This document discusses neonatal thrombocytopenia, defined as a platelet count below 150,000/cu.mm in newborns. It can be mild, moderate, or severe. Incidence is 1-5% in healthy newborns and higher in preterm/sick infants. Causes include placental insufficiency, infection, maternal conditions, and genetic disorders. Thrombocytopenia is classified as early onset (<72 hours) or late onset (>72 hours) based on time of presentation. Evaluation involves blood tests and smears to identify the cause and guide management, which may include platelet transfusions for severe cases.