The document outlines Merrill's First Principles of Instruction, which propose that effective instruction (1) engages learners in solving real-world problems, (2) activates existing knowledge as a foundation, (3) demonstrates new knowledge to the learner, (4) applies the new knowledge, and (5) integrates the knowledge into the learner's experience. The document also discusses ensuring learners have opportunities to apply their new skills and knowledge and integrating technology as a tool for learning rather than an end in itself.