This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Rheumatology Sheet from Rheumatology Department, Faculty of Medicine, Zagazig University, Egypt.
Disclaimer : not my slide. Just uploading for my personal use..
synovial fluid is the fluid which is present within the joint for lubrication, provide of nutrition, to prevent from shock. fluid analysis is very important in medical field for the diagnosis of many diseases, on the basis of which a patient may be properly treated.
Rheumatology Sheet from Rheumatology Department, Faculty of Medicine, Zagazig University, Egypt.
Disclaimer : not my slide. Just uploading for my personal use..
synovial fluid is the fluid which is present within the joint for lubrication, provide of nutrition, to prevent from shock. fluid analysis is very important in medical field for the diagnosis of many diseases, on the basis of which a patient may be properly treated.
This PPT is mainly for the III yr MBBS - Students for whom this topic is important. Moreover mainly day today clinical practice practising doctors will come across these types of cases.
A Power Point Presentation on the Disease Rheumatoid Arthritis covering everything from explanation and history to causes, effects, treatments, diagnosis, and prognosis.
GEMC- Bursitis, Tendonitis, Fibromyalgia, and RSD- Resident TrainingOpen.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Collagen Vascular Disease: Considerations for Emergent Management: Resi...Open.Michigan
This is a lecture by Dr. Joseph Hartmann from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC - Emergency Management of Ano-Rectal Disorders - Resident Training Open.Michigan
This is a lecture by Dr. Joseph Hartmann from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Emergency Management of Ano-Rectal Disorders: Resident TrainingOpen.Michigan
This is a lecture by Dr. Joseph Hartmann from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Lower Extremity Injuries- Resident Training Open.Michigan
This is a lecture by Dr, John Burkhardt from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
12.01.08(a): Rheumatoid Arthritis/Pathogenesis and Clinical Presentation of J...Open.Michigan
Slideshow is from the University of Michigan Medical School's M2 Musculoskeletal sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M2Muscu
GEMC- Injuries of the Lower Extremity: Knee, Ankle and Foot- Resident TrainingOpen.Michigan
This is a lecture by Dr. John Burkhardt from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
12.02.09(a): Other Inflammatory ArthritidesOpen.Michigan
Slideshow is from the University of Michigan Medical School's M2 Musculoskeletal sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M2Muscu
This is a lecture by Dr. Joseph Hartmann from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Acute Sinusitis - Resident Training Open.Michigan
This is a lecture by Dr. Jim Holliman from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Musculoskeletal Jeopardy: Resident Training Open.Michigan
This is a lecture by Dr. Jeff Holmes from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Disorders of the Pleura, Mediastinum, and Chest Wall- Resident TrainingOpen.Michigan
This is a lecture by Andrew Barnosky, DO from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC - Bone and Joint Infections - Resident TrainingOpen.Michigan
This is a lecture by Dr. Keith Kocher from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Keith Kocher from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Right Upper Quadrant Ultrasound- Resident TrainingOpen.Michigan
This is a lecture by Jeff Holmes from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC - Musculoskeletal Emergencies - for NursesOpen.Michigan
This is a lecture by Katherine A Perry from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
Similar to GEMC- Arthritis and Arthrocentesis- Resident Training (20)
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Jim Holliman, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Alterations in Body Temperature: The Adult Patient with a Fever- Reside...Open.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Rapid Sequence Intubation & Emergency Airway Support in the Pediatric E...Open.Michigan
This is a lecture by Michele Nypaver, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Dental Emergencies and Common Dental Blocks- Resident TrainingOpen.Michigan
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Joe Lex, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: Nursing Process and Linkage between Theory and PracticeOpen.Michigan
This is a lecture by Jeremy Lapham from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
2014 gemc-nursing-lapham-general survey and patient care managementOpen.Michigan
This is a lecture by Dr. Jeremy Lapham from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Jessica Holly from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC: The Role of Radiography in the Initial Evaluation of C-Spine TraumaOpen.Michigan
This is a lecture by Dr. Stephen Hartsell from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Dr. Jim Holliman from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Sickle Cell Disease: Special Considerations in Pediatrics- Resident Tra...Open.Michigan
This is a lecture by Hannah Smith, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
GEMC- Ghana Grab Bag Pediatric Quiz- Resident TrainingOpen.Michigan
This is a lecture by Hannah Smith, MD and Ruth S. Hwu, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Ruth S. Hwu, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
This is a lecture by Ryan LaFollette, MD from the Ghana Emergency Medicine Collaborative. To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.
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Model Attribute Check Company Auto PropertyCeline George
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
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We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Ethnobotany and Ethnopharmacology:
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The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
GEMC- Arthritis and Arthrocentesis- Resident Training
1. Project: Ghana Emergency Medicine Collaborative
Document Title: Arthritis and Arthrocentesis
Author(s): Joe Lex, MD (Temple University School of Medicine)
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2
4. What’s a joint like you doing in a nice girl like this??
Source Undetermined
4
5. Objectives 1. Differentiate among the three types of joints 2. Explain the pathology of joint inflammation 3. Develop a differential for arthritis, based on number of joints involved, location, and other characteristics
5
6. Objectives 4. Explain usefulness of various synovial fluid studies. 5. Demonstrate an appropriate technique for large joint arthrocentesis 6. Explain the pathophysiology and treatment for gout
6
7. Objectives 7. Differentiate “rheumatic fever” from “rheumatoid arthritis” from “rheumatism” 8. Be aware of quackery as it applies to treatment of arthritis
7
8. History of Arthritides •1680s: Sydenham describes gout, rheumatism, chorea •1808: term “rheumatic fever” •1876: urate crystals postulated to cause gout •1883: gonococcal arthritis •1907: osteoarthritis described
8
10. Three Joint Types •Synarthroses: suture lines of skull •Amphiarthroses: fibrocartilaginous unions of pubic symphysis and lower third of sacroiliac joint •Diarthroses = Synovial: most other joints
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13. Diarthrosis = Synovial Joints •Subchondral bone, convex against concave, covered by cartilage •Cartilage: collagen + proteoglycan •Lubricated, slide on each other •Surrounded by capsule supported by ligaments, tendons, and muscle •Lined with synovial membrane
13
25. Physical Exam 1.Warmth and effusion 2.Synovial thickening 3.Deformity 4.Tenderness: generalized or localized, articular or periarticular 5.Limited range of motion 6.Pain on movement
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26. Lab Studies •Limited diagnostic value •“Screening tests” –Bacterial: usually elevated WBC –Chronic rheumatic: mild anemia –ESR/CRP in most inflammatory •RF, ANA, ASO titers, Lyme serologies: for follow-up •Uric acid: not helpful in gout
26
36. Arthrocentesis •Critical diagnostic adjunct •Can be painless, safe, and simple when performed correctly •Diagnostic or therapeutic
Source Undetermined
36
37. Indications •Obtain joint fluid for analysis •Drain tense hemarthroses •Instill analgesics and anti- inflammatory agents •Prosthetic joints: only to rule out infection
37
39. Procedure •Cleanse skin with povidone-iodine, then air dry •Remove povidone-iodine with isopropyl alcohol –Intra-articular povidone-iodine can cause chemical irritation, inhibit bacterial growth leading to spuriously negative cultures in early septic joint
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40. Procedure •Place sterile drapes •Inject local anesthetic into skin –25- to 30-gauge needle –Intraarticular anesthetic can inhibit bacterial growth, cause spuriously negative culture in early septic joint
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41. Procedure •Aspirate large joints with large- bore needle (18 or 19 gauge) –Smaller joints: smaller-bore needle •Choose syringe size based on anticipated fluid volume •Remove as much fluid as possible –Optimizes diagnosis –Relieves pain from distention
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42. Arthrocentesis •Fat globules: diagnostic of fracture •Intraarticular morphine can provide relief for up to 24 hours –1 to 5 mg diluted in normal saline solution to a total volume of 30 ml
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44. Elbow – Lateral Approach
Flex elbow 90o Prep skin Insert needle in palpable bony notch between lateral epicondyle and olecranon
44
45. Knee – Lateral Approach
Extend knee, quadriceps and patella relaxed so patella can move mediolaterally. Needle into joint space just lateral to patella near its upper pole, parallel to the posterior (articular) surface.
45
51. Knee – Medial vs. Lateral •Follow “Sutton’s Law” •William “Slick Willie” Sutton (1901 – 1980): professional bank robber
51
52. Ankle
Palpate the medial and lateral malleoli with your thumb and index finger. The joint space is located one to one and a half cm above the line joining the tips of the malleoli.
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53. Ankle
Palpate the dorsalis pedis artery and choose a puncture site anywhere on the anterior aspect of the ankle, avoiding the dorsalis pedis artery.
53
58. Other Synovial Fluid Analysis •Glucose, lactic acid, viscosity, mucin clot, and total protein: limited utility, not recommended •Appropriate container –Cellular analysis: lavender (ethylenediaminetetraacetic acid) –Crystal analysis: green (heparin) –Chemical analysis, serology: red
58
59. Crystal Studies •Monosodium urate: needle shaped, birefringent negative –Parallel to compensator: yellow –Perpendicular: blue •Calcium pyrophosphate: polymorphic, birefringent positive –Parallel to compensator: blue –Perpendicular: yellow
59
60. Crystal Studies
Sodium urate crystals viewed under polarized light with a red plate makes those in the plane of the long axis of the red plate yellow, which indicates that they are negatively birefringent.
60
Source Undetermined
61. Crystal Studies
Calcium pyrophosphate crystal viewed under polarized light with a red plate. The crystal is aligned in the long axis of the red plate, so that it is bluish-white, which indicates that it is weakly positively birefringent.
61
Source Undetermined
62. Specific Arthritides There are more than 90
Preiser’s disease: avascular necrosis of scaphoid
62
Source Undetermined
64. Septic Arthritis •Synovium infected before degrading enzymes released •Children: hematogenous most common •Postoperative infection: ~10% of joint surgeries
64
65. Causes •Staphylococcus aureus: most common (even in sickle cell) •Others: streptococcus, Gram negatives, anaerobes •N. gonorrhoeae: 20% monarticular •<6 months: E. coli, group B strep •IV drug users: S. aureus, Gram negatives
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66. Clinical Features •Based on host’s concurrent medical conditions •Painful, hot, swollen •Typical: single joint –Knee: 40% to 50% –Hip: 13% to 20% –Shoulder: 10% to 15% •20% polyarticular
66
67. Clinical Features •History of fever: 80% •Shaking chills: 20% •Elevated sedimentation rate more common than leukocytosis •Blood cultures grow causative organism ~50% of the time •Radiographs not often useful
67
68. Management •Admit for joint drainage, IV antibiotics •Empiric therapy based on Gram’s stain •Parenteral narcotic analgesics, articular immobilization control pain and discomfort
68
70. Gouty Arthritis •Pod = foot; agra = trap, hunt •Podagra: foot goddess, a bad- tempered virgin, who attacked victims after they overindulged •Father was Dionysus (Bacchus), god of wine •Mother was Aphrodite (Venus), goddess of love
70
72. Gouty Arthritis •Galen (129-199 AD), an ex-gladiatorial surgeon in Rome, described gout as a discharge of the four humors of the body in unbalanced amounts into the joints (hence gout = gutta, a drop)
72
Pierre Roche Vigneron (Wikimedia Commons)
73. Be temperate in wine, in eating, girls and sloth Or the gout will seize you and plague you both
73
Benjamin Franklin:
74. Pathophysiology •Uric acid crystal deposits from supersaturated extracellular fluid •Risk factors: obesity, hypertension, diabetes, alcohol, proximal loop diuretics, lead poisoning •During attack: crystals ingested by PMNs inflammation
74
75. Pathophysiology •Middle-aged men, post- menopausal women •Increased uric acid usually present for 20 years before first attack •Uric acid often normal
75
76. Presentation •Great toe MTP joint in 75% –Also tarsal, ankle, knee, wrist –Up to 40% polyarticular •Pain excruciating at onset –Can mimic septic joint –Usually self-limited •Systemic symptoms usually minimal or absent
76
78. Presentation •Tophi: foreign body granulomas with crystals as nidus, in musculo- tendinous unit – olecranon bursa, Achilles tendon, hands, knees, etc.
78
Source Undetermined
Source Undetermined
79. Diagnosis •Rule out cellulitis, septic arthritis particularly if knee joint •All may have fever, leukocytosis, elevated ESR •Uric acid level not helpful •X-rays: soft-tissue swelling (acute) or joint destruction (chronic)
79
80. Uric Acid Levels •Uric acid normal in ~40% •Tophi can form in cool body areas without hyperuricemia •Acute attack pain increased cortisol uric acid diuresis normalized level
80
82. Diagnosis •Definitive diagnosis: birefringent joint fluid crystals with polarizing microscope (a yellow crystal against a red background) and negative joint fluid culture
82
Source Undetermined
83. Acute Therapy – Colchicine •Not diagnostic: works on pseudogout •Contraindication: hematologic, renal, hepatic dysfunction •Extravasation from IV tissue necrosis
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84. Acute Therapy – Colchicine •Inhibits microtubule formation •Most effective in first 24 hours •0.6 mg / hour until pain controlled, max 6 mg or side effects (GI) •Average toxic dose: 6.7 mg •Toxicity precedes improvement in more than 50%
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85. Acute Therapy – Other •NSAIDs effective, indomethacin most common (75 to 200 mg/day) –Contraindicated in PUD, GI bleed •If resistant: prednisone taper –40 mg/day first 3 to 5 days •Adrenocorticotrophic hormone –ACTH 40 IU to 80 IU IM
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86. Pseudogout •Calcium pyrophosphate dihydrate (CPPD) crystal-deposition disease •Knee: most common joint •Polyarticular possible •Pain less severe, patients older •Risk: hypothyroid, Wilson’s disease, hyperparathyroid, hemochromatosis, etc.
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87. Diagnosis •Common: elevated ESR, WBC •X-ray may show joint calcification •Joint fluid –Weakly positive birefringent crystals on polarized microscopy –Appear rhomboidal on regular light microscopy •Treatment: same as gout
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89. Osteoarthritis •Degenerative joint disease •Most common form of arthritis •Loss of articular cartilage, reactive changes at joint margins •Synovitis in advanced disease •May have painful bone-to-bone interface
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97. Diagnosis •Blood cultures usually negative •Synovial fluid cultures positive in less than 50% •Gram’s stain positive more often than culture •Cervical, urethral, pharyngeal, rectal cultures positive ~75%
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98. Treatment •Admit to hospital •Ceftriaxone 1 g IM or IV daily, and 24 to 48 hours after improvement •Ciprofloxacin 500 mg twice daily orally for total 7 days of antibiotics •Spectinomycin 2 grams IM every 12 hours if beta-lactam allergic
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99. Viral Arthritis •Most common: rubella, hepatitis B •Also mumps, adenoviruses, Epstein-Barr virus, enteroviruses •Deposition of soluble immune complexes in synovium with resultant inflammation
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100. Rubella Arthritis •Often young women •Rash several days before •Acute, symmetric, usually polyarticular •Resolves within weeks •Recent infection or vaccination •Virus isolated from synovial fluid
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102. Hepatitis B Arthritis •Usually with or after prodrome of fever and lymphadenopathy •Often precedes jaundice •May be sudden and severe •PIP, knee, ankle, MP joints most commonly involved •Salicylates may be helpful
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103. Lyme •Spirochete: Borrelia burgdorferi •Vector: Ixodes dammini on East Coast and Midwest •Arthritis late manifestation •Within 6 months, half of untreated have frank arthritis –Asymmetric –Most common in knees
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104. Presentation •Minimal joint pain, usually afebrile •Severity of initial presentation predictive of subsequent arthritis •Chronic arthritis more common in patients positive for HLA-DR4 •Joint fluid inflammatory with PMN predominance •Diagnosis is clinical
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111. Ankylosing Spondylitis •Uveitis: most common extra- articular manifestation •Peripheral joints involved in ~30% of patients with enthesopathic involvement (plantar fasciitis and Achilles tendinitis) •Goal of therapy: control pain, decrease inflammation
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112. Reactive Arthritis •AKA arthritis urethritica, venereal arthritis, polyarteritis enterica •Described by German military physician Hans Reiter in 1916 •“Reiter's syndrome” being phased out, partly due to Reiter's typhoid experiments in Nazi concentration camps
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113. Reactive Arthritis •Occurs in genetically susceptible host after infection with GU C. trachomatis, or GI shigella, salmonella, yersinia, campylobacter •Disease of men 15 to 35 years old; arthritis develops 2 to 6 weeks after episode of urethritis or dysentery
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117. Reactive Arthritis •Synovial fluid: inflammatory with predominance of PMNs •Antigens in synovial membrane and joint fluid, cultures sterile •Increased ESR, WBC •HLA-B27 antigen in ~80% •Enthesopathic x-rays, particularly at IP joint of great toe
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118. Reactive Arthritis •NSAID two or three times daily •Doxycycline twice daily x 3 months •Intra-articular steroid injections •If persistent: Sulfasalazine •Chronic therapy for erosive, deforming disease –Methotrexate –Azathioprine (Imuran)
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120. What Happened to Reiter’s? •Hans Julius Reiter (1881 – 1969) •German military physician on Western Front in 1st Hungarian Army •1916: described German Lieutenant with non-gonococcal urethritis, arthritis and uveitis
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121. What Happened to Reiter’s? •Not the first, but he got credit •Member of the SS during WWII •Designed typhus inoculation experiments that killed more than 250 prisoners at Buchenwald •Convicted as war criminal
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123. Rheumatism •An older term used to describe any of a number of painful conditions of muscles, tendons, joints, and bones.
•Rheumatism weed: Canadian dogbane
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SB Johnny (Wikipedia)
124. Acute Rheumatic Fever •Believed to result from Group A streptococcus pharyngitis •Exact mechanism unclear •In decline since antibiotics •Probable abnormal humoral response to antigens
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125. Clinical Syndrome •Recurring self-limited episodes of fever associated with polyarthritis, carditis / valvulitis, rash, subcutaneous nodules, or chorea •Occurs 2 to 3 weeks after streptococcal pharyngitis
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126. Diagnosis – Jones Criteria •Two major, or one major and two minor, criteria with evidence recent Group A streptococcal infection •Major manifestations: polyarthritis, carditis, chorea, erythema marginatum, subcutaneous nodules •Migratory arthritis in large joints
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127. Diagnosis – Jones Criteria •Involves heart in ~50% •Pericarditis, congestive heart failure, valvular dysfunction, cardiomegaly •Neurologic: Sydenham’s chorea, weakness, behavioral disturbance •Sparing of sensory functions
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128. Diagnosis – Jones Criteria
Sinus tachycardia
Right atrial enlargement
Left atrial enlargement
Left ventricular strain
RBBB pattern
1st degree AV block
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Source Undetermined
129. Diagnosis – Jones Criteria •Erythema marginatum: well- demarcated, pink nonpruritic rash, usually trunk, sometimes proximal limbs –Central clearing, may last hours
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Source Undetermined
131. Diagnosis – Jones Criteria •Subcutaneous nodules: firm, nontender under skin overlying bony prominences
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Source Undetermined
132. Laboratory Work-Up •Throat culture, ESR, CRP, ASO •Anti-DNase B 95% sensitive •Streptozyme test also documents recent streptococcal infection •Synovial fluid –Inflammatory (average WBC 16K) –Negative culture
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133. Post-Streptococcal •Reactive arthritis: closely related to ARF but distinct clinical entity •Sterile oligoarthritis associated with distant bacterial infection •Carditis rare, arthritis often severe •Treatment: penicillin, erythromycin •Arthritis responds to salicylates
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135. Rheumatoid Arthritis •Usually chronic: >20% acute •Women 2 to 3 x more than men •Immune complexes stimulate PMNs to release enzymes •Synovial cells proliferate, produce more inflammatory substances
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142. Felty’s Syndrome •Rheumatoid arthritis + splenomegaly + leukopenia •Frequent pneumonia and leg ulcers •1% of RA patients
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Source Undetermined
143. Transverse Ligament Rupture •C1 on C2 subluxation in 70% –Frank dislocation in 25% –Cord compression in 11% •With myelopathy: –5 years survival 80% –10 year survival 28% •Anterior instability more common than posterior instability
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148. Pearls •The number and distribution of joints involved helps pinpoint the most likely cause of arthritis. •Monarthritis is septic arthritis until proven otherwise. •Negative Gram’s stain of synovial fluid does not rule out bacterial arthritis.
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149. Pearls •The most definitive test for evaluating an inflamed joint for the possibility of bacterial infection is examination of synovial fluid. •Delays in the diagnosis and treatment of septic arthritis worsen outcomes.
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