varicella
– EBV, enterovirus, HSV, influenza, Mycoplasma, Q
fever
67
67. Acute Cerebellar Ataxia
• Symptoms 5-10 days after illness onset
– Acute truncal unsteadiness, possibly some
tremors and dysmetria
– Dysarthria
– Nystagmus
• Management:
– Head CT or brain MRI to rule out cerebellar mass
– Supportive treatment, resolves within 2 weeks
68
68. Infantile Botulism
• Due to intestinal colonization of Clostridium
botulinum
• Toxin impedes acetylcholine release from
nerve terminals
• If ingest contaminated honey or poorly
canned foods
– Honey given in United States as dietary
supplement, for cough
– Rare in Africa
69
69. Botulism: Clinical Manifestations
• Acute weakness in well infants < 12 mo old
• Constipation, then lethargy and poor feeding
• Poor suck and gag
• Poorly reactive pupils
• Ptosis, facial weakness, oculomotor palsies
• Decreased deep tendon reflexes
70
70. Botulism: Management
• Diagnose by identifying C. botulinum spores in
the stool
– Have serum assay for toxin but often negative in
infants
• Manage airway, may not be ventilating
appropriately
– 60-80% require intubation and mechanical ventilation
• Human-derived botulinum immune globulin
(need Center for Disease Control approval)
71
71. Spinal Cord Trauma
• Spinal cord injury is rare in pediatrics,
approximately 2 of 100,000 children per year
• In children with cervical spine injury, less than
5% are in children less than 2 years old
• Most common cause is motor vehicle crash or
being hit by car
72
72. The Immature Spine
• Pediatric spine typically matures around 8 years
• Ligaments of the spine are more lax and facet
joints are more horizontal, allowing for
subluxation of vertebrae
• Paraspinous musculature less developed
• Fulcrum of C-spine is C2-C3 in young children
rather than C5-C7
– Fulcrum migrates to C5-6 by 14 years of age
– Upper cervical spine more prone to injury
73
73. Spinal Cord Injury
• Associated with significant mechanisms of
injury, often have evidence of other injuries
• If high cervical cord injury, often have spinal
shock (bradycardia and hypotension)
• Suspect whenever have complaints or exam
findings of decreased motor strength,
decreased or absent reflexes, rectal tone
74
74. Risk Factors Associated with C-spine
Injury in Children
• Case-control study of children < 16 years old after blunt
trauma, included 540 children
• 8 factors associated with C-spine injury (having 1 or more
98% sensitive, 26% specific)
– Altered mental status
– Focal neurologic findings
– Neck pain
– Torticollis
– Substantial torso injury
– Conditions predisposing to cervical spine injury (trisomy 21)
– Diving
– High risk MVC
75
75. Spinal Injury Management
• ABCs
• Immobilization is mainstay of therapy
– Use rigid cervical collar and also rigid long board for
transport, but take off board as soon as possible
• Consult neurosurgery
– May need emergent laminectomy if have compressive
lesion
• Use of steroids in pediatric spinal cord injury is
controversial
76
76. Spinal Imaging
• Obtain plain radiographs to evaluate for fractures or
subluxations
– 90% sensitive for bony cervical spine injury
– Good option for screening in alert patient
– Flexion-extension plain radiography helps evaluate for
ligamentous stability but not useful acutely
• CT 100% sensitive for bony cervical spine injury
– First choice for critically injured children
– To avoid unnecessary radiation, algorithms available for C-
spine injury
• MRI 100% sensitive for bony, ligamentous, and cord
injuries but takes more time
77
83. Atlantoaxial Dislocation
• “Cock robin” torticollis – chin rotation to the
contralateral side and flexion of neck
• Children predisposed due to ligamentous laxity
and robust synovium
• C-spine x-rays show only asymmetric positioning
of dens relative to lateral masses and have a
normal neurologic exam
• Management: rigid collar, pain medication and
muscle relaxant
– See spine specialist in 2 weeks
84
84. Dens Fractures
• In children, weakest point
in the axis (C2) is
cartilaginous subdental
epiphysis
– Present until 7 years old
– Can be hard to tell if there
is fracture at epiphysis
• From forceful neck flexion
• If significantly displaced,
can cause neurologic
deficit
James Heilman, MD (Wikimedia Commons)
85
85. Chance Fractures
• Hyperflexion injury over a seat belt during
sudden deceleration in a motor vehicle
accident
– Children at risk because the lap belt rides higher
• Leads to anterior vertebral compression with
rupture of ligaments
• Associated with intraabdominal injuries
– Tears and transections of duodenum, jejunum,
and mesentary
86
86. Spinal Shock
• Flaccid below level of lesion
• Absent reflexes
• Autonomic dysfunction leading to hypotension,
bradycardia, and hypothermia
– Hypotension characterized by low diastolic blood
pressure and wide pulse pressure from loss of vascular
tone
– Refractory to fluids
• Treat with primary alpha-agonists such as
norepinephrine and phenylephrine
87
87. Summary
• Neurologic emergencies in pediatrics can be
caused by many reasons
• Ensure ABCs are the first thing to be managed
• Let the history and exam help you determine
lab testing and imaging
88
88. Resources
Chameides L, Samson RA, Schexnayder SM, Hazinski MF, ed (2011). Pediatric Advanced Life Support Provider Manual.
American Heart Association: United States of America.
Chiang VW. Seizures. Textbook of Pediatric Emergency Medicine, 16th ed. Philadelphia, PA: Lippincott Williams &
Wilkins; 2010.
Gorelick MH, Blackwell CD. Neurologic Emergencies. Textbook of Pediatric Emergency Medicine, 16th ed. Philadelphia,
PA: Lippincott Williams & Wilkins; 2010.
Greenes DS. Neurotrauma. Textbook of Pediatric Emergency Medicine, 16th ed. Philadelphia, PA: Lippincott Williams &
Wilkins; 2010.
Tse DS, Steele D. Neurosurgical Emergencies, Nontraumatic. Textbook of Pediatric Emergency Medicine, 16th ed.
Philadelphia, PA: Lippincott Williams & Wilkins; 2010.
Kotagal S. Neurological examination of the newborn. UpToDate. www.uptodate.com. Accessed January 18, 2014.
Kotagal S. Detailed neurologic assessment of infants and children. UpToDate. www.uptodate.com. Accessed January
18, 2014.
Kupperman N, Holmes JF, Dayan PS, et al. Identification of children at very low risk of clinically-important brain injuries
after head trauma: a prospective cohort study. Lancet. 2009; 374:1160-1170.
Leonard JC. Cervical spine injury. Pediatr Clin N Am . 2013; 60:1123-1137.
Leonard JC, Kuppermann N, Olsen C, et al. Factors associated with cervical spine injury in children after blunt trauma.
Ann Emerg Med. 2011; 58:145-155.
Subcommittee on febrile seizures. Clinical Practice Guideline – Febrile seizures: Guideline for the neurodiagnostic
evaluation of a child with simple febrile seizure. Pediatrics. 2011; 127:389-394.
89
90. Ischemic Stroke
Clot leads to reduction in cerebral blood flow and
hypoxic damage
National Heart Lung and Blood Institute (Wikimedia Commons)
91
91. Spinal Cord Injury: Anatomy Review
• Cord has ventral (motor) compartment and
dorsal (sensory) compartment
• Upper motor neurons originate on one side of
cerebral cortex, then cross at level of medulla
before entering spinal cord
• Sensory neurons originate at one side and
immediately cross other side before being
entering cord
92
93. Anterior Cord Syndrome
• Complete motor
paralysis
• Loss of pain and
temperature sensation
• Position and vibration
sense preserved
• Associated with severe
flexion injuryFpjacquot (Wikimedia Commons)
94
94. Brown-Sequard Syndrome
• Injury to one of the two
lateral sides of the cord
• Ipsilateral (same side of
injury) loss of motor
function and position
and vibratory sensation
• Contralateral (opposite
side of injury) loss of
pain and temperature
sensation
95
Fpjacquot (Wikimedia Commons)
95. Central Cord Syndrome
• Hyperextension injury
may cause more severe
injury to central regions
of cord
• Diminished or absent
upper extremity
function
• Preserved lower
extremity function
96
Fpjacquot (Wikimedia Commons)
96. SCIWORA
• Spinal cord injury without radiographic
abnormalities
• Children at high risk because of the flexibility
of their spinal column
– Can sublux transiently and cause compression,
then return to normal position prior to x-ray
• Some have positive MRI,
97
97. Subfalcine Herniation (3)
• One cerebral
hemisphere herniates
beneath the falx cerebri
to the opposite side
• Usually from unilateral
supratentorial mass
lesion
• Bilateral leg weakness,
disturbances of bladder
control
98
Brain_herniation_types.svg (Wikimedia Commons)